{"id":"https://openalex.org/W4247657967","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.557","title":"Clinical characteristics and outcomes of patients with advanced hepatocellular carcinoma treated with immunotherapy: A real-world retrospective study.","display_name":"Clinical characteristics and outcomes of patients with advanced hepatocellular carcinoma treated with immunotherapy: A real-world retrospective study.","publication_year":2020,"publication_date":"2020-02-01","ids":{"openalex":"https://openalex.org/W4247657967","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.557"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2020.38.4_suppl.557","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.557","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.4_suppl.557","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080935663","display_name":"Adel Chergui","orcid":"https://orcid.org/0000-0003-1421-6032","observed_orcids":["https://orcid.org/0000-0003-1421-6032"]},"institutions":[{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adel Chergui","raw_affiliation_strings":["Jacobi Medical Center, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobi Medical Center, Bronx, NY;","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049068614","display_name":"Eswar Gadde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eswar Gadde","raw_affiliation_strings":["Montefiore Medical Center, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY;","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067840307","display_name":"Seda Serra Tolu","orcid":"https://orcid.org/0000-0003-2235-4902","observed_orcids":["https://orcid.org/0000-0003-2235-4902"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seda Serra Tolu","raw_affiliation_strings":["Montefiore Medical Center, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY;","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053494596","display_name":"Ana Acu\u00f1a-Villaordu\u00f1a","orcid":"https://orcid.org/0000-0003-0180-2972","observed_orcids":["https://orcid.org/0000-0003-0180-2972"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Acuna-Villaorduna","raw_affiliation_strings":["Montefiore Medical Center, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY;","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084119820","display_name":"Rafi Kabarriti","orcid":"https://orcid.org/0000-0001-7835-718X","observed_orcids":["https://orcid.org/0000-0001-7835-718X"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafi Kabarriti","raw_affiliation_strings":["Montefiore Medical Center, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Bronx, NY;","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029455802","display_name":"Sanjay Goel","orcid":"https://orcid.org/0000-0002-2798-7568","observed_orcids":["https://orcid.org/0000-0002-2798-7568"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Goel","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001637416","display_name":"Andreas Kaubisch","orcid":"https://orcid.org/0000-0003-3410-664X","observed_orcids":["https://orcid.org/0000-0003-3410-664X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Kaubisch","raw_affiliation_strings":["Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"4_suppl","first_page":"557","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-hepatocellular-carcinoma","display_name":"advanced hepatocellular carcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9959999918937683},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9399999976158142},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/meld-score","display_name":"MELD score","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hepatitis-b-and-c","display_name":"hepatitis B and C","score":0.621999979019165},{"id":"https://openalex.org/keywords/intravascular-invasion","display_name":"intravascular invasion","score":0.7590000033378601},{"id":"https://openalex.org/keywords/extrahepatic-metastases","display_name":"extrahepatic metastasis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.6110000014305115},{"id":"https://openalex.org/keywords/multiethnic-cohort","display_name":"multi-ethnic cohort","score":0.6779999732971191},{"id":"https://openalex.org/keywords/local-treatment","display_name":"local therapy","score":0.39100000262260437},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5189999938011169},{"id":"https://openalex.org/keywords/accelerated-approval","display_name":"accelerated approval","score":0.4129999876022339},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.32899999618530273},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9658299684524536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7017591595649719},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6751185655593872},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.5573140978813171},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4903740882873535},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4732249975204468},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44101908802986145},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.43556857109069824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4210259020328522},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3587616980075836},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35434162616729736},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33373773097991943}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2020.38.4_suppl.557","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.557","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.4_suppl.557","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979785966","https://openalex.org/W7170182914","https://openalex.org/W3109523281","https://openalex.org/W4386011110","https://openalex.org/W4389159783","https://openalex.org/W2947250851","https://openalex.org/W7170167732","https://openalex.org/W4415898987","https://openalex.org/W4384661866","https://openalex.org/W4308384305"],"abstract_inverted_index":{"557":[0],"Background:":[1],"Advanced":[2],"HCC":[3,39,47,283],"is":[4,25,29,284],"an":[5],"aggressive":[6],"malignancy":[7],"with":[8,42,46,49,286],"dismal":[9],"prognosis.":[10],"Newer":[11],"agents,":[12],"including":[13],"immunotherapy":[14],"(IT),":[15],"have":[16],"been":[17],"granted":[18],"accelerated":[19],"approval.":[20],"Information":[21],"outside":[22],"clinical":[23,34],"trials":[24],"scarce.":[26],"This":[27],"study":[28],"aimed":[30],"to":[31,79,94,187,193],"describe":[32],"the":[33,54,202,273,278,297],"characteristics":[35,66],"and":[36,64,84,97,133,143,153,161,176,190,210,224,229,313],"outcomes":[37],"of":[38,91,107,168,277,280,303],"patients":[40,255],"treated":[41,48,258],"IT.":[43],"Methods:":[44],"Patients":[45],"IT":[50,281,304],"were":[51,67,99,118,121,156,257],"identified":[52],"using":[53,101],"institutional":[55],"data-mining":[56],"software,":[57],"Clinical":[58],"Looking":[59],"Glass.":[60],"Patient":[61],"demographics,":[62],"clinical,":[63],"treatment":[65,77,184,192,206,233],"collected.":[68],"Progression-free":[69],"survival":[70,252],"(PFS)":[71],"was":[72,138,147,171,185,198,220,225,242,247],"defined":[73],"as":[74,87,204,211,305],"time":[75,88],"from":[76,89],"initiation":[78],"disease":[80,93],"progression":[81],"or":[82],"death,":[83],"overall-survival":[85],"(OS)":[86],"diagnosis":[90],"advanced":[92],"death.":[95],"PFS":[96,219,312],"OS":[98,241,289],"plotted":[100],"Kaplan-Meier":[102],"curves.":[103],"Results:":[104],"A":[105],"total":[106],"52":[108],"patients;":[109],"median":[110,144,218,240,288],"age":[111],"64":[112],"years;":[113],"male":[114],"predominance":[115],"(38,":[116],"73.1%)":[117],"identified.":[119],"There":[120],"24":[122],"(54.5%)":[123],"Hispanics,":[124],"9":[125],"(20.5%)":[126],"Non-Hispanic":[127,131],"Blacks,":[128],"7":[129,180],"(15.9%)":[130],"White":[132],"4":[134],"(9.1%)":[135],"Asians.":[136],"Cirrhosis":[137],"seen":[139,172],"in":[140,158,173,179,200,207,215,227,254,259,282,311],"41":[141],"(83.7%),":[142],"MELD":[145],"score":[146],"8":[148],"(IQ:":[149],"7-10).":[150],"Hepatitis":[151],"B":[152],"C":[154],"infection":[155],"encountered":[157],"12":[159],"(24.5%)":[160],"22":[162],"(44%)":[163],"patients,":[164],"respectively.":[165],"Imaging":[166],"evidence":[167],"intravascular":[169],"invasion":[170],"16":[174],"(34.8%)":[175],"extrahepatic":[177],"metastases":[178],"(14.9%)":[181],"cases.":[182],"Local":[183],"provided":[186],"29":[188],"(59.2%)":[189],"radiation":[191],"14":[194],"(28.6%)":[195],"patients.":[196],"Nivolumab":[197],"used":[199],"all":[201],"cases,":[203],"first-line":[205,228],"17":[208],"(32.7%)":[209],"\u2265":[212,230,260],"second":[213,231,261,308],"line":[214,232,262,309],"35(67.3%).":[216],"The":[217,239],"6.2":[221],"(3.1-10.6)":[222],"months":[223],"similar":[226],"(8":[234],"vs":[235,264],"5.9":[236],"months,":[237,266],"p=0.90).":[238],"24.2":[243],"(18-28)":[244],"months;":[245],"there":[246],"a":[248,287],"tendency":[249],"towards":[250],"higher":[251],"rates":[253],"that":[256],"(16.8":[263],"25.2":[265],"0=0.07).":[267],"Conclusions:":[268],"In":[269],"this":[270],"multiethnic":[271],"cohort,":[272],"\u201creal":[274],"world\u201d":[275],"experience":[276],"benefit":[279],"encouraging,":[285],"exceeding":[290],"two":[291],"years.":[292],"Expanded":[293],"data":[294],"may":[295],"elucidate":[296],"differences":[298],"if":[299],"any,":[300],"between":[301],"use":[302],"front":[306],"vs.":[307],"therapy,":[310],"OS.":[314]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}