{"id":"https://openalex.org/W4247774385","doi":"https://doi.org/10.1309/c8t8ynb4g3w45prf","title":"Comparison of Three Methods for Measuring Factor VIII Levels in Plasma","display_name":"Comparison of Three Methods for Measuring Factor VIII Levels in Plasma","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W4247774385","doi":"https://doi.org/10.1309/c8t8ynb4g3w45prf","pmid":"https://pubmed.ncbi.nlm.nih.gov/12866370"},"language":"en","primary_location":{"id":"doi:10.1309/c8t8ynb4g3w45prf","doi":"https://doi.org/10.1309/c8t8ynb4g3w45prf","is_oa":false,"landing_page_url":"https://doi.org/10.1309/c8t8ynb4g3w45prf","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077995419","display_name":"Wayne Leslie Chandler","orcid":"https://orcid.org/0000-0002-0431-7633","observed_orcids":["https://orcid.org/0000-0002-0431-7633"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne L. Chandler, MD","raw_affiliation_strings":["Dept of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195, USA","Department of Laboratory Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111564703","display_name":"Chris Ferrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Ferrell, MT(ASCP)","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045212145","display_name":"Joo Sang Lee","orcid":"https://orcid.org/0000-0001-8564-0848","observed_orcids":["https://orcid.org/0000-0001-8564-0848"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joo Lee, MT(ASCP)","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017583788","display_name":"Theingi Tun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theingi Tun, MT(ASCP)","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004432715","display_name":"Hien Kha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hien Kha, MT(ASCP)","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.44796155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"120","issue":"1","first_page":"34","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.953000009059906},{"id":"https://openalex.org/keywords/chromogenic-assay","display_name":"chromogenic assay","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.8140000104904175},{"id":"https://openalex.org/keywords/assay-comparison","display_name":"assay comparison","score":0.7390000224113464},{"id":"https://openalex.org/keywords/assay-interference","display_name":"assay interference","score":0.7519999742507935},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lepirudin","display_name":"lepirudin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.800000011920929},{"id":"https://openalex.org/keywords/assay-precision","display_name":"assay precision","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C128463046","wikidata":"https://www.wikidata.org/wiki/Q22315590","display_name":"Chromogenic","level":2,"score":0.9419274926185608},{"id":"https://openalex.org/C2780205058","wikidata":"https://www.wikidata.org/wiki/Q3271949","display_name":"Lepirudin","level":5,"score":0.823968768119812},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.7145000696182251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6227920651435852},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5033549666404724},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.4729297459125519},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4578269124031067},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.4255012571811676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34916770458221436},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22673815488815308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20302215218544006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20093655586242676},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.1885424554347992},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.14816200733184814},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.1331806480884552}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002863","descriptor_name":"Chromogenic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1309/c8t8ynb4g3w45prf","doi":"https://doi.org/10.1309/c8t8ynb4g3w45prf","is_oa":false,"landing_page_url":"https://doi.org/10.1309/c8t8ynb4g3w45prf","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"doi:10.1309/c8t8-ynb4-g3w4-5prf","doi":"https://doi.org/10.1309/c8t8-ynb4-g3w4-5prf","is_oa":false,"landing_page_url":"https://doi.org/10.1309/c8t8-ynb4-g3w4-5prf","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:12866370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12866370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W168978929","https://openalex.org/W1509399724","https://openalex.org/W1552949528","https://openalex.org/W1889830552","https://openalex.org/W1990107586","https://openalex.org/W1998755481","https://openalex.org/W2003418585","https://openalex.org/W2014487342","https://openalex.org/W2053351646","https://openalex.org/W2102193722","https://openalex.org/W2131384825","https://openalex.org/W2147383560","https://openalex.org/W2157807467","https://openalex.org/W2161800214","https://openalex.org/W2337281790","https://openalex.org/W2410432502","https://openalex.org/W2420484807","https://openalex.org/W4285719527","https://openalex.org/W4324114350","https://openalex.org/W6639812722"],"related_works":["https://openalex.org/W1801172270","https://openalex.org/W84925487","https://openalex.org/W3092675591","https://openalex.org/W2040219980","https://openalex.org/W2058683123","https://openalex.org/W3120264649","https://openalex.org/W2024498813","https://openalex.org/W4414160044","https://openalex.org/W2131384825","https://openalex.org/W1854248427"],"abstract_inverted_index":{"We":[0],"compared":[1],"1-stage":[2,47,64,93],"clot-based,":[3],"chromogenic,":[4],"and":[5,49,57,66,126],"immunoassay":[6],"methods":[7],"for":[8,34],"measuring":[9],"factor":[10,24,35,51,68,102,108],"VIII":[11,36,52,69,103,109],"in":[12,84,88,91],"plasma":[13],"with":[14,123],"a":[15],"focus":[16],"on":[17],"the":[18,30,46,58,63,85,92,98,106,113,119],"measurement":[19],"of":[20,23,76],"elevated":[21],"levels":[22,37],"VIII.":[25],"The":[26,41,74],"chromogenic":[27,50,99,107],"assay":[28,95,111],"showed":[29],"best":[31,42,120],"interassay":[32],"imprecision":[33],"near":[38],"150":[39],"IU/dL.":[40],"correlation":[43,60,122],"was":[44,61,112],"between":[45,62],"clot-based":[48,65,94],"assays":[53,70],"(r2":[54,71],"=":[55,72],"0.934),":[56],"lowest":[59],"antigenic":[67,101],"0.821).":[73],"presence":[75],"heparin,":[77,79,130,132],"low-molecular-weight":[78,131],"lepirudin,":[80,133],"or":[81,100,134],"lupus":[82,135],"inhibitors":[83],"sample":[86],"resulted":[87],"major":[89],"interference":[90,128],"but":[96],"not":[97],"assays.":[104],"Overall,":[105],"activity":[110],"optimal":[114],"method,":[115],"showing":[116],"good":[117],"precision,":[118],"overall":[121],"other":[124],"assays,":[125],"no":[127],"from":[129],"inhibitors.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}