{"id":"https://openalex.org/W4247023658","doi":"https://doi.org/10.2307/3433522","title":"Asbestos and Silica-Induced Changes in Human Alveolar Macrophage Phenotype","display_name":"Asbestos and Silica-Induced Changes in Human Alveolar Macrophage Phenotype","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W4247023658","doi":"https://doi.org/10.2307/3433522"},"language":"en","primary_location":{"id":"doi:10.2307/3433522","doi":"https://doi.org/10.2307/3433522","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3433522","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2307/3433522","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105231873","display_name":"Andrij Holian","orcid":"https://orcid.org/0000-0003-0072-4538","observed_orcids":["https://orcid.org/0000-0003-0072-4538"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrij Holian","raw_affiliation_strings":["Departments of Internal Medicine and 2Pathology, University of Texas Houston Health Science Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and 2Pathology, University of Texas Houston Health Science Center, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024175094","display_name":"Margaret O. Uthman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret O. Uthman","raw_affiliation_strings":["MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082673583","display_name":"Tatiana Goltsova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Goltsova","raw_affiliation_strings":["MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407143","display_name":"Steven D. Brown","orcid":"https://orcid.org/0000-0002-9281-3898","observed_orcids":["https://orcid.org/0000-0002-9281-3898"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Brown","raw_affiliation_strings":["MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101867832","display_name":"Raymond F. Hamilton","orcid":"https://orcid.org/0000-0003-2862-3616","observed_orcids":["https://orcid.org/0000-0003-2862-3616"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond F. Hamilton","raw_affiliation_strings":["MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSB, Department of Internal Medicine. University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5105231873"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.3602,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70094019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"105","issue":null,"first_page":"1139","last_page":"1139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asbestos","display_name":"asbestos","score":0.984000027179718},{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.972000002861023},{"id":"https://openalex.org/keywords/macrophage-phenotype","display_name":"macrophage phenotype","score":0.9900000095367432},{"id":"https://openalex.org/keywords/particle-toxicity","display_name":"particle toxicity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C510490043","wikidata":"https://www.wikidata.org/wiki/Q104085","display_name":"Asbestos","level":2,"score":0.8719358444213867},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.680489718914032},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5826153755187988},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5489752888679504},{"id":"https://openalex.org/C2776762749","wikidata":"https://www.wikidata.org/wiki/Q664174","display_name":"Asbestosis","level":3,"score":0.5469035506248474},{"id":"https://openalex.org/C2987845665","wikidata":"https://www.wikidata.org/wiki/Q17072363","display_name":"Occupational exposure","level":2,"score":0.44819581508636475},{"id":"https://openalex.org/C2778543330","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Pulmonary alveolus","level":4,"score":0.427878737449646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3434963524341583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33882832527160645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3329673409461975},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.26577940583229065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14491963386535645},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13998353481292725},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10233333706855774},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0866841971874237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2307/3433522","doi":"https://doi.org/10.2307/3433522","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3433522","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2307/3433522","doi":"https://doi.org/10.2307/3433522","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3433522","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W136081727","https://openalex.org/W1655129990","https://openalex.org/W1900370339","https://openalex.org/W1968140100","https://openalex.org/W1991865867","https://openalex.org/W1999418834","https://openalex.org/W2059737835","https://openalex.org/W2069041849","https://openalex.org/W2075215508","https://openalex.org/W2120794083","https://openalex.org/W2134140400","https://openalex.org/W2141523423","https://openalex.org/W2244487778","https://openalex.org/W2252078410","https://openalex.org/W2274432633","https://openalex.org/W4234801656"],"related_works":["https://openalex.org/W7098620667","https://openalex.org/W2168381784","https://openalex.org/W641146917","https://openalex.org/W7097697980","https://openalex.org/W2347182773","https://openalex.org/W2078164401","https://openalex.org/W2320368351","https://openalex.org/W83559072","https://openalex.org/W2012319799","https://openalex.org/W1965419499"],"abstract_inverted_index":{"Andrij":[0],"Holian,":[1],"Margaret":[2],"O.":[3],"Uthman,":[4],"Tatiana":[5],"Goltsova,":[6],"Steven":[7],"D.":[8],"Brown,":[9],"Raymond":[10],"F.":[11],"Hamilton,":[12],"Jr.,":[13],"Asbestos":[14],"and":[15],"Silica-Induced":[16],"Changes":[17],"in":[18],"Human":[19],"Alveolar":[20],"Macrophage":[21],"Phenotype,":[22],"Environmental":[23],"Health":[24],"Perspectives,":[25],"Vol.":[26],"105,":[27],"Supplement":[28],"5:":[29],"Particle":[30],"Toxicity":[31],"(Sep.,":[32],"1997),":[33],"pp.":[34],"1139-1142":[35]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-05-12T00:00:00"}