{"id":"https://openalex.org/W4247119877","doi":"https://doi.org/10.1001/archderm.105.5.761","title":null,"display_name":null,"publication_year":1972,"publication_date":"1972-05-01","ids":{"openalex":"https://openalex.org/W4247119877","doi":"https://doi.org/10.1001/archderm.105.5.761"},"language":"en","primary_location":{"id":"doi:10.1001/archderm.105.5.761","doi":"https://doi.org/10.1001/archderm.105.5.761","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.105.5.761","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111470858","display_name":"David H. Huffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David H. Huffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520553","display_name":"Suk Han Wan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suk Han Wan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087571821","display_name":"Daniel L. Azarnoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel L. Azarnoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43600973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"5","first_page":"761","last_page":"761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-distribution","display_name":"drug distribution","score":0.7829999923706055},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fluorometric-assay","display_name":"fluorometric assay","score":0.7829999923706055},{"id":"https://openalex.org/keywords/sensitivity-bounds","display_name":"sensitivity limits","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8991074562072754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7985467910766602},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6502204537391663},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.6407265067100525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48355409502983093},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4413444995880127},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3512956500053406},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/archderm.105.5.761","doi":"https://doi.org/10.1001/archderm.105.5.761","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.105.5.761","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"To":[0],"the":[1,8,19,60,76,84,95,118,123,134],"Editor.\u2014":[2],"We":[3],"recently":[4],"became":[5],"aware":[6],"of":[7,21,52,79,90,102,143],"paper":[9],"by":[10,111],"Halprin":[11,112],"KW":[12],"et":[13,113],"al,":[14],"(Arch":[15],"Derm103:243-249,":[16],"1971),":[17],"wherein":[18],"pharmacokinetics":[20],"methotrexate":[22,36,64,80],"are":[23],"described.":[24],"They":[25],"observed":[26],"a":[27],"rather":[28,121],"short":[29,85],"half-life":[30,62,86,98,108],"(two":[31],"to":[32,57,104],"ten":[33],"hours)":[34],"for":[35,63],"following":[37],"both":[38],"oral":[39],"and":[40,94,125,137],"intramuscular":[41],"administration.":[42],"Based":[43],"upon":[44],"recent":[45],"studies":[46],"in":[47,65],"our":[48],"laboratory":[49],"with":[50,83],"use":[51],"tritium-labeled":[53],"methotrexate,":[54],"we":[55,131],"wish":[56],"report":[58],"that":[59,71,139],"plasma":[61,77,97],"man":[66],"is":[67,81,145],"considerably":[68],"longer":[69,124],"than":[70,122],"reported.":[72],"In":[73,129],"18":[74],"patients,":[75],"disappearance":[78],"biphasic":[82],"(representing":[87,99],"drug":[88,100],"distribution)":[89],"about":[91],"one-half":[92],"hour":[93],"long":[96],"elimination)":[101],"25":[103],"30":[105],"hours.":[106],"The":[107],"value":[109],"reported":[110],"al":[114],"most":[115],"likely":[116],"represents":[117],"distributive":[119],"phase":[120],"more":[126],"important":[127],"half-life.":[128],"addition,":[130],"have":[132],"examined":[133],"fluorometric":[135],"method":[136],"find":[138],"its":[140],"lower":[141],"limit":[142],"sensitivity":[144],"0.1\u03bcg/ml.":[146],"Since":[147],"it":[148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}