{"id":"https://openalex.org/W4247420587","doi":"https://doi.org/10.21474/ijar01/12418","title":"THE ROLE OF HYBRID BRACHYTHERAPY IN MANAGEMENT OF LOCALLY ADVANCED CERVICAL CANCER: DOSIMETRIC STUDY AND INITIAL RESULTS","display_name":"THE ROLE OF HYBRID BRACHYTHERAPY IN MANAGEMENT OF LOCALLY ADVANCED CERVICAL CANCER: DOSIMETRIC STUDY AND INITIAL RESULTS","publication_year":2021,"publication_date":"2021-02-28","ids":{"openalex":"https://openalex.org/W4247420587","doi":"https://doi.org/10.21474/ijar01/12418"},"language":"en","primary_location":{"id":"doi:10.21474/ijar01/12418","doi":"https://doi.org/10.21474/ijar01/12418","is_oa":true,"landing_page_url":"https://doi.org/10.21474/ijar01/12418","pdf_url":null,"source":{"id":"https://openalex.org/S4210206230","display_name":"International Journal of Advanced Research","issn_l":"2320-5407","issn":["2320-5407"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21474/ijar01/12418","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046922279","display_name":"M. Hommadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hommadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111032420","display_name":"H. Bakkali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Bakkali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021872781","display_name":"Oswald Houessou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Houessou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028371988","display_name":"Maroua Benlemlih","orcid":"https://orcid.org/0000-0003-4103-1295","observed_orcids":["https://orcid.org/0000-0003-4103-1295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Benlemlih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043318696","display_name":"T. El Morjani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Elmorjani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073988666","display_name":"N. Bendahou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Bendahou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077083609","display_name":"I. Lahdiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Lahdiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010882316","display_name":"Saber Boutayeb","orcid":"https://orcid.org/0000-0003-1642-9330","observed_orcids":["https://orcid.org/0000-0003-1642-9330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Boutayeb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057470769","display_name":"S. El Mejjaoui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. El mejjaoui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074447937","display_name":"H. el Kacemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kacemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069280525","display_name":"Tayeb Kebdani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Kebdani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036021476","display_name":"N. Benjaafar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Benjaafar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37291481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"02","first_page":"61","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hybrid-brachytherapy","display_name":"hybrid brachytherapy","score":0.902999997138977},{"id":"https://openalex.org/keywords/locally-advanced-cervical-cancer","display_name":"locally advanced cervical cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/hdr-brachytherapy","display_name":"high-dose-rate brachytherapy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/intracavitary-brachytherapy","display_name":"intracavitary brachytherapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/interstitial-brachytherapy","display_name":"interstitial brachytherapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mri-based-treatment-planning","display_name":"MRI-based treatment planning","score":0.906000018119812},{"id":"https://openalex.org/keywords/high-risk-clinical-target-volume","display_name":"high-risk clinical target volume","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bladder-sparing","display_name":"bladder sparing","score":0.6460000276565552},{"id":"https://openalex.org/keywords/rectum-sparing","display_name":"rectum sparing","score":0.9070000052452087},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.656000018119812},{"id":"https://openalex.org/keywords/clinical-feasibility","display_name":"clinical feasibility","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2910158674","wikidata":"https://www.wikidata.org/wiki/Q2051688","display_name":"Parametrial","level":5,"score":0.9459836483001709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8180767297744751},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.7909749746322632},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.750472903251648},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.5271788835525513},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5111914277076721},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.47709164023399353},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.44230878353118896},{"id":"https://openalex.org/C2993195994","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical carcinoma","level":4,"score":0.3179515600204468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30672919750213623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08211544156074524}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21474/ijar01/12418","doi":"https://doi.org/10.21474/ijar01/12418","is_oa":true,"landing_page_url":"https://doi.org/10.21474/ijar01/12418","pdf_url":null,"source":{"id":"https://openalex.org/S4210206230","display_name":"International Journal of Advanced Research","issn_l":"2320-5407","issn":["2320-5407"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21474/ijar01/12418","doi":"https://doi.org/10.21474/ijar01/12418","is_oa":true,"landing_page_url":"https://doi.org/10.21474/ijar01/12418","pdf_url":null,"source":{"id":"https://openalex.org/S4210206230","display_name":"International Journal of Advanced Research","issn_l":"2320-5407","issn":["2320-5407"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4384938837","https://openalex.org/W2503910888","https://openalex.org/W4387421951","https://openalex.org/W2949163816","https://openalex.org/W4283526783","https://openalex.org/W2128768289","https://openalex.org/W4313586327","https://openalex.org/W2517611368","https://openalex.org/W4402906782","https://openalex.org/W2949759859"],"abstract_inverted_index":{"Purpose:The":[0],"aims":[1],"of":[2,18,87,103,120,126,142,173,196,226,247,287,292,322,338,386,401],"this":[3,80],"study":[4,259],"were":[5,58,77,137,239,250,261],"to":[6,12,92,115,179,236,266,352,382],"investigate":[7],"the":[8,104,117,132,140,147,152,174,197,215,218,224,267,383],"clinical":[9,153,171,363],"feasibility":[10],"and":[11,28,43,47,134,200,223,243,257,308,369,392,397],"report":[13],"our":[14],"preliminary":[15,362],"treatment":[16,33,99,185],"outcomes":[17],"combined":[19,367],"intracavitary/interstitial":[20],"brachytherapy":[21,122,373],"(IC/IS":[22,157],"BT),":[23],"using":[24],"a":[25,206,245,398],"hybrid":[26,65,83,175],"applicator":[27,84,176,188,229],"magnetic":[29],"resonance":[30],"imaging":[31],"(MRI)based":[32],"planning":[34],"in":[35,110,182,220,230,232,254,374],"patients":[36,51,112,333,375],"with":[37,52,60,68,97,159,228,376],"locally":[38,53],"advanced":[39,54],"cervical":[40,56],"cancer.":[41],"Methods":[42],"Materials:Between":[44],"January":[45],"2017":[46],"December":[48],"2018,":[49],"eight":[50,237],"uterine":[55],"cancer":[57],"treated":[59],"primary":[61],"radiation":[62],"therapy":[63,389],"including":[64],"BT.":[66],"Patients":[67],"distant":[69,335],"metastasis":[70,336],"other":[71],"than":[72],"para-aortic":[73],"lymph":[74],"node":[75],"spread":[76],"excluded":[78],"from":[79],"study.":[81],"A":[82],"for":[85,208,263,298],"guidance":[86],"parametrial":[88],"needles":[89,238,249],"was":[90,113,213,277],"used":[91],"perform":[93],"high-dose-rate-brachytherapy":[94],"(HDR":[95],"BT)":[96],"MRIbased":[98],"pre-planning.":[100],"Parametrial":[101],"extent":[102,141],"disease":[105,109,379],"or":[106,192,347],"large":[107],"residual":[108,143,378],"these":[111],"judged":[114],"exceed":[116],"coverage":[118],"limit":[119],"intracavitary":[121,368],"alone.":[123],"The":[124,170,187],"number":[125],"needles,":[127],"chosen":[128],"guiding":[129],"holes":[130],"through":[131],"ovoids,":[133],"insertion":[135],"depths":[136],"based":[138,372],"on":[139],"disease.":[144],"We":[145],"investigated":[146],"dosimetric":[148],"gain":[149,286],"by":[150],"comparing":[151],"interstitial":[154,190,194,370],"optimized":[155,163],"plan":[156,164,256,260],"clinical)":[158],"an":[160,284,319],"additionally":[161],"generated":[162],"without":[165],"needle":[166,209,353],"use":[167,172],"(ICstudy).":[168],"Results:":[169],"system":[177],"proved":[178],"be":[180],"feasible":[181,391],"all":[183],"32":[184],"fractions.":[186],"Fletcher":[189],"6mm":[191],"Utrecht":[193],"consists":[195],"IC":[198,258],"tandem":[199],"two":[201,337],"ovoids":[202],"that":[203,366],"serves":[204],"as":[205,345],"template":[207],"insertion.":[210],"MRI":[211],"preplanning":[212],"performed":[214],"week":[216],"before":[217],"implant":[219],"5":[221],"cases":[222],"day":[225],"application":[227,265],"place":[231],"3":[233],"cases.":[234],"Four":[235],"placed":[240],"per":[241],"fraction,":[242],"overall":[244],"total":[246],"152":[248],"used.":[251],"Significant":[252],"differences":[253],"IC/IS":[255],"derived":[262],"dose":[264],"target":[268,272],"volume":[269,273],"D90":[270],"high-riskclinical":[271],"(D90":[274],"CTV":[275],"HR)":[276],"90.1Gy":[278],"(IC/ISclinical)":[279,313],"vs":[280,303,314],"85.36":[281],"Gy(IC":[282],"study)with":[283],"average":[285,320],"4.74":[288],"Gy.":[289],"Likewise,":[290],"sparing":[291],"organs":[293],"at":[294],"risk":[295],"differed":[296],"significantly":[297],"bladder":[299],"D2cc:":[300,310],"82,5":[301],"Gy(IC/ISclinical)":[302],"95.7":[304],"Gy":[305,312,316],"(IC":[306,317],"study)":[307],"rectum":[309],"65,5":[311],"67.8":[315],"study).With":[318],"follow-up":[321],"27,25":[323],"months":[324],"(range":[325],"18\u201334):":[326],"no":[327,341],"patient":[328,356],"experienced":[329,334],"local":[330,395],"relapse,":[331],"three":[332],"them":[339],"died,":[340],"acute":[342],"complications":[343],"such":[344],"bleeding":[346],"organ":[348],"penetration":[349],"occurred":[350],"due":[351],"placement,":[354],"one":[355],"developed":[357],"recto-vaginal":[358],"fistula.":[359],"Conclusions:":[360],"Our":[361],"experience":[364],"indicates":[365],"MRI-":[371],"significant":[377],"extending":[380],"up":[381],"distal":[384],"third":[385],"parametriaafter":[387],"external-beam":[388],"is":[390],"allows":[393],"excellent":[394],"control":[396],"low":[399],"rate":[400],"morbidity.":[402]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}