{"id":"https://openalex.org/W4248501801","doi":"https://doi.org/10.22541/au.160029879.92716195","title":"ANTIFUNGAL PROPHYLAXIS WITH POSACONAZOLE IN IMMUNOCOMPROMISED CHILDREN UNDER 13 YEARS OF AGE IN A REFERENCE HOSPITAL IN LIMA, PERU","display_name":"ANTIFUNGAL PROPHYLAXIS WITH POSACONAZOLE IN IMMUNOCOMPROMISED CHILDREN UNDER 13 YEARS OF AGE IN A REFERENCE HOSPITAL IN LIMA, PERU","publication_year":2020,"publication_date":"2020-09-16","ids":{"openalex":"https://openalex.org/W4248501801","doi":"https://doi.org/10.22541/au.160029879.92716195"},"language":"en","primary_location":{"id":"doi:10.22541/au.160029879.92716195","doi":"https://doi.org/10.22541/au.160029879.92716195","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.160029879.92716195","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.160029879.92716195","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.authorea.com/doi/pdf/10.22541/au.160029879.92716195","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067546989","display_name":"Julio Maquera-Afaray","orcid":"https://orcid.org/0000-0002-3698-8343","observed_orcids":["https://orcid.org/0000-0002-3698-8343"]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Julio Maquera-Afaray","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052049623","display_name":"Medalit Luna-V\u00edlchez","orcid":"https://orcid.org/0000-0003-3351-7877","observed_orcids":["https://orcid.org/0000-0003-3351-7877"]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Medalit Luna-Vilchez","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059218905","display_name":"Blanca Salazar-Mesones","orcid":"https://orcid.org/0000-0001-9667-5376","observed_orcids":["https://orcid.org/0000-0001-9667-5376"]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Blanca Salazar-Mesones","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039496599","display_name":"Diana Portillo Alvarez","orcid":"https://orcid.org/0000-0002-7359-153X","observed_orcids":["https://orcid.org/0000-0002-7359-153X"]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Diana Portillo-Alvarez","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019567408","display_name":"Luis Uribe Ramirez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Luis Uribe- Ramirez","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011712195","display_name":"Graciela Taipe-Sedano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Graciela Taipe-Sedano","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058441430","display_name":"Carlos Santill n Salas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Carlos Santill\u00e1n-Salas","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073502511","display_name":"Jos L pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153073","display_name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja","ror":"https://ror.org/03yhwzd24","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4387153073"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 L\u00f3pez","raw_affiliation_strings":["Instituto Nacional de Salud del Ni\u00f1o San Borja"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud del Ni\u00f1o San Borja","institution_ids":["https://openalex.org/I4387153073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387153073"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":1.0},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunocompromised-children","display_name":"immunocompromised children","score":0.9049999713897705},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/breakthrough-fungal-infection","display_name":"breakthrough fungal infection","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4970000088214874},{"id":"https://openalex.org/keywords/transaminase-elevation","display_name":"transaminase elevation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2778566413","wikidata":"https://www.wikidata.org/wiki/Q906453","display_name":"Posaconazole","level":4,"score":0.8466165065765381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8376822471618652},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.5940373539924622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5695045590400696},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5176647305488586},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.503152072429657},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4795093834400177},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.47752606868743896},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41334301233291626},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.4111383557319641},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3503914475440979},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34653201699256897},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.3309442400932312},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.2815396785736084},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.08966413140296936},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22541/au.160029879.92716195","doi":"https://doi.org/10.22541/au.160029879.92716195","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.160029879.92716195","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.160029879.92716195","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.22541/au.160029879.92716195","doi":"https://doi.org/10.22541/au.160029879.92716195","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.160029879.92716195","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.160029879.92716195","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4248501801.pdf","grobid_xml":"https://content.openalex.org/works/W4248501801.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2015614371","https://openalex.org/W2023776191","https://openalex.org/W2040551518","https://openalex.org/W2116440163","https://openalex.org/W2127167028","https://openalex.org/W2166734004","https://openalex.org/W2464902886","https://openalex.org/W2528067515","https://openalex.org/W2560949970","https://openalex.org/W2591985894","https://openalex.org/W2794195505","https://openalex.org/W2800655239","https://openalex.org/W2809054925","https://openalex.org/W2922800780","https://openalex.org/W2946270661","https://openalex.org/W2994704762"],"related_works":["https://openalex.org/W4200521893","https://openalex.org/W2996006697","https://openalex.org/W2015614371","https://openalex.org/W3126283489","https://openalex.org/W2980044775","https://openalex.org/W2591985894","https://openalex.org/W2315987115","https://openalex.org/W2587934323","https://openalex.org/W3141641365","https://openalex.org/W4408128639"],"abstract_inverted_index":{"Background:":[0],"Prophylaxis":[1],"with":[2,63,104],"posaconazole":[3,43,150],"(PP)":[4],"has":[5],"shown":[6],"to":[7,38,91],"be":[8],"effective":[9],"in":[10,17,28,47,101,189,221],"the":[11,35,40,52,78,157],"prevention":[12],"of":[13,23,34,42,55,61,108,117,149,160,200,226],"invasive":[14],"fungal":[15,202,209],"infections":[16],"immunocompromised":[18,56],"adult":[19],"patients.":[20],"However,":[21],"evaluation":[22],"its":[24],"effectiveness":[25],"and":[26,66,141,156,177,183,193,214],"safety":[27],"children":[29,222],"is":[30],"limited.":[31],"The":[32,121,146],"aim":[33],"study":[36],"was":[37,151,162],"describe":[39],"use":[41],"as":[44],"antifungal":[45,75,96],"prophylaxis":[46,97],"children.":[48],"Methods:":[49],"We":[50],"reviewed":[51],"medical":[53,124],"records":[54],"patients":[57,103,191],"under":[58,223],"13":[59,224],"years":[60,110,225],"age":[62,107],"hematological":[64],"diseases":[65],"post":[67],"hematopoietic":[68],"stem":[69],"cell":[70],"transplantation":[71],"(HSCT)":[72],"who":[73],"received":[74],"PP":[76,161,220],"at":[77],"Instituto":[79],"Nacional":[80],"de":[81],"Salud":[82],"del":[83],"Ni\u00f1o":[84],"San":[85],"Borja":[86],"(Per\u00fa)":[87],"from":[88],"January":[89],"2014":[90],"December":[92],"2018.":[93],"Results:":[94],"Fifty-six":[95],"events":[98],"were":[99,119,126,187,204,217],"identified":[100,205],"47":[102],"a":[105],"median":[106,147,158],"7.5":[109],"(interquartile":[111],"range":[112],"[IQR]":[113],"4-10),":[114],"51.6%":[115],"(n=24)":[116],"whom":[118],"female.":[120],"main":[122],"underlying":[123],"conditions":[125],"aplastic":[127],"anemia":[128],"(n=19,":[129],"33.9%),":[130],"acute":[131,136],"lymphoblastic":[132],"leukemia":[133,138],"(n=18,":[134],"32.1%),":[135],"myeloid":[137],"(n=14,":[139],"25.0%),":[140],"34.1%":[142],"had":[143],"undergone":[144],"HSCT.":[145],"dose":[148],"13.62":[152],"mg/kg/day":[153],"(IQR:":[154,165],"12.0-16.8),":[155],"duration":[159],"24":[163],"days":[164],"16-82).":[166],"Gastrointestinal":[167],"symptoms":[168,216],"included":[169],"abdominal":[170],"pain":[171],"(17.9%),":[172],"nausea":[173],"(16.1%),":[174],"diarrhea":[175],"(7.1%)":[176],"vomiting":[178],"(3.6%).":[179],"Elevated":[180],"alanine":[181],"aminotransferase":[182,185],"aspartate":[184],"levels":[186,213],"observed":[188,218],"9/35":[190],"(25.7%)":[192],"10/51":[194],"(19.6%)":[195],"patients,":[196],"respectively.":[197],"Five":[198],"cases":[199],"breakthrough":[201],"infection":[203],"(8.9%).":[206],"Conclusions:":[207],"Breakthrough":[208],"infection,":[210],"increased":[211],"transaminase":[212],"gastrointestinal":[215],"during":[219],"age.":[227]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-12T00:00:00"}
