{"id":"https://openalex.org/W4246991981","doi":"https://doi.org/10.1016/j.jalz.2009.04.1164","title":"P3\u2010088: Longitudinal study of amyloid deposition in carriers of presenilin\u20101, presenilin\u20102 and APP mutations","display_name":"P3\u2010088: Longitudinal study of amyloid deposition in carriers of presenilin\u20101, presenilin\u20102 and APP mutations","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W4246991981","doi":"https://doi.org/10.1016/j.jalz.2009.04.1164"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.1164","doi":"https://doi.org/10.1016/j.jalz.2009.04.1164","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.1164","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036841670","display_name":"William Edward Klunk","orcid":"https://orcid.org/0000-0001-5512-0251","observed_orcids":["https://orcid.org/0000-0001-5512-0251"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William E. Klunk","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E. Snitz","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024995302","display_name":"Ann D. Cohen","orcid":"https://orcid.org/0000-0001-7395-9624","observed_orcids":["https://orcid.org/0000-0001-7395-9624"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann D. Cohen","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758454","display_name":"Julie C. Price","orcid":"https://orcid.org/0000-0001-7131-4865","observed_orcids":["https://orcid.org/0000-0001-7131-4865"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie C. Price","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029440312","display_name":"Chester A. Mathis","orcid":"https://orcid.org/0000-0001-9811-0950","observed_orcids":["https://orcid.org/0000-0001-9811-0950"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester A. Mathis","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508217","display_name":"Howard Jay Aizenstein","orcid":"https://orcid.org/0000-0003-4897-6582","observed_orcids":["https://orcid.org/0000-0003-4897-6582"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Aizenstein","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088223178","display_name":"Judith A. Saxton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith A. Saxton","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084618289","display_name":"Steven Trent DeKosky","orcid":"https://orcid.org/0000-0003-3743-2758","observed_orcids":["https://orcid.org/0000-0003-3743-2758"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T. DeKosky","raw_affiliation_strings":["University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036841670"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51513968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4S_Part_12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/presenilin-1-mutations","display_name":"presenilin 1 mutations","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8323550224304199},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5637933611869812},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.549688994884491},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4834490716457367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47498172521591187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46503323316574097},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4554426968097687},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44334128499031067},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39642569422721863},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3484236001968384},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.27326634526252747},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21116366982460022}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.1164","doi":"https://doi.org/10.1016/j.jalz.2009.04.1164","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.1164","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085775550","https://openalex.org/W3021327035","https://openalex.org/W2000397440","https://openalex.org/W2108041327","https://openalex.org/W1972481932","https://openalex.org/W3021279525","https://openalex.org/W2581439514","https://openalex.org/W2131439915","https://openalex.org/W2334316422","https://openalex.org/W3179563852"],"abstract_inverted_index":{"Amyloid":[0],"imaging":[1],"with":[2,17,82,86,90,181,268,293],"PiB":[3,76,104,156,171,190,216,237,297],"PET":[4,105],"allows":[5],"longitudinal":[6],"studies":[7,77,146],"that":[8,19,194],"can":[9,32],"assess":[10],"natural":[11,49,310],"history":[12,50,311],"in":[13,35,54,63,139,173,195,215,236,239,253,274,315,342],"individual":[14],"subjects.":[15],"Subjects":[16,292],"mutations":[18,62,339],"cause":[20],"early-onset":[21],"familial":[22],"AD":[23,197],"(eFAD)":[24],"are":[25],"ideal":[26],"for":[27,122],"these":[28,232],"studies,":[29],"since":[30],"individuals":[31],"be":[33],"identified":[34],"the":[36,48,178,226,244,254,258,263,294,309,321,329],"pre-symptomatic":[37,55],"period":[38],"and":[39,56,67,88,107,119,134,204,225,285,332],"followed":[40],"over":[41,78,218,302],"time.":[42,303],"Our":[43],"objective":[44],"was":[45],"to":[46,99,110,136,193,290,307,349],"follow":[47],"of":[51,59,189,231,257,282,312,323,345],"amyloid":[52,313,324,346],"deposition":[53,314,325,347],"symptomatic":[57],"carriers":[58,71,167,261],"autosomal":[60],"dominant":[61],"presenilin-1":[64],"(PS1),":[65],"PS2":[66,92,224],"APP.":[68],"Thirteen":[69],"mutation":[70,265],"(28-56":[72],"years)":[73],"received":[74],"follow-up":[75],"12-24":[79,219],"months":[80,220],"(nine":[81],"PS1":[83],"mutations,":[84],"three":[85],"APP":[87],"one":[89],"a":[91,279,300,343],"mutation).":[93],"Clinical":[94],"diagnosis":[95],"varied":[96],"from":[97,115],"normal":[98],"AD.":[100,351],"All":[101],"subjects":[102,142,152,180,211,317],"underwent":[103],"scanning":[106],"tissue":[108],"ratios":[109],"cerebellum":[111],"(SUVR)":[112],"were":[113,120,132],"calculated":[114,133],"40-60":[116],"min":[117],"post-injection":[118],"corrected":[121],"atrophy":[123],"using":[124],"co-registered":[125],"MRIs.":[126],"Regional":[127],"delta-SUVR":[128],"values":[129],"between":[130],"scans":[131],"compared":[135],"changes":[137],"measured":[138],"22":[140],"other":[141],"who":[143],"had":[144,153],"test-retest":[145],"performed":[147],"within":[148],"28":[149],"days.":[150],"Eleven":[151],"high":[154],"striatal":[155,182,296],"retention":[157,172,191,217,238,298],"at":[158],"baseline;":[159],"two":[160],"young":[161],"(28":[162],"&":[163,206],"36":[164,245],"y/o)":[165],"APP-V717I":[166],"showed":[168,186,212,234,249,271,299],"no":[169],"specific":[170,330],"any":[174,275],"brain":[175,241,276],"region.":[176],"Of":[177],"11":[179],"retention,":[183],"only":[184,252],"four":[185],"neocortical":[187],"patterns":[188],"similar":[192,348],"late-onset":[196,350],"(56":[198],"y/o":[199,202,208,228,246],"APP-V717I,":[200],"55":[201],"PS2-N141I":[203],"31":[205,227],"44":[207],"PS1-M233L).":[209,229],"Five":[210],"significant":[213],"increases":[214,235],"(3-of-3":[221],"APP,":[222],"1-of-1":[223],"Four":[230],"five":[233],"many":[240],"areas,":[242],"but":[243],"PS1-V717I":[247],"carrier":[248,266],"an":[250,272],"increase":[251,273],"striatum.":[255],"None":[256],"six":[259],"PS1-A426P":[260],"or":[262],"PS1-C410Y":[264],"(all":[267],"striatal-predominant":[269],"deposition)":[270],"region":[277],"despite":[278],"wide":[280],"range":[281],"age":[283],"(37-51)":[284],"clinical":[286],"status":[287],"(normal":[288],"cognition":[289],"AD).":[291],"highest":[295],"decrease":[301],"It":[304],"is":[305,326,334],"possible":[306],"track":[308],"living":[316],"longitudinally.":[318],"In":[319],"eFAD,":[320],"course":[322],"dependent":[327],"on":[328],"mutation,":[331],"it":[333],"not":[335],"clear":[336],"whether":[337],"all":[338],"will":[340],"result":[341],"pattern":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}