{"id":"https://openalex.org/W4246970353","doi":"https://doi.org/10.1149/ma2019-02/52/2273","title":"Superparamagnetic Fe3O4-Au Core-Shell Nanoplasmonic Sensing Array for Label-Free Multiplex Cytokine Detection","display_name":"Superparamagnetic Fe3O4-Au Core-Shell Nanoplasmonic Sensing Array for Label-Free Multiplex Cytokine Detection","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W4246970353","doi":"https://doi.org/10.1149/ma2019-02/52/2273"},"language":"en","primary_location":{"id":"doi:10.1149/ma2019-02/52/2273","doi":"https://doi.org/10.1149/ma2019-02/52/2273","is_oa":false,"landing_page_url":"https://doi.org/10.1149/ma2019-02/52/2273","pdf_url":null,"source":{"id":"https://openalex.org/S4210168594","display_name":"ECS Meeting Abstracts","issn_l":"1091-8213","issn":["1091-8213","2151-2035","2151-2043","2152-8365"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311669","host_organization_name":"Institute of Physics","host_organization_lineage":["https://openalex.org/P4310311669"],"host_organization_lineage_names":["Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ECS Meeting Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101857753","display_name":"Yuxin Cai","orcid":"https://orcid.org/0000-0001-7459-5375","observed_orcids":["https://orcid.org/0000-0001-7459-5375","https://orcid.org/0009-0003-4678-2124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuxin Cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698986","display_name":"Jingyi Zhu","orcid":"https://orcid.org/0009-0007-8771-9593","observed_orcids":["https://orcid.org/0009-0007-8771-9593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingyi Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399928","display_name":"Jiacheng He","orcid":"https://orcid.org/0000-0002-1940-4262","observed_orcids":["https://orcid.org/0000-0002-1940-4262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiacheng He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1940-4262","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024721204","display_name":"Wen Yang","orcid":"https://orcid.org/0000-0001-9206-0868","observed_orcids":["https://orcid.org/0000-0001-9206-0868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030010348","display_name":"Chao Ma","orcid":"https://orcid.org/0000-0001-7741-818X","observed_orcids":["https://orcid.org/0000-0001-7741-818X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448808","display_name":"Feng Li","orcid":"https://orcid.org/0000-0001-5236-3709","observed_orcids":["https://orcid.org/0000-0001-5236-3709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739315","display_name":"Weiqiang Chen","orcid":"https://orcid.org/0000-0002-9469-8328","observed_orcids":["https://orcid.org/0000-0002-9469-8328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiqiang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100317518","display_name":"Pengyu Chen","orcid":"https://orcid.org/0000-0003-3380-872X","observed_orcids":["https://orcid.org/0000-0003-3380-872X","https://orcid.org/0009-0005-4035-6989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengyu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"MA2019-02","issue":"52","first_page":"2273","last_page":"2273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10295","display_name":"Plasmonic and Surface Plasmon Research","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fe3o4-au-core-shell-nanoparticles","display_name":"Fe3O4@Au core-shell nanoparticles","score":0.8809999823570251},{"id":"https://openalex.org/keywords/localized-surface-plasmon-resonance","display_name":"localized surface plasmon resonance","score":0.8700000047683716},{"id":"https://openalex.org/keywords/label-free-optical-biosensing","display_name":"label-free optical biosensing","score":0.9309999942779541},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.8960000276565552},{"id":"https://openalex.org/keywords/microfluidic-biosensor","display_name":"microfluidic biosensor","score":0.5040000081062317},{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.3370000123977661},{"id":"https://openalex.org/keywords/au-nanorods","display_name":"Au nanorods","score":0.4830000102519989},{"id":"https://openalex.org/keywords/antibody-immobilization","display_name":"antibody immobilization","score":0.4749999940395355},{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.7601523399353027},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7310064435005188},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6947981119155884},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6775840520858765},{"id":"https://openalex.org/C57528182","wikidata":"https://www.wikidata.org/wiki/Q1271842","display_name":"Miniaturization","level":2,"score":0.5936294794082642},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5842422246932983},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.5016372203826904},{"id":"https://openalex.org/C126201875","wikidata":"https://www.wikidata.org/wiki/Q2684948","display_name":"Nanorod","level":2,"score":0.44473692774772644},{"id":"https://openalex.org/C20788544","wikidata":"https://www.wikidata.org/wiki/Q467054","display_name":"Photonics","level":2,"score":0.43009430170059204},{"id":"https://openalex.org/C110879396","wikidata":"https://www.wikidata.org/wiki/Q58392","display_name":"Plasmon","level":2,"score":0.4267946779727936},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.38294631242752075},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3406860828399658},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.16104930639266968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1149/ma2019-02/52/2273","doi":"https://doi.org/10.1149/ma2019-02/52/2273","is_oa":false,"landing_page_url":"https://doi.org/10.1149/ma2019-02/52/2273","pdf_url":null,"source":{"id":"https://openalex.org/S4210168594","display_name":"ECS Meeting Abstracts","issn_l":"1091-8213","issn":["1091-8213","2151-2035","2151-2043","2152-8365"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311669","host_organization_name":"Institute of Physics","host_organization_lineage":["https://openalex.org/P4310311669"],"host_organization_lineage_names":["Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ECS Meeting Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134672431","https://openalex.org/W2910180595","https://openalex.org/W2159188461","https://openalex.org/W2564509443","https://openalex.org/W2612413763","https://openalex.org/W3024823333","https://openalex.org/W4387771493","https://openalex.org/W2595426620","https://openalex.org/W7097425550","https://openalex.org/W2969080454"],"abstract_inverted_index":{"The":[0,34,75,89,231,248,341,557,594,684,701],"ongoing":[1],"revolution":[2],"in":[3,31,70,152,202,237,291,317,323,334,442,731],"fundamental":[4],"biology":[5],"and":[6,45,92,106,175,204,210,228,245,264,280,293,302,376,389,425,597,608,628,644],"clinical":[7,79,279],"discovery":[8],"critically":[9],"hinges":[10],"on":[11,84,181,337,455,513,545,661,698],"the":[12,28,32,63,127,136,144,177,182,208,272,289,298,313,349,352,418,436,470,475,502,508,514,520,536,560,600,626,632,638,666,671,699,725],"availability":[13],"of":[14,18,36,49,68,110,129,155,163,188,197,212,250,274,327,343,351,361,474,543,559,574,581,590,599,613,620,631,641,676,695,714,717,728],"diagnostic":[15],"tools":[16],"capable":[17],"decentralized":[19],"point-of-care":[20],"measurements":[21],"to":[22,60,101,288,312,519,583,655],"provide":[23],"immediate":[24],"quantitative":[25],"information":[26],"at":[27,126,141,409],"bedside":[29],"or":[30],"clinic.":[33],"case":[35],"immune":[37,66,124],"monitoring":[38,125],"for":[39,123,146,267,277,355,393,462,489,549,617],"practical":[40,268,615],"medical":[41,443],"treatment,":[42],"fast,":[43],"accurate":[44],"high":[46,242,737],"throughput":[47,243,292,350,424],"analysis":[48,154],"multiple":[50,328,575],"cytokines":[51,548,576,730],"using":[52,367,587,680],"a":[53,96,107,338,400,410,448,456,498,565,578,650,662,674,692,732],"small":[54],"sample":[55,108,551],"volume":[56,109],"is":[57,81],"highly":[58,254],"required":[59],"precisely":[61],"determine":[62],"rapidly":[64],"changing":[65],"status":[67],"patients":[69],"different":[71,547],"inflammatory":[72],"disease":[73],"conditions.":[74],"current":[76],"\u201cgold":[77],"standard\u201d":[78],"technology":[80,315,437],"mainly":[82],"based":[83,180,454],"Enzyme-linked":[85],"immunosorbent":[86],"assay":[87,98],"(ELISA).":[88],"complex":[90,156],"labelling":[91],"washing":[93],"processes":[94],"require":[95,382],"total":[97],"time":[99],"up":[100],"more":[102],"than":[103],"72":[104],"hours":[105],"0.5-":[111],"2":[112],"mL":[113,589],"per":[114,116,555],"test":[115,544],"patient,":[117],"which":[118,380],"greatly":[119],"hinders":[120],"its":[121,614],"application":[122],"point":[128],"care.":[130],"Label-free":[131],"optical":[132,137,166],"biosensing":[133,179],"platforms,":[134],"where":[135],"responses":[138],"are":[139,309,390,399,427,602],"measured":[140],"real-time":[142],"without":[143,295],"need":[145],"secondary":[147],"labelling,":[148],"offer":[149,234],"unique":[150,471],"advantages":[151],"rapid":[153,314],"biological":[157,261,592],"samples.":[158,593],"Among":[159],"these":[160,251,362],"techniques,":[161],"inclusive":[162],"photonic":[164],"crystal,":[165],"ring":[167],"resonator,":[168],"surface":[169,184,486],"plasmon":[170,185],"resonance":[171,186],"(SPR),":[172],"fiber":[173],"optics":[174],"interferometry,":[176],"nanoplasmonic":[178,215,232,306,353,404],"localized":[183],"(LSPR)":[187],"noble":[189],"metal":[190],"nanoparticles":[191,465,511,643],"(NPs)":[192],"has":[193,258,283,346,414],"shown":[194],"exquisite":[195],"levels":[196],"sensing":[198,307,363,405,422,495,709],"performance.":[199],"Recent":[200],"advances":[201],"nanomaterials":[203],"nanotechnology":[205],"have":[206],"spurred":[207],"design":[209],"fabrication":[211,387,460],"next":[213],"generation":[214],"biosensors":[216,354,539],"with":[217,552,577,673,711,736],"various":[218],"nanostructures,":[219],"such":[220,275],"as":[221],"nanorod,":[222],"nano-bipyramid,":[223],"nano-flower,":[224],"nano":[225],"core-shell":[226,464],"structure":[227],"nanohole":[229],"arrays.":[230],"structures":[233],"remarkable":[235],"potential":[236],"sensor":[238],"sensitivity,":[239,300],"tunability,":[240],"miniaturization,":[241],"capability,":[244],"large-scale":[246],"fabrication.":[247],"integration":[249,558],"platforms":[252,308,406],"into":[253,564],"functional":[255,618],"microfluidic":[256,682],"devices":[257,276],"provided":[259],"novel":[260],"interfacing":[262],"opportunities":[263],"promising":[265],"features":[266],"biomarker":[269],"detection.":[270],"However,":[271],"implementation":[273],"real":[278,591],"pharmaceutical":[281],"settings":[282],"still":[284],"been":[285],"prohibited":[286],"due":[287],"deficiency":[290],"manufacturability":[294],"necessarily":[296],"compromising":[297],"desirable":[299],"multiplicity":[301],"reliability.":[303],"Various":[304],"microarray":[305,538,562,660,667,718],"flourishing":[310],"owing":[311],"evolution":[316],"nanofabrication.":[318],"They":[319],"hold":[320],"great":[321],"promise":[322],"massively":[324,571,733],"parallel":[325,344,572,681,734],"quantification":[326],"analytes":[329],"by":[330,507,605],"immobilizing":[331],"specific":[332,721],"antibodies":[333,679],"separate":[335],"spots":[336,496],"single":[339],"array.":[340],"versatility":[342],"detection":[345,573,582,727],"significantly":[347],"increased":[348],"multiplex":[356,451,726],"label-free":[357],"analysis.":[358],"Yet,":[359],"majority":[360],"arrays":[364],"were":[365,687],"fabricated":[366],"electron":[368],"beam":[369],"lithography,":[370],"direct":[371],"laser":[372],"writing,":[373],"chemical":[374,629],"electrodeposition":[375],"dip":[377],"pen":[378],"nanolithography,":[379],"often":[381],"dedicated":[383],"instrumentations,":[384],"labor":[385],"intensive":[386],"procedures":[388],"extremely":[391],"costly":[392],"large":[394,499,715],"scale":[395],"production.":[396],"While":[397],"there":[398],"few":[401],"multi-analyte":[402],"high-throughput":[403],"being":[407],"developed":[408,447,531],"fast":[411],"pace,":[412],"it":[413],"become":[415],"clear":[416],"that":[417,431,634],"cost,":[419],"operation":[420],"complexity,":[421],"performance,":[423],"scalability":[426],"equally":[428],"challenging":[429],"issues":[430],"must":[432],"be":[433,439],"addressed":[434],"before":[435],"can":[438,540],"widely":[440],"accepted":[441],"practice.":[444],"Here,":[445],"we":[446,480,648,669],"high-throughput,":[449],"label-free,":[450],"LSPR":[452,532],"immunoassay":[453,601],"facile":[457],"magnet":[458,651],"assisted":[459,652],"method":[461],"Fe3O4/Au":[463],"(FACSNPs)":[466],"microarrays.":[467],"By":[468],"harnessing":[469],"superparamagnetic":[472],"property":[473],"hollow":[476],"iron":[477],"oxide":[478],"nanocore,":[479],"demonstrated":[481],"an":[482],"easy-to-implement,":[483],"scalable":[484],"nanoparticle":[485],"patterning":[487],"technique":[488],"generating":[490],"regular-shape,":[491],"well":[492],"dispersed,":[493],"individual":[494],"over":[497],"area.":[500],"Moreover,":[501],"strong":[503],"plasmonic":[504],"coupling":[505],"afforded":[506],"decorated":[509],"gold":[510],"(AuNPs)":[512],"FACSNPs":[515,537,561,633,672,686],"exhibit":[516],"superior":[517],"sensitivity":[518],"local":[521],"refractive":[522],"index":[523],"change":[524],"upon":[525],"cytokine":[526,678],"binding.":[527],"Incorporating":[528],"our":[529],"previous":[530],"dark-field":[533],"imaging":[534],"technique,":[535],"conduct":[541],"384":[542],"four":[546,677,706,729],"each":[550,712],"16":[553],"replicates":[554],"cytokine-test.":[556],"sensors":[563,719],"simple":[566],"optofluidic":[567],"device":[568],"allows":[569],"real-time,":[570],"low":[579],"limit":[580],"~":[584],"20":[585],"pg/mL":[586],"1":[588,741],"stability,":[595],"accuracy":[596],"reproducibility":[598],"further":[603],"confirmed":[604],"standard":[606],"ELISA":[607],"validated":[609],"through":[610],"successful":[611,702],"demonstration":[612],"use":[616],"immunophenotyping":[619],"tumor-associated":[621],"macrophage":[622],"(TAM)":[623],"differentiation.":[624],"Using":[625],"physical":[627],"properties":[630,640],"arise":[635],"from":[636],"both":[637],"intrinsic":[639],"constituent":[642],"their":[645],"interparticle":[646],"interactions,":[647],"adopted":[649],"self-assembly":[653],"process":[654],"pattern":[656],"uniform":[657],"antibody":[658,696,703],"functioned":[659,685],"glass":[663],"substrate.":[664],"Following":[665],"patterning,":[668],"functionalized":[670],"panel":[675],"channels.":[683],"imaged":[688],"under":[689],"SEM":[690],"showing":[691],"thick":[693],"layer":[694],"coating":[697],"NPs.":[700],"function":[704],"yielded":[705],"physically":[707],"separated":[708],"regions":[710],"consisting":[713],"numbers":[716],"targeting":[720],"cytokines.":[722],"This":[723],"permits":[724],"manner":[735],"statistic":[738],"accuracy.":[739],"Figure":[740]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-05-12T00:00:00"}