{"id":"https://openalex.org/W4248237995","doi":"https://doi.org/10.1002/ange.201504156","title":"Synthesis of Fluorophores that Target Small Molecules to the Endoplasmic Reticulum of Living Mammalian Cells","display_name":"Synthesis of Fluorophores that Target Small Molecules to the Endoplasmic Reticulum of Living Mammalian Cells","publication_year":2015,"publication_date":"2015-06-26","ids":{"openalex":"https://openalex.org/W4248237995","doi":"https://doi.org/10.1002/ange.201504156"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201504156","doi":"https://doi.org/10.1002/ange.201504156","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201504156","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070827147","display_name":"J. Matthew Meinig","orcid":"https://orcid.org/0000-0003-2019-2890","observed_orcids":["https://orcid.org/0000-0003-2019-2890"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Matthew Meinig","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030209217","display_name":"Liqiang Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liqiang Fu","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040465204","display_name":"Blake R. Peterson","orcid":"https://orcid.org/0000-0001-8251-3579","observed_orcids":["https://orcid.org/0000-0001-8251-3579"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Blake R. Peterson","raw_affiliation_strings":["Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 (USA)","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040465204"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.26181818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"127","issue":"33","first_page":"9832","last_page":"9835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-targeting","display_name":"endoplasmic reticulum targeting","score":0.9580000042915344},{"id":"https://openalex.org/keywords/small-molecule-delivery","display_name":"small molecule delivery","score":0.6430000066757202},{"id":"https://openalex.org/keywords/protein-processing","display_name":"protein processing","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8857423067092896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6476547718048096},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5978649258613586},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5385947823524475},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5042737722396851},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47142690420150757},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4557863771915436},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.4267526865005493},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.42401692271232605},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.41860708594322205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40098321437835693},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23349550366401672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21337684988975525},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06553849577903748},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201504156","doi":"https://doi.org/10.1002/ange.201504156","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201504156","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1570610869","https://openalex.org/W1971941771","https://openalex.org/W1976161806","https://openalex.org/W1977222014","https://openalex.org/W1977502249","https://openalex.org/W1978567096","https://openalex.org/W1979659513","https://openalex.org/W1985286323","https://openalex.org/W1987467454","https://openalex.org/W1988186235","https://openalex.org/W1991989590","https://openalex.org/W1994880547","https://openalex.org/W2001399725","https://openalex.org/W2002005764","https://openalex.org/W2003444377","https://openalex.org/W2012265138","https://openalex.org/W2022085272","https://openalex.org/W2022558976","https://openalex.org/W2034268083","https://openalex.org/W2041922485","https://openalex.org/W2049512057","https://openalex.org/W2054827827","https://openalex.org/W2061843432","https://openalex.org/W2063987302","https://openalex.org/W2068306128","https://openalex.org/W2070349270","https://openalex.org/W2075779920","https://openalex.org/W2080776472","https://openalex.org/W2093815103","https://openalex.org/W2114989261","https://openalex.org/W2115660554","https://openalex.org/W2125542684","https://openalex.org/W2125872855","https://openalex.org/W2126998570","https://openalex.org/W2129574945","https://openalex.org/W2136109073","https://openalex.org/W2151020295","https://openalex.org/W2154127938","https://openalex.org/W2154419144","https://openalex.org/W2162679859","https://openalex.org/W2162969910"],"related_works":["https://openalex.org/W2556635607","https://openalex.org/W4408533150","https://openalex.org/W2346645427","https://openalex.org/W4282938046","https://openalex.org/W4391330311","https://openalex.org/W2093815103","https://openalex.org/W4206933899","https://openalex.org/W2749631421","https://openalex.org/W3005403695","https://openalex.org/W4405092141"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"endoplasmic":[2],"reticulum":[3],"(ER)":[4],"plays":[5],"critical":[6],"roles":[7],"in":[8,51,101],"the":[9,29,52,72,95,98,105,116,127],"processing":[10,114],"of":[11,28,41,54,90,129],"secreted":[12],"and":[13,44,110,136],"transmembrane":[14],"proteins.":[15],"To":[16,65],"deliver":[17],"small":[18,130],"molecules":[19,131],"to":[20,48,80,84,94,104],"this":[21,91],"organelle,":[22],"we":[23,74],"synthesized":[24],"fluorinated":[25,77],"hydrophobic":[26,78,120],"analogues":[27],"fluorophore":[30],"rhodol.":[31],"These":[32],"cell\u2010permeable":[33],"fluorophores":[34,124],"are":[35,122],"exceptionally":[36],"bright,":[37],"with":[38],"quantum":[39],"yields":[40],"around":[42],"0.8,":[43],"they":[45],"were":[46],"found":[47],"specifically":[49,111],"accumulate":[50],"ER":[53,96],"living":[55],"HeLa":[56],"cells,":[57],"as":[58],"imaged":[59],"by":[60,71,97,115],"confocal":[61],"laser":[62],"scanning":[63],"microscopy.":[64],"target":[66],"a":[67,76],"biological":[68],"pathway":[69],"controlled":[70],"ER,":[73],"linked":[75],"rhodol":[79,99],"5\u2010nitrofuran\u20102\u2010acrylaldehyde.":[81],"In":[82],"contrast":[83],"an":[85],"untargeted":[86],"nitrofuran":[87,93],"warhead,":[88],"delivery":[89,128],"electrophilic":[92],"resulted":[100],"cytotoxicity":[102],"comparable":[103],"ER\u2010targeted":[106],"cytotoxin":[107],"eeyarestatin":[108],"I,":[109],"inhibited":[112],"protein":[113],"ubiquitin\u2013proteasome":[117],"system.":[118],"Fluorinated":[119],"rhodols":[121],"outstanding":[123],"that":[125],"enable":[126],"for":[132],"targeting":[133],"ER\u2010associated":[134],"proteins":[135],"pathways.":[137]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-05-12T00:00:00"}
