{"id":"https://openalex.org/W4247956682","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533","title":"Results from a phase II trial of conformal radiation therapy for pediatric patients with localized low-grade astrocytoma and quantification of radiation-related CNS effects","display_name":"Results from a phase II trial of conformal radiation therapy for pediatric patients with localized low-grade astrocytoma and quantification of radiation-related CNS effects","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W4247956682","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.8533","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006930070","display_name":"Thomas E. Merchant","orcid":"https://orcid.org/0000-0002-0412-6255","observed_orcids":["https://orcid.org/0000-0002-0412-6255"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. E. Merchant","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028974844","display_name":"Erin N. Kiehna","orcid":"https://orcid.org/0000-0002-2289-3917","observed_orcids":["https://orcid.org/0000-0002-2289-3917"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. N. Kiehna","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058866129","display_name":"Raymond K. Mulhern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. K. Mulhern","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042463331","display_name":"Larry E. Kun","orcid":"https://orcid.org/0000-0003-0386-419X","observed_orcids":["https://orcid.org/0000-0003-0386-419X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. E. Kun","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111800824","display_name":"Shingjie Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Wu","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114087673","display_name":"X. Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Xiong","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Williams","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039864062","display_name":"Amar J. Gajjar","orcid":"https://orcid.org/0000-0001-5019-0699","observed_orcids":["https://orcid.org/0000-0001-5019-0699"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Gajjar","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113599400","display_name":"Fredrick A. Boop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. A. Boop","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":null,"display_name":"R. A. Sanford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. Sanford","raw_affiliation_strings":["St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"8533","last_page":"8533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/juvenile-pilocytic-astrocytoma","display_name":"juvenile pilocytic astrocytoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/radiation-induced-cognitive-impairment","display_name":"radiation-induced cognitive impairment","score":0.550000011920929},{"id":"https://openalex.org/keywords/radiation-induced-hearing-loss","display_name":"radiation-induced hearing loss","score":0.8799999952316284},{"id":"https://openalex.org/keywords/radiation-dose-reduction","display_name":"radiation dose reduction","score":0.4580000042915344},{"id":"https://openalex.org/keywords/clinical-target-volume","display_name":"clinical target volume","score":0.746999979019165},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.8320000171661377},{"id":"https://openalex.org/keywords/optic-pathway-tumors","display_name":"optic pathway tumors","score":0.800000011920929},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.47099998593330383},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.37400001287460327},{"id":"https://openalex.org/keywords/acth-deficiency","display_name":"ACTH deficiency","score":0.5789999961853027},{"id":"https://openalex.org/keywords/growth-failure","display_name":"growth failure","score":0.40400001406669617},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9481626749038696},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5621023178100586},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4177112281322479},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3284730613231659}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.8533","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8533","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.8533","doi":"https://doi.org/10.1200/jco.2004.22.90140.8533","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.8533","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996811489","https://openalex.org/W2144778499","https://openalex.org/W7095420869","https://openalex.org/W2119449786","https://openalex.org/W2114414730","https://openalex.org/W2096151050","https://openalex.org/W2009857910","https://openalex.org/W2143806337","https://openalex.org/W2045613157","https://openalex.org/W1984405002"],"abstract_inverted_index":{"8533":[0],"Background:":[1],"A":[2,182],"phase":[3],"II":[4],"trial":[5],"of":[6,26,46,60,98,158,176,249,271,277,300,307],"conformal":[7],"radiation":[8,314],"therapy":[9],"(CRT)":[10],"was":[11,83,135,150,244,265],"conducted":[12],"to":[13,38,44,69,137,174,211,263,282,321],"determine":[14],"if":[15],"the":[16,24,40,116,123,217,247,268,304],"irradiated":[17],"volume":[18,78,276],"could":[19],"be":[20,280,310],"reduced":[21,281],"without":[22,286],"affecting":[23,251,287],"rate":[25,299],"disease":[27,288],"control":[28,289],"for":[29,187,216],"pediatric":[30],"patients":[31,109,129,162,234,250],"with":[32,67,93,110,154,170,235,294],"localized":[33,291],"low-grade":[34],"astrocytoma":[35,113],"(LGA)":[36],"and":[37,42,54,101,122,133,201,225,238,256,303],"estimate":[39,149],"incidence":[41],"time":[43,173,269],"onset":[45],"clinically":[47],"significant":[48,318],"CNS":[49],"effects.":[50],"Methods:":[51],"Between":[52],"8/97":[53],"1/03,":[55],"49":[56],"children":[57],"(median":[58],"age":[59],"8.7":[61],"\u00b1":[62,152],"4.0":[63],"yrs)":[64],"were":[65,90,208,230],"treated":[66],"CRT":[68,215],"54":[70],"Gy":[71],"using":[72,312],"a":[73,155,171,283,297],"10mm":[74,284],"anatomically-defined":[75],"clinical":[76],"target":[77],"(CTV).":[79],"The":[80,105,144,220,275],"median":[81,156,172],"CTV":[82,285],"89.3":[84],"cc":[85],"(range,":[86],"13.3\u2013340.9":[87],"cc).":[88],"Patients":[89,293],"evaluated":[91],"serially":[92],"psychometric":[94],"testing,":[95],"provocative":[96],"tests":[97],"endocrine":[99],"function":[100],"standardized":[102],"audiometry.":[103],"Results:":[104],"study":[106],"included":[107],"mainly":[108],"juvenile":[111],"pilocytic":[112],"(n=31)":[114],"involving":[115],"diencephalon":[117],"or":[118,141,166],"optic":[119,239],"pathway":[120,240],"(n=38)":[121],"majority":[124,248],"had":[125,130],"visual":[126,202,226],"impairment.":[127],"Fourteen":[128],"prior":[131],"chemotherapy":[132],"surgery":[134],"limited":[136,311],"subtotal":[138],"resection":[139],"(n=21)":[140],"biopsy":[142],"(n=20).":[143],"4-year":[145],"actuarial":[146],"event-free":[147],"survival":[148],"84.2%":[151],"9.3%":[153],"follow-up":[157],"31.0":[159],"months.":[160],"Six":[161],"experienced":[163],"local":[164],"(n=3)":[165,168],"distant":[167],"failure":[169,175],"18":[177],"months":[178,213],"(range":[179],"5\u201354":[180],"months).":[181],"slight":[183],"decline":[184],"in":[185,233,246,290],"scores":[186],"estimated":[188],"IQ":[189],"(\u22120.21":[190],"pts/yr;":[191],"p=0.003),":[192],"reading":[193,223],"(\u22120.23":[194],"pts/yr,":[195,199,206],"p=0.008),":[196],"spelling":[197],"(\u22120.19":[198],"p=0.02)":[200],"auditory":[203,227],"learning":[204,228],"(\u22120.16":[205],"p=0.06)":[207],"noted":[209],"up":[210],"48":[212],"after":[214],"entire":[218],"group.":[219],"effects":[221,306],"on":[222],"(p=0.044)":[224],"(p=0.016)":[229],"more":[231],"prominent":[232],"large":[236],"diencephalic":[237],"tumors.":[241],"Pre-CRT":[242],"endocrinopathy":[243,302],"observed":[245],"growth":[252],"(43%),":[253],"thyroid":[254],"(34%),":[255],"ACTH":[257],"(9%)":[258],"secretion.":[259],"Hearing":[260],"loss":[261],"due":[262],"CRT-alone":[264],"uncommon":[266],"during":[267],"interval":[270],"this":[272],"study.":[273],"Conclusions:":[274],"irradiation":[278],"may":[279,309],"LGA.":[292],"LGA":[295],"have":[296],"high":[298],"pre-existing":[301],"cognitive":[305],"treatment":[308],"focal":[313],"delivery":[315],"strategies.":[316],"No":[317],"financial":[319],"relationships":[320],"disclose.":[322]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}