{"id":"https://openalex.org/W4247315431","doi":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","title":"Letters to the Editor","display_name":"Letters to the Editor","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W4247315431","doi":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","pmid":"https://pubmed.ncbi.nlm.nih.gov/17489838"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1754.2007.01094.x","doi":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1754.2007.01094.x","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1754.2007.01094.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035808651","display_name":"Andrew S. Moore","orcid":"https://orcid.org/0000-0001-8062-1779","observed_orcids":["https://orcid.org/0000-0001-8062-1779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Moore","raw_affiliation_strings":["Conjoint Lecturer and","Paediatric Haematology-Oncology Fellow and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conjoint Lecturer and","institution_ids":[]},{"raw_affiliation_string":"Paediatric Haematology-Oncology Fellow and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113508025","display_name":"Ram Suppiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210148577","display_name":"Mater Children's Hospital","ror":"https://ror.org/04mxrtj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1316052090","https://openalex.org/I4210148577"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ram Suppiah","raw_affiliation_strings":["Consultant Paediatric Haematologist-Oncologist Department of Paediatric Haematology and Oncology Mater Children's Hospital","Senior Lecturer Discipline of Paediatrics and Child Health University of Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Paediatric Haematologist-Oncologist Department of Paediatric Haematology and Oncology Mater Children's Hospital","institution_ids":["https://openalex.org/I4210148577"]},{"raw_affiliation_string":"Senior Lecturer Discipline of Paediatrics and Child Health University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030645591","display_name":"Steven Weier","orcid":"https://orcid.org/0000-0002-7157-3784","observed_orcids":["https://orcid.org/0000-0002-7157-3784"]},"institutions":[{"id":"https://openalex.org/I1316052090","display_name":"Mater Health Services","ror":"https://ror.org/03mjtdk61","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1316052090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steven Weier","raw_affiliation_strings":["Senior Scientist Clinical Chemistry Department Mater Pathology Services Brisbane, Queensland Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Scientist Clinical Chemistry Department Mater Pathology Services Brisbane, Queensland Australia","institution_ids":["https://openalex.org/I1316052090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"5","first_page":"415","last_page":"416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.7770000100135803},{"id":"https://openalex.org/keywords/intravenous-fluids","display_name":"intravenous fluids","score":0.7099999785423279},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/t-cell-non-hodgkin-lymphoma","display_name":"T-cell non-Hodgkin lymphoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.8429999947547913},{"id":"https://openalex.org/keywords/serum-sodium","display_name":"serum sodium","score":0.5789999961853027},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.4480000138282776},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.49399998784065247},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9400941729545593},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.64350825548172},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5958871245384216},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5952274203300476},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5214342474937439},{"id":"https://openalex.org/C2776703092","wikidata":"https://www.wikidata.org/wiki/Q824292","display_name":"Hyponatremia","level":2,"score":0.5003528594970703},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4455912709236145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4446149468421936},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42498332262039185},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.41463032364845276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013086","descriptor_name":"Spermatic Cord Torsion","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013086","descriptor_name":"Spermatic Cord Torsion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013086","descriptor_name":"Spermatic Cord Torsion","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1754.2007.01094.x","doi":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1754.2007.01094.x","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},{"id":"pmid:17489838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17489838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of paediatrics and child health","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1111/j.1440-1754.2007.01094.x","doi":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1754.2007.01094.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1754.2007.01094.x","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4247315431.pdf","grobid_xml":"https://content.openalex.org/works/W4247315431.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2053332343"],"related_works":["https://openalex.org/W1989422285","https://openalex.org/W2053332343","https://openalex.org/W2569983332","https://openalex.org/W2511979415","https://openalex.org/W3024780139","https://openalex.org/W2978384249","https://openalex.org/W2542675347","https://openalex.org/W4400690758","https://openalex.org/W2937901167","https://openalex.org/W2017026252"],"abstract_inverted_index":{"22":[0],"December":[1,29,122],"2006":[2],"Dear":[3],"Editor,":[4],"RE:":[5],"HYPONATRAEMIA":[6],"AND":[7],"SEIZURES":[8],"IN":[9],"ONCOLOGY":[10],"PATIENTS":[11],"ASSOCIATED":[12],"WITH":[13],"HYPOTONIC":[14],"INTRAVENOUS":[15],"FLUIDS":[16],"We":[17,97],"read":[18],"with":[19,80,92,207,272,350,355,388],"interest":[20],"the":[21,28,33,48,64,114,129,164,168,208,221,273,337,344,377,393,401,435,470],"article":[22],"by":[23],"Duke":[24,389],"et":[25,390],"al.":[26,391],"in":[27,42,104,166,215,251,276,307,336,348,376,383],"2005":[30],"issue":[31],"of":[32,38,47,66,102,151,170,183,189,202,223,237,259,262,298,315,358,364,379,395,403,413,427,437,450,456,472,489],"Journal,":[34],"describing":[35],"three":[36,49,136],"cases":[37],"hyponatraemia":[39,103,171,190,238,299,347,365],"and":[40,54,121,135,268,408,415,452,468,503],"seizures":[41,335],"oncology":[43],"patients.":[44,217,340],"Only":[45],"one":[46,296,374],"patients":[50,79,105,125,144,185,196,249,321,349,360,399],"described":[51],"had":[52,186,198,254,311],"leukaemia":[53,83],"this":[55,445],"patient":[56,309,461],"was":[57,244,372],"not":[58,245],"receiving":[59],"hyper-hydration":[60,73,263,302,316,380],"for":[61,78,108,133,137,142,265,270,303,317,346,381,444,499],"chemotherapy":[62,382],"at":[63,113],"time":[65],"his":[67,500],"hyponatraemic":[68,326],"episode.1":[69],"In":[70],"our":[71,184,252,359,384],"unit,":[72],"is":[74,455],"most":[75],"commonly":[76],"used":[77],"acute":[81],"lymphoblastic":[82],"(ALL)":[84],"or":[85,94,110,205,287,352],"T-cell":[86,111,138,353],"non-Hodgkin's":[87],"lymphoma":[88],"(NHL)":[89],"being":[90,212,279],"treated":[91],"cyclophosphamide":[93],"high-dose":[95,266,318],"methotrexate.":[96,319],"therefore":[98],"conducted":[99],"an":[100,187,362],"audit":[101,130,253],"beginning":[106],"treatment":[107,127,224],"ALL":[109,134,351],"NHL":[112],"Mater":[115,493],"Children's":[116,494],"Hospital":[117],"between":[118],"January":[119],"2001":[120],"2005.":[123],"Forty-five":[124],"commenced":[126],"during":[128,225,301,324,466],"period,":[131],"42":[132],"NHL.":[139],"Biochemistry":[140],"results":[141],"these":[143,227],"were":[145,159,239,333],"reviewed":[146],"to":[147,162,234,241,400,420,481],"identify":[148],"all":[149],"episodes":[150,228,236],"serum":[152],"sodium":[153,200,210,285,292,451],"less":[154,366],"than":[155,367],"130":[156,174,193,368],"mmol/L.":[157,369],"Charts":[158],"then":[160],"examined":[161],"determine":[163],"context":[165],"which":[167,226],"episode":[169,188,297,363,375],"(sodium":[172,191],"<60;":[173,192],"mmol/L)":[175],"occurred.":[176,229],"Almost":[177],"one-third":[178,357],"(31.1%,":[179],"n":[180],"=":[181],"14)":[182],"mmol/L).":[194],"Five":[195],"(11.1%)":[197],"a":[199,256,308,422,460],"level":[201],"125":[203],"mmol/L":[204,214],"less,":[206],"lowest":[209],"recorded":[211],"122":[213],"two":[216],"Table":[218],"1":[219],"summarises":[220],"phase":[222],"A":[230],"detailed":[231],"analysis":[232],"as":[233,430],"whether":[235],"due":[240],"vincristine":[242],"alone":[243],"undertaken.":[246],"The":[247,411,425,478],"14":[248],"identified":[250],"received":[255,312],"collective":[257],"total":[258],"93":[260],"courses":[261],"(47":[264],"methotrexate":[267],"46":[269],"cyclophosphamide),":[271],"base":[274],"fluid":[275,453],"each":[277],"instance":[278],"either":[280],"3.3%":[281],"dextrose":[282,289],"+":[283,290],"0.3%":[284],"chloride":[286],"4%":[288],"0.18%":[291],"chloride.":[293],"Surprisingly,":[294],"only":[295,373],"occurred":[300,306],"chemotherapy.":[304],"This":[305],"who":[310],"3":[313],"days":[314],"Two":[320],"(4.4%)":[322],"died":[323],"their":[325],"episodes,":[327],"both":[328],"from":[329],"overwhelming":[330],"infection.":[331],"There":[332],"no":[334],"other":[338],"12":[339],"Our":[341],"findings":[342],"highlight":[343],"potential":[345],"NHL,":[354],"almost":[356],"having":[361],"While":[370],"there":[371],"setting":[378],"audit,":[385],"we":[386],"agree":[387],"that":[392,432],"use":[394,426,471],"hypotonic":[396,473],"fluids":[397],"exposes":[398],"risk":[402],"excessive":[404],"free":[405],"water":[406],"accumulation":[407],"iatrogenic":[409],"hyponatraemia.":[410],"periods":[412],"induction":[414,467],"re-induction":[416],"therapy":[417],"would":[418],"appear":[419],"pose":[421],"particular":[423],"risk.":[424,447],"agents":[428],"such":[429],"vincristine,":[431],"may":[433,441],"cause":[434],"syndrome":[436],"inappropriate":[438],"antidiuretic":[439],"hormone,":[440],"be":[442,476],"responsible":[443],"increased":[446],"Careful":[448],"monitoring":[449],"balance":[454],"critical":[457],"importance.":[458],"When":[459],"requires":[462],"parenteral":[463],"fluids,":[464],"particularly":[465],"re-induction,":[469],"solutions":[474],"should":[475],"avoided.":[477],"authors":[479],"wish":[480],"thank":[482],"Dr":[483],"Philip":[484],"Sargent,":[485],"Consultant":[486],"Intensivist,":[487],"Department":[488],"Paediatric":[490],"Intensive":[491],"Care,":[492],"Hospital,":[495],"Brishane,":[496],"Queensland,":[497],"Australia,":[498],"expert":[501],"opinion":[502],"advice.":[504]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}