{"id":"https://openalex.org/W4248146405","doi":"https://doi.org/10.1158/1538-7445.am2019-827","title":"Abstract 827: Estimating breast tissue-specific epigenetic age using next-generation methylation sequencing data","display_name":"Abstract 827: Estimating breast tissue-specific epigenetic age using next-generation methylation sequencing data","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4248146405","doi":"https://doi.org/10.1158/1538-7445.am2019-827"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-827","doi":"https://doi.org/10.1158/1538-7445.am2019-827","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-827","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040543521","display_name":"J. Castle","orcid":"https://orcid.org/0000-0002-2177-617X","observed_orcids":["https://orcid.org/0000-0002-2177-617X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Castle","raw_affiliation_strings":["1University of Kentucky, Lexington, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kentucky, Lexington, KY;","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101021783","display_name":"Nan Lin","orcid":"https://orcid.org/0000-0001-7731-0072","observed_orcids":["https://orcid.org/0000-0001-7731-0072"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Lin","raw_affiliation_strings":["1University of Kentucky, Lexington, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kentucky, Lexington, KY;","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012607011","display_name":"Jingpeng Liu","orcid":"https://orcid.org/0000-0002-5452-9052","observed_orcids":["https://orcid.org/0000-0002-5452-9052"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingpeng Liu","raw_affiliation_strings":["1University of Kentucky, Lexington, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kentucky, Lexington, KY;","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995","observed_orcids":["https://orcid.org/0000-0001-8984-4995"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Wang","raw_affiliation_strings":["1University of Kentucky, Lexington, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kentucky, Lexington, KY;","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337355","display_name":"Yunlong Liu","orcid":"https://orcid.org/0000-0002-2699-626X","observed_orcids":["https://orcid.org/0000-0002-2699-626X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunlong Liu","raw_affiliation_strings":["2Indiana University, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Indiana University, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023120961","display_name":"Chunyan He","orcid":"https://orcid.org/0000-0001-9443-4368","observed_orcids":["https://orcid.org/0000-0001-9443-4368","https://orcid.org/0000-0003-0231-3599"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunyan He","raw_affiliation_strings":["1University of Kentucky, Lexington, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kentucky, Lexington, KY;","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"827","last_page":"827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-age","display_name":"epigenetic age","score":0.8410000205039978},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.8550000190734863},{"id":"https://openalex.org/keywords/epigenetic-age-acceleration","display_name":"epigenetic age acceleration","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/horvath-clock","display_name":"Horvath clock","score":0.8399999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-tissue","display_name":"tumor tissue","score":0.42899999022483826},{"id":"https://openalex.org/keywords/adjacent-normal-tissue","display_name":"adjacent normal tissue","score":0.8100000023841858},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8783168196678162},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8004969954490662},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.686520516872406},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6425200700759888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6192538738250732},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5660988688468933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41484954953193665},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37612372636795044},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3267802298069},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28107786178588867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17728307843208313},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09863537549972534}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-827","doi":"https://doi.org/10.1158/1538-7445.am2019-827","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-827","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3012152443","https://openalex.org/W4409114861","https://openalex.org/W2642579468","https://openalex.org/W2889199419","https://openalex.org/W4220863873","https://openalex.org/W2598804691","https://openalex.org/W3014028661","https://openalex.org/W2912485442","https://openalex.org/W4322775091","https://openalex.org/W6920907875"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1,21,31],"age":[2,22,27,32,54,130,199,239,255,261,348,390],"captures":[3],"both":[4],"genetic":[5],"and":[6,14,118,124,166,207,227,240,245,282,300,307,311,315,333,360],"environmental":[7],"influences":[8],"across":[9],"time":[10],"on":[11,66,74,200],"cellular":[12],"functions":[13],"is":[15,33,64,342,354],"an":[16,190],"indicator":[17],"of":[18,48,70,83,153,174,212,319,356,369,399],"biological":[19],"aging.":[20],"may":[23],"deviate":[24],"from":[25],"chronological":[26,125,198,260],"substantially":[28],"in":[29,133,159,203,242,350],"individuals.":[30],"also":[34],"tissue-specific.":[35],"Emerging":[36],"evidence":[37],"suggests":[38],"that":[39,91,251],"female":[40],"breast":[41,109,135,169,205,218,236,247,252,269,277,292,302,352,357,362,387],"tissue":[42,136,170,206,219,270,278,353],"ages":[43],"faster":[44],"than":[45],"other":[46],"parts":[47],"the":[49,57,67,75,120,185,329,367,400],"body":[50],"according":[51],"to":[52,97,107,148,196,217,325,336,344],"epigenetic":[53,100,111,123,129,238,254,347,389],"estimation":[55],"using":[56,113,328,391],"\"Horvath":[58],"Clock\"":[59],"model.":[60],"The":[61,80,138],"Horvath":[62,186,330],"method":[63,89,106],"based":[65],"DNA":[68,93,150],"methylation":[69,94,115,151,393],"353":[71],"CpG":[72,157,178,201],"loci":[73],"outdated":[76],"Illumina":[77,139],"microarray":[78],"platforms.":[79],"increasing":[81],"availability":[82],"next-generation":[84,114,392],"sequencing":[85,95,116,394],"data":[86,96,117,232,395],"calls":[87],"for":[88,403],"development":[90],"uses":[92],"estimate":[98,108],"tissue-specific":[99,110,237,253,388],"age.":[101],"We":[102,234,249],"developed":[103],"a":[104,209,272,280,305],"new":[105,210,321],"aging":[112],"assessed":[119],"difference":[121],"between":[122],"ages,":[126],"known":[127],"as":[128],"acceleration":[131,349],"(EAA),":[132],"different":[134],"types.":[137],"TruSeq":[140],"Methyl":[141],"Capture":[142],"EPIC":[143],"Sequencing":[144],"technology":[145],"was":[146,256],"used":[147,189],"obtain":[149],"profiles":[152],"approximately":[154,175],"3.3":[155],"million":[156,177],"sites":[158,179,202],"111":[160],"tumor,":[161,243],"48":[162],"matched":[163],"adjacent":[164,267],"normal,":[165],"462":[167],"normal":[168,204,246,265,268,351],"samples.":[171],"A":[172],"total":[173],"1.4":[176],"remained":[180],"after":[181],"quality":[182],"control.":[183],"Following":[184],"approach,":[187],"we":[188],"elastic":[191],"net":[192],"penalized":[193],"regression":[194],"model":[195,322,332],"regress":[197],"defined":[208],"set":[211],"247":[213],"clock":[214],"CpGs":[215],"specific":[216],"with":[220,259],"randomly":[221],"divided":[222],"training":[223],"(n":[224,229],"=":[225,230,286],"370)":[226],"testing":[228],"92)":[231],"sets.":[233],"estimated":[235],"EAA":[241,284,309],"adjacent,":[244],"tissue.":[248],"found":[250,335],"positively":[257],"correlated":[258],"(r=0.87;":[262],"P<2.2X10-16).":[263],"Neither":[264],"nor":[266],"showed":[271,294],"significant":[273,281,296,306],"EAA.":[274],"However,":[275],"tumor":[276],"had":[279,304],"increased":[283,308],"(median":[285],"8.0":[287],"years;":[288,313],"P=6.9X10-9).":[289],"While":[290],"triple-negative":[291],"tumors":[293,303],"no":[295],"EAA,":[297],"hormone":[298],"receptive-positive":[299],"Her2-positive":[301],"(median=9.5":[310],"13.1":[312],"P=1X10-5":[314],"0.02,":[316],"respectively).":[317],"Results":[318],"this":[320],"were":[323,334],"compared":[324],"similar":[326],"results":[327],"Clock":[331],"be":[337],"qualitatively":[338],"consistent.":[339],"Further":[340],"research":[341],"needed":[343],"determine":[345],"whether":[346],"predictive":[355],"cancer":[358,363],"risk":[359,364],"how":[361],"factors":[365],"influence":[366],"rate":[368],"acceleration.":[370],"Citation":[371],"Format:":[372],"James":[373],"R.":[374],"Castle,":[375],"Nan":[376],"Lin,":[377],"Jingpeng":[378],"Liu,":[379,383],"Chi":[380],"Wang,":[381],"Yunlong":[382],"Chunyan":[384],"He.":[385],"Estimating":[386],"[abstract].":[396],"In:":[397],"Proceedings":[398],"American":[401],"Association":[402],"Cancer":[404,418],"Research":[405],"Annual":[406],"Meeting":[407],"2019;":[408],"2019":[409],"Mar":[410],"29-Apr":[411],"3;":[412],"Atlanta,":[413],"GA.":[414],"Philadelphia":[415],"(PA):":[416],"AACR;":[417],"Res":[419],"2019;79(13":[420],"Suppl):Abstract":[421],"nr":[422],"827.":[423]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-05-12T00:00:00"}