{"id":"https://openalex.org/W4248080927","doi":"https://doi.org/10.1089/hgt.2008.001","title":"TRAIL recombinant adenovirus triggered robust apoptosis in multidrug resistant HL-60/Vinc cells preferentially through the death receptor DR5","display_name":"TRAIL recombinant adenovirus triggered robust apoptosis in multidrug resistant HL-60/Vinc cells preferentially through the death receptor DR5","publication_year":2008,"publication_date":"2008-05-13","ids":{"openalex":"https://openalex.org/W4248080927","doi":"https://doi.org/10.1089/hgt.2008.001"},"language":"en","primary_location":{"id":"doi:10.1089/hgt.2008.001","doi":"https://doi.org/10.1089/hgt.2008.001","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgt.2008.001","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107640079","display_name":"Ching Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching Wu","raw_affiliation_strings":["Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202","institution_ids":["https://openalex.org/I4390039234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365848","display_name":"Chinghai H. Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinghai Kao","raw_affiliation_strings":["Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202","institution_ids":["https://openalex.org/I4390039234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112151353","display_name":"Ahmad R. Safa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmad R. Safa","raw_affiliation_strings":["Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology and Indiana University Simon Cancer Center 1044 W. Walnut Street, R4-119 Indianapolis, IN 46202","institution_ids":["https://openalex.org/I4390039234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112151353"],"corresponding_institution_ids":["https://openalex.org/I4390039234"],"apc_list":null,"apc_paid":null,"fwci":0.1364,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54858484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"0","issue":"ja","first_page":"080513065304552","last_page":"080513065304552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9919999837875366},{"id":"https://openalex.org/keywords/recombinant-adenovirus","display_name":"recombinant adenovirus","score":0.9229999780654907},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dr4","display_name":"DR4","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dcr1","display_name":"DcR1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9769999980926514},{"id":"https://openalex.org/keywords/caspase-10","display_name":"caspase-10","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9599999785423279},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trail-resistance","display_name":"TRAIL resistance","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7099364995956421},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6835166215896606},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5802621245384216},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4755042493343353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4548400938510895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44843924045562744},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44721463322639465},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4464492201805115},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.346868097782135},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.22743216156959534},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19714224338531494},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.13105541467666626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12625554203987122}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1089/hgt.2008.001","doi":"https://doi.org/10.1089/hgt.2008.001","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgt.2008.001","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1799613264","display_name":null,"funder_award_id":"CA 90878","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6545621466","display_name":null,"funder_award_id":"CA101743","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W85529956","https://openalex.org/W161377905","https://openalex.org/W1971831772","https://openalex.org/W1979883538","https://openalex.org/W2016836935","https://openalex.org/W2020329223","https://openalex.org/W2051758487","https://openalex.org/W2062247572","https://openalex.org/W2106284224"],"related_works":["https://openalex.org/W1987639379","https://openalex.org/W2979974523","https://openalex.org/W2016038349","https://openalex.org/W2779290810","https://openalex.org/W2151804943","https://openalex.org/W2493253332","https://openalex.org/W4206026231","https://openalex.org/W2407866602","https://openalex.org/W2014094604","https://openalex.org/W2393539718"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor-related":[2],"apoptosis-inducing":[3,16],"ligand":[4],"(TRAIL)":[5],"is":[6],"a":[7,37,45],"promising":[8],"cancer":[9,24],"therapeutic":[10,171],"because":[11],"of":[12,50,59,120,154],"its":[13],"highly":[14],"selective":[15],"action":[17],"on":[18],"neoplastic":[19],"versus":[20],"normal":[21,67],"cells.However,":[22],"some":[23],"cells":[25,53,86,92,177],"express":[26],"resistance":[27],"to":[28,41,125,132,184],"recombinant":[29],"soluble":[30],"TRAIL.To":[31],"overcome":[32],"this":[33],"problem,":[34],"we":[35],"used":[36],"TRAIL":[38],"adenovirus":[39],"(Ad5/35-TRAIL)":[40],"induce":[42,64],"apoptosis":[43,65,73,82,107,113],"in":[44,66,74,83,88,114,147,163],"drug-sensitive":[46],"and":[47,54,95,122,178,186],"multidrug-resistant":[48],"variant":[49],"HL-60":[51,89],"leukemia":[52,77],"determined":[55],"the":[56,91,106,127,133,152],"molecular":[57],"mechanisms":[58],"Ad5/35-TRAIL-induced":[60],"apoptosis.Ad5/35-TRAIL":[61],"did":[62],"not":[63],"human":[68],"lymphocytes,":[69],"but":[70],"caused":[71],"massive":[72],"acute":[75,188],"myelocytic":[76,189],"cells.It":[78],"triggered":[79,108,137],"more":[80],"efficient":[81],"drug-resistant":[84],"HL-60/Vinc":[85,148],"than":[87],"cells.Treating":[90],"with":[93],"anti-DR4":[94],"anti-DR5":[96],"neutralizing":[97],"antibodies":[98],"(particularly":[99],"anti-DR5)":[100],"reduced,":[101],"whereas":[102],"anti-DcR1":[103],"antibody":[104],"enhanced,":[105],"by":[109],"Ad5/35-TRAIL.Whereas":[110],"Ad5/35-TRAIL":[111,166],"induced":[112],"both":[115],"cell":[116,128],"lines":[117],"through":[118],"activation":[119],"caspase-3":[121],"caspase-10,":[123],"known":[124],"link":[126],"death":[129],"receptor":[130],"pathway":[131],"mitochondrial":[134,139],"pathway,":[135],"it":[136],"increased":[138,151],"membrane":[140],"potential":[141],"change":[142],"(\u232c":[143],"m":[144],")":[145],"only":[146],"cells.Ad5/35-TRAIL":[149],"also":[150],"production":[153],"reactive":[155],"oxygen":[156],"species,":[157],"which":[158],"play":[159],"an":[160,169],"important":[161],"role":[162],"apoptosis.Therefore,":[164],"using":[165],"may":[167,181],"be":[168],"effective":[170],"strategy":[172],"for":[173],"eliminating":[174],"TRAIL-resistant":[175],"malignant":[176],"these":[179],"studies":[180],"provide":[182],"clues":[183],"treat":[185],"eradicate":[187],"leukemias.":[190]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}
