{"id":"https://openalex.org/W4248060081","doi":"https://doi.org/10.1016/j.jalz.2011.05.2012","title":"O4\u201007\u201001: Amyloid imaging in nondemented oldest\u2010old","display_name":"O4\u201007\u201001: Amyloid imaging in nondemented oldest\u2010old","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W4248060081","doi":"https://doi.org/10.1016/j.jalz.2011.05.2012"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.2012","doi":"https://doi.org/10.1016/j.jalz.2011.05.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.2012","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029440312","display_name":"Chester A. Mathis","orcid":"https://orcid.org/0000-0001-9811-0950","observed_orcids":["https://orcid.org/0000-0001-9811-0950"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester Mathis","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Snitz","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758454","display_name":"Julie C. Price","orcid":"https://orcid.org/0000-0001-7131-4865","observed_orcids":["https://orcid.org/0000-0001-7131-4865"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Price","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036841670","display_name":"William Edward Klunk","orcid":"https://orcid.org/0000-0001-5512-0251","observed_orcids":["https://orcid.org/0000-0001-5512-0251"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Klunk","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088223178","display_name":"Judith A. Saxton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Saxton","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036610114","display_name":"Lisa A. Weissfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Weissfeld","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040792993","display_name":"Bedda L. Rosario","orcid":"https://orcid.org/0000-0001-8795-4242","observed_orcids":["https://orcid.org/0000-0001-8795-4242"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bedda Rosario","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087916636","display_name":"Lewis H. Kuller","orcid":"https://orcid.org/0000-0002-7148-8416","observed_orcids":["https://orcid.org/0000-0002-7148-8416"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis Kuller","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Lopez","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, Penn., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, Penn., United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084618289","display_name":"Steven Trent DeKosky","orcid":"https://orcid.org/0000-0003-3743-2758","observed_orcids":["https://orcid.org/0000-0003-3743-2758"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven DeKosky","raw_affiliation_strings":["University of Virginia School of Medicine, Charlottesville, Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia School of Medicine, Charlottesville, Virginia, United States","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50236066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S_Part_20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-imaging","display_name":"amyloid imaging","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pib-pet","display_name":"PiB PET","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.64918452501297},{"id":"https://openalex.org/C2778733324","wikidata":"https://www.wikidata.org/wiki/Q2998088","display_name":"Posterior cingulate","level":3,"score":0.5825193524360657},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5823180079460144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5116065144538879},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5021212100982666},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4509434998035431},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.444854199886322},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3864097595214844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3702816665172577},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.22671660780906677},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1714910864830017},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.11276131868362427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.2012","doi":"https://doi.org/10.1016/j.jalz.2011.05.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.2012","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066355131","https://openalex.org/W2075348467","https://openalex.org/W1992640748","https://openalex.org/W1908308221","https://openalex.org/W2004344916","https://openalex.org/W2615588029","https://openalex.org/W2275549962","https://openalex.org/W2163247286","https://openalex.org/W4243558269","https://openalex.org/W4232092939"],"abstract_inverted_index":{"PiB":[0,40,77,98,121],"PET":[1,41,122],"was":[2,43,103,156,163,182,209,223,261],"used":[3],"to":[4,115,290,309],"assess":[5],"amyloid":[6,338],"load":[7],"in":[8,45,207,213,217,225,229,266,274,280,286,292,300,305,311,346,352,359,366,371],"a":[9,166,319],"cohort":[10,222],"of":[11,17,25,129,238,243,251,264,272,278,298,322,333,337,364,369],"190":[12],"older":[13],"individuals":[14],"(82-95":[15],"years":[16],"age":[18,154,373],"(YOA))":[19],"from":[20,284,303],"the":[21,73,106,175,202,218,267,347,353,362],"Pittsburgh":[22,119],"Ginkgo":[23],"Evaluation":[24],"Memory":[26],"Study":[27],"(PGEMS)":[28],"who":[29,192],"were":[30,79,193,246,254],"cognitively":[31],"normal":[32,354],"(NL)":[33],"or":[34,161,199],"had":[35,329],"mild":[36],"cognitive":[37],"impairment":[38],"(MCI).":[39],"imaging":[42],"performed":[44],"152":[46],"PGEMS":[47,60,186,232,252],"NL":[48,131,208,226,240,268,281],"(MMSE":[49,62,132,144],"=":[50,63,126,133,145],"28":[51,146],"\u00b1":[52,55,65,68,135,138,147,150],"2;":[53,136,148],"85":[54],"3":[56,69],"YOA)":[57,140],"and":[58,76,87,95,141,211,227,241,269],"38":[59],"MCI":[61,143,245,301],"25":[64],"3;":[66],"86":[67],"YOA).":[70],"MRI":[71,82],"defined":[72],"regions-of-interest":[74],"(ROIs),":[75],"images":[78],"sampled":[80],"using":[81,105,165],"template":[83],"ROIs":[84],"including":[85],"anterior":[86],"posterior":[88],"cingulate,":[89],"parietal,":[90],"frontal,":[91],"lateral":[92],"temporal":[93],"cortices":[94],"cerebellum":[96],"(CER).":[97],"retention":[99],"50-70":[100],"min":[101],"post-injection":[102],"measured":[104],"standardized":[107],"uptake":[108],"value":[109],"ratio":[110],"for":[111,184,258],"each":[112],"ROI":[113],"relative":[114],"CER.":[116],"A":[117],"comparative":[118],"(PITT)":[120],"data":[123,172,357],"set":[124],"(n":[125],"123)":[127],"consisted":[128],"77":[130],"29":[134],"71":[137],"6":[139],"46":[142],"68":[149],"7":[151],"YOA),":[152],"whose":[153],"range":[155],"54-79.":[157],"Amyloid":[158],"status":[159,181],"(PiB+":[160],"PIB-)":[162],"determined":[164],"statistical":[167],"outlier":[168],"method":[169],"based":[170],"on":[171],"quartiles":[173],"over":[174],"five":[176],"specified":[177],"cortical":[178],"regions.":[179],"APOE":[180],"available":[183],"158":[185],"subjects":[187,253,282,287,293,306,312],"(126":[188],"NL,":[189],"32":[190],"MCI)":[191],"classified":[194],"as":[195,340],"either":[196],"E4":[197,259],"carrier":[198],"non-carrier.":[200],"Of":[201],"\u201coldest-old\u201d":[203],"PGEMS,":[204],"PiB+":[205,215,324],"prevalence":[206,216,332,363],"51%":[210],"68%":[212],"MCI.":[214,230,275],"(younger)":[219],"PITT":[220],"elderly":[221],"21%":[224],"46%":[228],"In":[231],"cases":[233,328],">":[234,294,313],"90":[235],"YOA,":[236],"67%":[237],"15":[239],"100%":[242,270],"5":[244],"PiB+.":[247],"While":[248],"only":[249],"17%":[250],"APOE4":[255,316],"carriers,":[256],"PiB-positivity":[257,279,299,343],"carriers":[260,317],"84%":[262],"(21":[263],"25)":[265],"(7":[271],"7)":[273],"The":[276,335],"presence":[277,336],"increased":[283,302,344],"\u223c20%":[285],"54-79":[288,307],"YOA":[289,308],"\u223c50%":[291,304],"82":[295,314],"YOA.":[296,315],"Prevalence":[297],"\u223c70%":[310],"comprised":[318],"low":[320],"percentage":[321],"oldest-old":[323],"subjects,":[325],"but":[326],"those":[327],"very":[330],"high":[331],"PiB-positivity.":[334],"pathology":[339],"indexed":[341],"by":[342],"progressively":[345],"oldest-old,":[348],"even":[349],"with":[350,361],"cognition":[351],"range.":[355,374],"These":[356],"are":[358],"agreement":[360],"amyloid-positivity":[365],"autopsy":[367],"studies":[368],"people":[370],"this":[372]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}