{"id":"https://openalex.org/W4247429259","doi":"https://doi.org/10.1016/s0924-977x(03)90001-0","title":"Molecular mechanisms of tolerance to and withdrawal of GABAA receptor modulators","display_name":"Molecular mechanisms of tolerance to and withdrawal of GABAA receptor modulators","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W4247429259","doi":"https://doi.org/10.1016/s0924-977x(03)90001-0"},"language":"en","primary_location":{"id":"doi:10.1016/s0924-977x(03)90001-0","doi":"https://doi.org/10.1016/s0924-977x(03)90001-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-977x(03)90001-0","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090509427","display_name":"Giovanni Biggio","orcid":"https://orcid.org/0000-0003-2333-5535","observed_orcids":["https://orcid.org/0000-0003-2333-5535"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G. Biggio","raw_affiliation_strings":["Department of Experimental Biology \u201cBernardo Loddo\u201d, University of Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Biology \u201cBernardo Loddo\u201d, University of Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090509427"],"corresponding_institution_ids":["https://openalex.org/I172446870"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32311978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"S2","last_page":"S4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepine-tolerance","display_name":"benzodiazepine tolerance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.859000027179718},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenosine-receptor-agonists","display_name":"adenosine receptor agonists","score":0.7670000195503235},{"id":"https://openalex.org/keywords/adenosine-receptor-antagonists","display_name":"adenosine receptor antagonists","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.7860000133514404},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.5609999895095825},{"id":"https://openalex.org/keywords/gaba-a-receptor-modulators","display_name":"GABA-A receptor modulators","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2776992512","wikidata":"https://www.wikidata.org/wiki/Q28208900","display_name":"Adenosinergic","level":5,"score":0.9835660457611084},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.8584007024765015},{"id":"https://openalex.org/C2780231331","wikidata":"https://www.wikidata.org/wiki/Q5010992","display_name":"CGS-21680","level":5,"score":0.6129177808761597},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6084334254264832},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.605510413646698},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5748106241226196},{"id":"https://openalex.org/C2780634109","wikidata":"https://www.wikidata.org/wiki/Q18350222","display_name":"Adenosine receptor antagonist","level":5,"score":0.539027750492096},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5361774563789368},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5305236577987671},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5276424288749695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5196613073348999},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5066240429878235},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.48404425382614136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45964479446411133},{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.45424848794937134},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.44685134291648865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3795032501220703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32167744636535645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0924-977x(03)90001-0","doi":"https://doi.org/10.1016/s0924-977x(03)90001-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-977x(03)90001-0","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1647312149","https://openalex.org/W1983621709","https://openalex.org/W1998691527","https://openalex.org/W2019376092","https://openalex.org/W2076076801","https://openalex.org/W2109392677"],"related_works":["https://openalex.org/W2001036455","https://openalex.org/W7100795505","https://openalex.org/W2108694451","https://openalex.org/W1793250547","https://openalex.org/W1979789823","https://openalex.org/W7096835321","https://openalex.org/W1782731057","https://openalex.org/W219440993","https://openalex.org/W2029483486","https://openalex.org/W2013683917"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
