{"id":"https://openalex.org/W4247623665","doi":"https://doi.org/10.1159/000139521","title":"Subcellular Distribution of SERCA and Calcium-Activated ATPase in Rabbit and Human Urinary Bladder Smooth Muscle","display_name":"Subcellular Distribution of SERCA and Calcium-Activated ATPase in Rabbit and Human Urinary Bladder Smooth Muscle","publication_year":2008,"publication_date":"2008-06-10","ids":{"openalex":"https://openalex.org/W4247623665","doi":"https://doi.org/10.1159/000139521","pmid":"https://pubmed.ncbi.nlm.nih.gov/9346402"},"language":"en","primary_location":{"id":"doi:10.1159/000139521","doi":"https://doi.org/10.1159/000139521","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000139521","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Levin","raw_affiliation_strings":["Albany College of Pharmacy, Stratton Veterans Affairs Medical Center, N.Y. 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany College of Pharmacy, Stratton Veterans Affairs Medical Center, N.Y. 12208, USA","institution_ids":["https://openalex.org/I365282","https://openalex.org/I4210109456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085288013","display_name":"Tamar J. Nicholas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamar J. Nicholas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052469762","display_name":"Gail G. Snitkoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gail G. Snitkoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111874369","display_name":"James Mandell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Mandell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070957952","display_name":"David H. Russell","orcid":"https://orcid.org/0000-0003-0830-3914","observed_orcids":["https://orcid.org/0000-0003-0830-3914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Russell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048451603","display_name":"Harry J. Wilbur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry J. Wilbur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046606426","display_name":"Laura J. Mogavero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J. Mogavero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7651,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77638349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"55","issue":"3","first_page":"136","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.9380000233650208},{"id":"https://openalex.org/keywords/calcium-activated-atpase","display_name":"calcium-activated ATPase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bladder-smooth-muscle","display_name":"bladder smooth muscle","score":0.9269999861717224},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/microsomal-fraction","display_name":"microsomal fraction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mitochondrial-fraction","display_name":"mitochondrial fraction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.5099999904632568},{"id":"https://openalex.org/keywords/calcium-storage","display_name":"calcium storage","score":0.7289999723434448},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.48899999260902405},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.8640000224113464},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.8008167743682861},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.6053885817527771},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5980382561683655},{"id":"https://openalex.org/C101571972","wikidata":"https://www.wikidata.org/wiki/Q3396061","display_name":"Calcium ATPase","level":4,"score":0.5973390936851501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.519681990146637},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.5094192624092102},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.5075143575668335},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5073809027671814},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.45456957817077637},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.42751461267471313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41924482583999634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37279972434043884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3375634551048279},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33483707904815674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3303340673446655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29204922914505005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22498729825019836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18605810403823853},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000139521","doi":"https://doi.org/10.1159/000139521","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000139521","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:9346402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9346402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.40149998664855957,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3187029720","display_name":null,"funder_award_id":"1 RO 1 DK 26508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5634912814","display_name":"AUTONOMIC CONTROL OF LOWER URINARY TRACT FUNCTION","funder_award_id":"R01DK026508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063250488","https://openalex.org/W1970813153","https://openalex.org/W2044022979","https://openalex.org/W2066297417","https://openalex.org/W1995589178","https://openalex.org/W1977662916","https://openalex.org/W1988165477","https://openalex.org/W1988224530","https://openalex.org/W1988864069","https://openalex.org/W4391658567"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"demonstrated":[3,147],"that":[4,214,235],"calcium":[5,187,208],"storage":[6],"and":[7,37,72,83,93,107,119,140,171,185,196,206,224],"release":[8],"from":[9],"IP-3-dependent":[10],"sites":[11],"in":[12,20,49,157,162,236,244],"the":[13,21,25,45,57,69,94,120,141,150,158,165,177,193,198,211,216,220,227,237],"sarcoplasmic":[14],"reticulum":[15],"play":[16],"an":[17],"important":[18],"role":[19],"contractile":[22],"response":[23],"of":[24,44,47,59,86,112,152,164,180,201,210,215,222,226,251],"rabbit":[26,170,212,228,245],"urinary":[27,50,87],"bladder":[28,51,88,173,229,239],"to":[29,67,78,234],"both":[30,169,181,202],"field":[31],"stimulation":[32],"(mediated":[33],"via":[34],"neurotransmitter":[35],"release)":[36],"bethanechol":[38],"(direct":[39],"muscarinic":[40],"stimulation).":[41],"In":[42,218],"view":[43],"importance":[46],"SERCA":[48,60,121,153,223],"smooth":[52,89,174,230,240],"muscle":[53,90,231],"function,":[54],"we":[55],"studied":[56],"distribution":[58,221],"by":[61,73,101,125],"two":[62],"methods:":[63],"using":[64,76,128,136],"Western":[65,126],"blotting":[66,127],"quantitate":[68],"protein":[70,110,122],"concentration":[71,111,151],"enzyme":[74],"analysis":[75,139],"thapsigargin":[77,142],"specifically":[79],"inhibit":[80],"SERCA.":[81],"Rabbit":[82],"human":[84,172,238,252],"samples":[85],"were":[91,189,246],"homogenized":[92],"homogenate":[95],"separated":[96],"into":[97],"three":[98,114,194],"particulate":[99,115],"fractions":[100,116,167],"differential":[102],"centrifugation:":[103],"nuclear-cell":[104],"wall,":[105],"mitochondrial,":[106],"microsomal.":[108],"The":[109,131,145],"these":[113],"was":[117,134,154,232],"determined":[118],"level":[123],"quantitated":[124,135],"SERCA-2":[129],"antibodies.":[130],"calcium-ATPase":[132,225],"activity":[133,200],"standard":[137],"enzymatic":[138,178,199],"sensitivity":[143],"determined.":[144],"results":[146],"that:":[148],"(1)":[149],"significantly":[155,247],"greater":[156,248],"microsomal":[159],"fraction":[160],"than":[161,249],"either":[163],"other":[166],"for":[168],"muscle;":[175],"(2)":[176],"activities":[179,243],"total":[182,203],"calcium-activated":[183,204],"ATPase":[184,188,205,209],"thapsigargin-sensitive":[186,207],"evenly":[190],"divided":[191],"among":[192],"fractions,":[195],"(3)":[197],"exceeded":[213],"human.":[217],"conclusion,":[219],"similar":[233],"muscle,":[241],"although":[242],"those":[250],"tissue.":[253]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}