{"id":"https://openalex.org/W4247897331","doi":"https://doi.org/10.2337/figshare.14334080.v1","title":"Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Co-Transporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice","display_name":"Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Co-Transporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice","publication_year":2021,"publication_date":"2021-04-05","ids":{"openalex":"https://openalex.org/W4247897331","doi":"https://doi.org/10.2337/figshare.14334080.v1"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.14334080.v1","doi":"https://doi.org/10.2337/figshare.14334080.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.14334080.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2337/figshare.14334080.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102017035","display_name":"Shuiling Zhao","orcid":"https://orcid.org/0000-0002-0769-5365","observed_orcids":["https://orcid.org/0000-0002-0769-5365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuiling Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034039022","display_name":"Chao\u2010Sheng Lo","orcid":"https://orcid.org/0000-0003-0645-7987","observed_orcids":["https://orcid.org/0000-0003-0645-7987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao-Sheng Lo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035952521","display_name":"Kana N. Miyata","orcid":"https://orcid.org/0000-0001-6486-4666","observed_orcids":["https://orcid.org/0000-0001-6486-4666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kana N. Miyata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035343244","display_name":"Anindya Ghosh","orcid":"https://orcid.org/0000-0002-8432-5288","observed_orcids":["https://orcid.org/0000-0002-8432-5288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anindya Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xinping Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinping Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000028694","display_name":"Isabelle Ch\u00e9nier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Chenier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055928047","display_name":"Jean\u2010Fran\u00e7ois Cailhier","orcid":"https://orcid.org/0000-0003-1659-298X","observed_orcids":["https://orcid.org/0000-0003-1659-298X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Francois Cailhier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053291645","display_name":"Jean H. Ethier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Ethier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079983507","display_name":"Jean\u2010Baptiste Lattouf","orcid":"https://orcid.org/0000-0002-8192-0508","observed_orcids":["https://orcid.org/0000-0002-8192-0508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Baptiste Lattouf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038048841","display_name":"J\u00e1nos G. Filep","orcid":"https://orcid.org/0000-0001-5022-3534","observed_orcids":["https://orcid.org/0000-0001-5022-3534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janos G. Filep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049720282","display_name":"Julie R. Ingelfinger","orcid":"https://orcid.org/0000-0001-9039-2703","observed_orcids":["https://orcid.org/0000-0001-9039-2703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie R. Ingelfinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101739209","display_name":"Shao\u2010Ling Zhang","orcid":"https://orcid.org/0000-0002-5255-6970","observed_orcids":["https://orcid.org/0000-0002-5255-6970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shao-Ling Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990846","display_name":"John S.D. Chan","orcid":"https://orcid.org/0000-0002-7137-454X","observed_orcids":["https://orcid.org/0000-0002-7137-454X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S.D. Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sglt2","display_name":"SGLT2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/renal-proximal-tubular-cells","display_name":"renal proximal tubular cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/diabetic-kidney-injury","display_name":"diabetic kidney injury","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dysglycemia","display_name":"dysglycemia","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oltipraz","display_name":"oltipraz","score":0.7829999923706055},{"id":"https://openalex.org/keywords/trigonelline","display_name":"trigonelline","score":0.8790000081062317},{"id":"https://openalex.org/keywords/akita-mice","display_name":"Akita mice","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6111392974853516},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5584502220153809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5418267250061035},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5288622975349426},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.46297189593315125},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4538496732711792},{"id":"https://openalex.org/C120405084","wikidata":"https://www.wikidata.org/wiki/Q285307","display_name":"Symporter","level":4,"score":0.43866872787475586},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41023680567741394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28987598419189453},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.21559402346611023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1894512176513672},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1291140913963318},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12263613939285278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09685847163200378}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.14334080.v1","doi":"https://doi.org/10.2337/figshare.14334080.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.14334080.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.14334080.v1","doi":"https://doi.org/10.2337/figshare.14334080.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.14334080.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396996991","https://openalex.org/W3011174938","https://openalex.org/W4393851348","https://openalex.org/W4397044355","https://openalex.org/W7222792918","https://openalex.org/W2771939547","https://openalex.org/W4386416002","https://openalex.org/W4399327177","https://openalex.org/W1993214221","https://openalex.org/W2059600600"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,46,120,125,129,141,144,171],"impact":[3],"of":[4,93,119,132,143,166,189],"nuclear":[5],"factor":[6,9],"erythroid":[7],"2-related":[8],"2":[10,27],"(Nrf2)":[11],"overexpression":[12,59],"in":[13,30,77,103,124,170,199],"renal":[14],"proximal":[15],"tubular":[16],"cells":[17],"(RPTCs)":[18],"on":[19,134],"blood":[20,64,194],"glucose,":[21,65],"kidney":[22,197],"injury":[23,198],"and":[24,74,99,105,154,168,192,196],"sodium-glucose":[25],"co-transporter":[26],"(Sglt2)":[28],"expression":[29,76,98,191],"diabetic":[31],"Akita":[32,78,85],"Nrf2-/-/Nrf2RPTC":[33,79],"transgenic":[34],"(Tg)":[35],"mice.":[36],"Immortalized":[37],"human":[38,49],"RPTCs":[39,172],"(HK2)":[40],"stably":[41],"transfected":[42],"with":[43,53,62,161],"plasmid":[44],"containing":[45],"SGLT2":[47,97,100,126,135,145,169,190],"promoter,":[48],"kidneys":[50,174],"from":[51,159,175],"patients":[52,160,176],"diabetes":[54,162],"were":[55,108],"also":[56],"studied.":[57],"Nrf2":[58],"was":[60,147],"associated":[61],"increased":[63],"glomerular":[66],"filtration":[67],"rate,":[68],"urinary":[69],"albumin-creatinine":[70],"ratio,":[71],"tubulointerstitial":[72],"fibrosis":[73],"Sglt2":[75],"Tg":[80],"mice":[81],"compared":[82],"to":[83,140],"their":[84],"Nrf2-/-":[86],"littermates.":[87],"In":[88],"vitro,":[89],"oltipraz":[90,133],"or":[91,112],"transfection":[92],"NRF2":[94,113,138,167,186],"cDNA":[95],"stimulated":[96],"promoter":[101,127,136,146],"activity":[102],"HK2,":[104],"these":[106],"effects":[107],"inhibited":[109],"by":[110,149,184],"trigonelline":[111],"small":[114],"interfering":[115],"RNA.":[116],"The":[117],"deletion":[118],"NRF2-responsive":[121],"element":[122],"(NRF2-RE)":[123],"abolished":[128],"stimulatory":[130],"effect":[131],"activity.":[137],"binding":[139],"NRF2-RE":[142],"confirmed":[148],"gel":[150],"mobility":[151],"shift":[152],"assay":[153],"chromatin":[155],"immunoprecipitation":[156],"assays.":[157],"Kidneys":[158],"exhibited":[163],"higher":[164],"levels":[165],"than":[173],"without":[177],"diabetes.":[178,200],"These":[179],"results":[180],"suggest":[181],"a":[182],"link":[183],"which":[185],"mediates":[187],"hyperglycemia-stimulation":[188],"exacerbates":[193],"glucose":[195]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-12T00:00:00"}
