{"id":"https://openalex.org/W4246533764","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c","title":"Abstract 1130: Role Of PI3K\u03b3 For Integrin-dependent Adhesive And Migratory Functions Of Progenitor Cells In Vitro And In Vivo","display_name":"Abstract 1130: Role Of PI3K\u03b3 For Integrin-dependent Adhesive And Migratory Functions Of Progenitor Cells In Vitro And In Vivo","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W4246533764","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c"},"language":"en","primary_location":{"id":"doi:10.1161/circ.116.suppl_16.ii_227-c","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022309505","display_name":"Emmanouil Chavakis","orcid":"https://orcid.org/0000-0002-2821-7397","observed_orcids":["https://orcid.org/0000-0002-2821-7397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanouil Chavakis","raw_affiliation_strings":["Molecular Cardiology, Frankfurt A. M., Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, Frankfurt A. M., Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104064348","display_name":"Guillaume Carmona","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guillaume Carmona","raw_affiliation_strings":["Molecular Cardiology, Frankfurt A. M., Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, Frankfurt A. M., Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086672334","display_name":"Triantafyllos Chavakis","orcid":"https://orcid.org/0000-0002-1869-5141","observed_orcids":["https://orcid.org/0000-0002-1869-5141"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Triantafyllos Chavakis","raw_affiliation_strings":["National Cancer Institute / NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute / NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061907666","display_name":"Andreas Michael Zeiher","orcid":"https://orcid.org/0000-0003-1711-5819","observed_orcids":["https://orcid.org/0000-0003-1711-5819"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas M Zeiher","raw_affiliation_strings":["Dept of Internal Medicine, Univ Frankfurt, Frankfurt A. M., Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Internal Medicine, Univ Frankfurt, Frankfurt A. M., Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025706940","display_name":"Stefanie Dimmeler","orcid":"https://orcid.org/0000-0002-1045-2436","observed_orcids":["https://orcid.org/0000-0002-1045-2436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie Dimmeler","raw_affiliation_strings":["Molecular Cardiology, Frankfurt A. M., Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology, Frankfurt A. M., Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"suppl_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3kgamma","display_name":"PI3K\u03b3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/integrin-mediated-cell-adhesion","display_name":"integrin-mediated adhesion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.7829999923706055},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/transendothelial-migration","display_name":"transendothelial migration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.7795405387878418},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.643923819065094},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6389593482017517},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6158117055892944},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6109776496887207},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.5108113288879395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3481712341308594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2941957712173462},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.29402393102645874},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22108778357505798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08751294016838074},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.116.suppl_16.ii_227-c","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_227-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066252427","https://openalex.org/W2088816549","https://openalex.org/W2129718198","https://openalex.org/W2117235345","https://openalex.org/W2345807090","https://openalex.org/W206918882","https://openalex.org/W4254027282","https://openalex.org/W2013613825","https://openalex.org/W7019831982","https://openalex.org/W3012641522"],"abstract_inverted_index":{"Endothelial":[0],"progenitor":[1,20,71,228,261,302,316],"cells":[2,229,262,280,303],"(EPC)":[3],"are":[4,34],"recruited":[5],"to":[6,9,23,40,130,242,251,263,278,330],"ischemic":[7,24,41,131,264,340],"regions":[8],"improve":[10,331],"neovascularization.":[11],"\u03b21-":[12],"and":[13,27,109,113,153,217,306],"\u03b22-integrins":[14],"play":[15],"a":[16,97,123,156,172,252],"crucial":[17],"role":[18,63,88,296],"for":[19,66,91,297,321],"cell":[21,317],"homing":[22,39,68,129,256,300,318],"tissues.":[25,42,132],"Chemokines":[26],"their":[28],"respective":[29],"G-protein":[30],"coupled":[31],"receptors":[32],"(GPCRs)":[33],"involved":[35,181],"in":[36,178,182,210,240,269,276,304,307,328,337],"the":[37,50,62,80,87,107,110,114,136,140,160,165,183,201,214,270,298,312,322,332],"EPC":[38,78,92,128,144,169,179],"The":[43,309],"phosphatidylinositol-3-kinase":[44],"catalytic":[45,81],"subunit":[46,82],"gamma":[47],"(PI3K\u03b3)":[48],"is":[49,122,180,319],"PI3K":[51],"isoform,":[52],"which":[53],"selectively":[54],"transduces":[55],"signals":[56],"from":[57,230],"GPCRs.":[58],"Here,":[59],"we":[60],"investigated":[61],"of":[64,70,89,118,143,168,185,189,204,208,221,255,257,272,301,311,315,324,334],"PI3K\u03b3":[65,90,177,199,292],"integrin-dependent":[67,299],"functions":[69],"cells.":[72,246],"As":[73],"assessed":[74],"by":[75,148],"western":[76],"blot,":[77],"express":[79],"PI3K\u03b3.":[83],"We":[84],"then":[85],"studied":[86],"migration.":[93],"AS-605240":[94],"(100":[95],"nM),":[96],"selective":[98],"PI3K\u03b3-inhibitor":[99,137,161],"(Camps":[100],"M,":[101],"Nat.":[102],"Med.,":[103],"2005),":[104],"significantly":[105,138],"reduced":[106,139,239],"SDF1-":[108],"IL-8-induced":[111],"migration":[112,117,216],"SDF1-induced":[115,141,166,202,215],"transendothelial":[116],"human":[119],"EPC.":[120,211],"Adhesion":[121],"further":[124],"essential":[125,295,320],"step":[126],"during":[127],"In":[133,193,247,286],"this":[134],"regard,":[135],"adhesion":[142,167,218],"on":[145,154,170,219],"HUVEC":[146],"monolayers":[147],"69":[149],"\u00b1":[150,282],"8":[151,283],"%":[152,284],"ICAM-1,":[155],"\u03b22-integrin":[157],"ligand.":[158],"However,":[159],"did":[162],"not":[163,188,207],"affect":[164],"fibronectin,":[171],"\u03b21-integrin":[173],"ligand,":[174],"suggesting":[175],"that":[176,291],"regulation":[184],"\u03b22-,":[186,205],"but":[187,206],"\u03b2":[190],"1-integrin-dependent":[191],"adhesion.":[192],"line":[194],"with":[195,339],"these":[196,288],"results,":[197],"inhibition":[198],"blocked":[200],"increase":[203],"\u03b21-integrin-affinity":[209],"Beside":[212],"EPC,":[213],"ICAM-1":[220],"murine":[222,258],"bone":[223],"marrow":[224],"(BM)-derived":[225],"Lin":[226],"\u2212":[227,234,236,260],"PI3K\u03b3-deficient":[231],"mice":[232],"(PI3K\u03b3":[233],"/":[235],")":[237],"were":[238],"comparison":[241,277],"wild":[243],"type":[244],"(WT)":[245],"addition,":[248],"PI3K\u03b3-deficiency":[249],"led":[250],"significant":[253],"reduction":[254],"BM-Lin":[259],"muscles":[265],"after":[266],"intravenous":[267],"infusion":[268],"model":[271],"hind":[273],"limb":[274],"ischemia":[275],"WT":[279],"(48":[281],"inhibition).":[285],"conclusion,":[287],"data":[289],"demonstrate":[290],"plays":[293],"an":[294],"vitro":[305],"vivo.":[308],"understanding":[310],"molecular":[313],"mechanisms":[314],"development":[323],"new":[325],"therapeutic":[326],"strategies":[327],"order":[329],"efficacy":[333],"cell-based":[335],"therapies":[336],"patients":[338],"disorders.":[341]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-12T00:00:00"}