{"id":"https://openalex.org/W4246096995","doi":"https://doi.org/10.21236/ada428460","title":"Signaling Pathways Controlling the Growth and Proliferation of Drosophila Perineurial Glial Cells","display_name":"Signaling Pathways Controlling the Growth and Proliferation of Drosophila Perineurial Glial Cells","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W4246096995","doi":"https://doi.org/10.21236/ada428460"},"language":"en","primary_location":{"id":"doi:10.21236/ada428460","doi":"https://doi.org/10.21236/ada428460","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada428460","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a428460.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a428460.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Stern","raw_affiliation_strings":[". PERFORMING ORGANIZATION NAME(S) AND ADDRESSES) Rice University-Houston, Texas 77251-1892","U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". PERFORMING ORGANIZATION NAME(S) AND ADDRESSES) Rice University-Houston, Texas 77251-1892","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012","institution_ids":["https://openalex.org/I2802581893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802581893","https://openalex.org/I74775410"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.671999990940094},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.9330000281333923},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glial-development","display_name":"glial development","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6634488105773926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5203730463981628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3643430471420288},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3329777121543884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19374379515647888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11701098084449768}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada428460","doi":"https://doi.org/10.21236/ada428460","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada428460","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a428460.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA428460","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA428460","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21236/ada428460","doi":"https://doi.org/10.21236/ada428460","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada428460","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a428460.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4246096995.pdf","grobid_xml":"https://content.openalex.org/works/W4246096995.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108511563","https://openalex.org/W2594953425","https://openalex.org/W2108392089","https://openalex.org/W4231387673","https://openalex.org/W7135746158","https://openalex.org/W4254596323","https://openalex.org/W2073913921","https://openalex.org/W87350350","https://openalex.org/W7027298757","https://openalex.org/W2794178202"],"abstract_inverted_index":{"The":[0,44,190],"long":[1],"term":[2],"goals":[3],"of":[4,32,46,53,66,79,98,104,106,128,160,168,180],"this":[5,47,169],"research":[6],"are":[7,38,188,201],"to":[8,70,176],"understand":[9],"the":[10,18,99,121,158,166,178],"mechanisms":[11],"by":[12,133],"which":[13],"NFl":[14],"controls":[15],"growth":[16,54,95,103,187],"using":[17],"Drosophila":[19],"peripheral":[20],"nerve.":[21],"This":[22],"system":[23],"is":[24,125],"advantageous":[25],"because":[26],"we":[27,60,140],"can":[28,152],"apply":[29],"a":[30,67,92,129],"number":[31],"powerful":[33],"molecular":[34],"genetic":[35],"methodologies":[36],"that":[37,77,123],"not":[39],"available":[40],"in":[41,112],"other":[42],"systems.":[43],"aims":[45],"project":[48],"address":[49],"three":[50],"specific":[51],"aspects":[52],"control.":[55],"In":[56],"our":[57,145,161],"first":[58],"aim,":[59,147],"asked":[61],"if":[62],"NF1":[63,80],"acts":[64],"downstream":[65],"G":[68],"protein":[69],"exert":[71],"its":[72,82],"effects.":[73],"We":[74],"have":[75],"found":[76],"overexpression":[78],"and":[81,87,172,197],"upstream":[83],"activators":[84],"amnesiac":[85],"(amn)":[86],"G(sub":[88,136],"a)s,":[89,137],"each":[90],"confer":[91],"similar":[93],"glial":[94,102,186],"phenotype:":[96],"enhancement":[97],"effects":[100,179],"on":[101,157,184],"expression":[105],"Ras(exp":[107],"V12),":[108],"but":[109,148],"no":[110,198],"effect":[111],"an":[113,126],"otherwise":[114],"wildtype":[115],"background.":[116],"These":[117],"data":[118],"strongly":[119],"support":[120],"hypothesis":[122],"Neurofibromin":[124],"effector":[127],"signalling":[130],"pathway":[131],"acting":[132],"amn":[134],"through":[135],"Last":[138],"year,":[139],"reported":[141],"negative":[142,150],"results":[143,151,200],"for":[144],"second":[146],"these":[149],"now":[153],"be":[154],"reinterpreted":[155],"based":[156],"success":[159],"newly":[162],"revised":[163],"hypothesis.":[164],"Under":[165],"aegis":[167],"hypothesis,":[170],"new":[171,199],"more":[173],"productive":[174],"experiments":[175],"test":[177],"altered":[181],"neurotransmitter":[182],"release":[183],"perineurial":[185],"proposed.":[189],"third":[191],"aim":[192],"was":[193],"completed":[194],"last":[195],"year":[196],"presented.":[202]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2022-05-12T00:00:00"}