{"id":"https://openalex.org/W4248515372","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","title":"In situ analysis of transforming growth factors-\u03b2(TGF-\u03b21, TGG-\u03b22, TGF-\u03b23) and TGF-\u03b2 type II receptor expression in basal cell carcinomas","display_name":"In situ analysis of transforming growth factors-\u03b2(TGF-\u03b21, TGG-\u03b22, TGF-\u03b23) and TGF-\u03b2 type II receptor expression in basal cell carcinomas","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W4248515372","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","mag":"2007169157","pmid":"https://pubmed.ncbi.nlm.nih.gov/8763422"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.1996.tb07940.x","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070303328","display_name":"Pirmin Schmid","orcid":"https://orcid.org/0000-0002-1171-7643","observed_orcids":["https://orcid.org/0000-0002-1171-7643"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P. SCHMID","raw_affiliation_strings":["Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047402726","display_name":"Peter H Itin","orcid":"https://orcid.org/0000-0002-7522-002X","observed_orcids":["https://orcid.org/0000-0002-7522-002X"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P. ITIN","raw_affiliation_strings":["Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114043502","display_name":"Th. Rufli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"TH. RUFLI","raw_affiliation_strings":["Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology. University Basel. Petersgraben 4. CH\u20104031 Basel. Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1850255"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":0.6367,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.6549623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"134","issue":"6","first_page":"1044","last_page":"1051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":1.0},{"id":"https://openalex.org/keywords/tgfbeta3","display_name":"TGF-beta3","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stromal-fibrosis","display_name":"stromal fibrosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hair-follicle-epithelium","display_name":"hair follicle epithelium","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.8312546014785767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5277631282806396},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.5061902403831482},{"id":"https://openalex.org/C171020997","wikidata":"https://www.wikidata.org/wiki/Q14911585","display_name":"TGF beta receptor 2","level":5,"score":0.47521740198135376},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46866998076438904},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4176562428474426},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.41693738102912903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38090288639068604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36520129442214966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3286590576171875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.284049928188324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2696905732154846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26064246892929077},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.22656431794166565},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2133.1996.tb07940.x","doi":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1996.tb07940.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"doi:10.1046/j.1365-2133.1996.d01-899.x","doi":"https://doi.org/10.1046/j.1365-2133.1996.d01-899.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2133.1996.d01-899.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:8763422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8763422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"},{"id":"mag:2007169157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8763422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W233491719","https://openalex.org/W1494055834","https://openalex.org/W1539607590","https://openalex.org/W1774709490","https://openalex.org/W1906211198","https://openalex.org/W1967087287","https://openalex.org/W1977439384","https://openalex.org/W1980189675","https://openalex.org/W1986441819","https://openalex.org/W1989897445","https://openalex.org/W2003918448","https://openalex.org/W2025480761","https://openalex.org/W2044068003","https://openalex.org/W2051877942","https://openalex.org/W2081671429","https://openalex.org/W2085419002","https://openalex.org/W2087272945","https://openalex.org/W2087342203","https://openalex.org/W2091391039","https://openalex.org/W2096280264","https://openalex.org/W2098643301","https://openalex.org/W2110384461","https://openalex.org/W2128077493","https://openalex.org/W2136819827","https://openalex.org/W2151825969","https://openalex.org/W2153650716","https://openalex.org/W2158376848","https://openalex.org/W2283610042","https://openalex.org/W2335187016"],"related_works":["https://openalex.org/W2007169157","https://openalex.org/W1970569364","https://openalex.org/W2081671429","https://openalex.org/W6884628698","https://openalex.org/W2418431523","https://openalex.org/W2394226468","https://openalex.org/W3023703024","https://openalex.org/W2368913224","https://openalex.org/W2027167730","https://openalex.org/W2059492449"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,51,80,271],"factor-beta":[2],"(TGF-beta)":[3],"consists":[4],"of":[5,10,23,28,37,49,60,78,102,118,139,145,155,176,191,259],"a":[6,20,35,55],"highly":[7],"homologous":[8],"family":[9],"multifunctional":[11],"peptides":[12],"which":[13,195,248],"are":[14],"differentially":[15],"expressed":[16],"and":[17,44,47,70,88,110,125,163,170,186,212,232],"function":[18],"in":[19,34,57,73,106,111,183,199,208,213,228,274],"wide":[21],"range":[22],"target":[24],"cells.":[25],"Aberrant":[26],"expressions":[27],"TGF-beta":[29,50,84,86,89,103,123,146,149,160,177,192,243,260],"s":[30],"have":[31,68],"been":[32],"implicated":[33],"number":[36],"disease":[38],"processes,":[39],"particularly":[40],"those":[41],"involving":[42],"fibrotic":[43,246],"inflammatory":[45],"lesions,":[46],"loss":[48],"inhibition":[52],"may":[53,266],"play":[54],"part":[56],"the":[58,64,100],"progression":[59,253],"certain":[61],"neoplasms.":[62],"In":[63,216],"present":[65],"study,":[66],"we":[67,238],"analysed":[69],"compared,":[71],"by":[72,98,263],"situ":[74],"hybridization,":[75],"mRNA":[76,130,162,179,223],"expression":[77,131,165,175,224,262],"transforming":[79],"factors-beta":[81],"(TGF-beta":[82],"1,":[83],"2,":[85],"3)":[87],"type":[90],"II":[91,129,222],"receptor":[92],"(T":[93],"beta":[94,127,220],"R":[95,128,221],"II),":[96],"and,":[97],"immunohistochemistry,":[99],"distribution":[101],"3":[104,150,161,261],"protein":[105,164],"normal":[107,135,167,187,209,229],"human":[108],"skin":[109,188,230],"basal":[112],"cell":[113],"carcinoma":[114],"(BCC).":[115],"The":[116],"stroma":[117],"most":[119],"BCCs":[120,140,157],"revealed":[121,158],"enhanced":[122],"1":[124,178],"T":[126,219],"when":[132],"compared":[133],"with":[134],"dermis.":[136],"A":[137],"minority":[138],"also":[141],"showed":[142],"stromal":[143,242],"overexpression":[144],"2":[147,193],"and/or":[148,252],"mRNA.":[151],"However,":[152],"tumour":[153,184,214,233,250,264],"tissues":[154,185],"all":[156],"weaker":[159],"than":[166],"interfollicular":[168,210],"epidermis":[169,211],"hair":[171,201],"follicle":[172,202],"epithelia,":[173,203],"whereas":[174,257],"was":[180,196,204,225],"comparably":[181],"weak":[182],"epithelia.":[189],"Expression":[190],"mRNA,":[194],"clearly":[197],"detectable":[198,207],"distinct":[200],"only":[205],"barely":[206],"tissues.":[215,234],"contrast,":[217],"abundant":[218],"observed":[226],"both":[227],"epithelia":[231],"From":[235],"these":[236],"findings,":[237],"suggest":[239],"that":[240],"increased":[241],"activity":[244],"induces":[245],"alterations":[247],"promote":[249],"survival":[251],"via":[254],"paracrine":[255],"mechanisms,":[256],"lack":[258],"cells":[265],"contribute":[267],"to":[268],"an":[269],"autocrine":[270],"control":[272],"defect":[273],"BCCs.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
