{"id":"https://openalex.org/W4246577974","doi":"https://doi.org/10.2174/1570180811209050953","title":"Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine- 5-carboxamide Derivatives by Using One-pot Multicomponent Method","display_name":"Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine- 5-carboxamide Derivatives by Using One-pot Multicomponent Method","publication_year":2012,"publication_date":"2012-10-24","ids":{"openalex":"https://openalex.org/W4246577974","doi":"https://doi.org/10.2174/1570180811209050953"},"language":"en","primary_location":{"id":"doi:10.2174/1570180811209050953","doi":"https://doi.org/10.2174/1570180811209050953","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180811209050953","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043428970","display_name":"Abdulrahman Ibrahim Almansour","orcid":"https://orcid.org/0000-0002-8636-6366","observed_orcids":["https://orcid.org/0000-0002-8636-6366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdulrahman I. Almansour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685437","display_name":"Mohamed Ashraf Ali","orcid":"https://orcid.org/0000-0003-2352-2760","observed_orcids":["https://orcid.org/0000-0003-2352-2760"]},"institutions":[{"id":"https://openalex.org/I4405277920","display_name":"Institute of Engineering & Technology","ror":"https://ror.org/04aymkn24","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405277920"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mohamed Ashraf Ali","raw_affiliation_strings":["Centre IET Group of Institutions, M.I.A North Extension, Alwar, Rajastan - 301030, India.,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre IET Group of Institutions, M.I.A North Extension, Alwar, Rajastan - 301030, India.,India","institution_ids":["https://openalex.org/I4405277920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017570637","display_name":"Sadath Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277920","display_name":"Institute of Engineering & Technology","ror":"https://ror.org/04aymkn24","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405277920"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sadath Ali","raw_affiliation_strings":["Centre IET Group of Institutions, M.I.A North Extension, Alwar, Rajastan - 301030, India.,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre IET Group of Institutions, M.I.A North Extension, Alwar, Rajastan - 301030, India.,India","institution_ids":["https://openalex.org/I4405277920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051346695","display_name":"Ang Chee Wei","orcid":"https://orcid.org/0000-0002-4512-2592","observed_orcids":["https://orcid.org/0000-0002-4512-2592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ang Chee Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yeong Keng Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeong Keng Yoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100562384","display_name":"Rusli Ismail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rusli Ismail","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108588482","display_name":"Tan Soo Choon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tan Soo Choon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091683387","display_name":"Suresh Pandian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Pandian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066865002","display_name":"Raju Suresh Kumar","orcid":"https://orcid.org/0000-0003-3754-4223","observed_orcids":["https://orcid.org/0000-0003-3754-4223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raju Suresh Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024215046","display_name":"Natarajan Arumugam","orcid":"https://orcid.org/0000-0001-9073-155X","observed_orcids":["https://orcid.org/0000-0001-9073-155X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natarajan Arumugam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051256126","display_name":"Hasnah Osman","orcid":"https://orcid.org/0000-0001-8695-470X","observed_orcids":["https://orcid.org/0000-0001-8695-470X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hasnah Osman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017570637","https://openalex.org/A5100685437"],"corresponding_institution_ids":["https://openalex.org/I4405277920"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"10","first_page":"953","last_page":"957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.2775999903678894,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimycobacterial-agents","display_name":"antimycobacterial agents","score":0.996999979019165},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/isoniazid-resistance","display_name":"isoniazid resistance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tetrahydropyrimidine-derivatives","display_name":"tetrahydropyrimidine derivatives","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pyridine-carboxamides","display_name":"pyridine carboxamides","score":0.6800000071525574},{"id":"https://openalex.org/keywords/biginelli-reaction","display_name":"Biginelli reaction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/one-pot-multicomponent-reaction","display_name":"one-pot multicomponent reaction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nitroimidazoles","display_name":"nitroimidazoles","score":0.8510000109672546},{"id":"https://openalex.org/keywords/electron-withdrawing-substituents","display_name":"electron-withdrawing substituents","score":0.8240000009536743},{"id":"https://openalex.org/keywords/antitubercular-activity","display_name":"antitubercular activity","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.9768975377082825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8533742427825928},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.7698882818222046},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7361474633216858},{"id":"https://openalex.org/C2778327999","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Carboxamide","level":2,"score":0.5550358295440674},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5133149027824402},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4730830788612366},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4491894841194153},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.4455476701259613},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3676936626434326},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.318560928106308},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.2381722331047058},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17117643356323242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.04711472988128662},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/1570180811209050953","doi":"https://doi.org/10.2174/1570180811209050953","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570180811209050953","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"},{"id":"doi:10.2174/157018012804586879","doi":"https://doi.org/10.2174/157018012804586879","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157018012804586879","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104749352","https://openalex.org/W2021823985","https://openalex.org/W803000272","https://openalex.org/W2197937183","https://openalex.org/W2058921637","https://openalex.org/W1989209567","https://openalex.org/W7171306212","https://openalex.org/W4410160769","https://openalex.org/W3133029570","https://openalex.org/W7171331543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}