{"id":"https://openalex.org/W4246062053","doi":"https://doi.org/10.1016/s0378-5173(01)00869-9","title":"Topical delivery of 5-fluorouracil (5-FU) by 1,3-bisalkylcarbonyl-5-FU prodrugs","display_name":"Topical delivery of 5-fluorouracil (5-FU) by 1,3-bisalkylcarbonyl-5-FU prodrugs","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W4246062053","doi":"https://doi.org/10.1016/s0378-5173(01)00869-9"},"language":"en","primary_location":{"id":"doi:10.1016/s0378-5173(01)00869-9","doi":"https://doi.org/10.1016/s0378-5173(01)00869-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-5173(01)00869-9","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064269569","display_name":"Howard D. Beall","orcid":"https://orcid.org/0000-0001-8601-1496","observed_orcids":["https://orcid.org/0000-0001-8601-1496"]},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard D Beall","raw_affiliation_strings":["Department of Pharmaceutical Sciences, The University of Montana, 32 Campus Drive No. 1552, Missoula, MT 59812-1552, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, The University of Montana, 32 Campus Drive No. 1552, Missoula, MT 59812-1552, USA","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112449017","display_name":"Kenneth B. Sloan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth B Sloan","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112449017"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.0533,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70233247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"231","issue":"1","first_page":"43","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9919999837875366},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.8519999980926514},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.9369999766349792},{"id":"https://openalex.org/keywords/isopropyl-myristate","display_name":"isopropyl myristate","score":0.9100000262260437},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.7549999952316284},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hairless-mouse-skin","display_name":"hairless mouse skin","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9806032180786133},{"id":"https://openalex.org/C2779783494","wikidata":"https://www.wikidata.org/wiki/Q416222","display_name":"Isopropyl myristate","level":2,"score":0.8712149858474731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6864029169082642},{"id":"https://openalex.org/C2780508388","wikidata":"https://www.wikidata.org/wiki/Q1750127","display_name":"SN-38","level":5,"score":0.4728299081325531},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34683358669281006},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34184229373931885},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2872370481491089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18533173203468323},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.13263121247291565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10797655582427979},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0378-5173(01)00869-9","doi":"https://doi.org/10.1016/s0378-5173(01)00869-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-5173(01)00869-9","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7839000225067139}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1524526859","https://openalex.org/W1974437354","https://openalex.org/W1978143129","https://openalex.org/W1980977381","https://openalex.org/W1981173744","https://openalex.org/W1983819655","https://openalex.org/W2000275011","https://openalex.org/W2005787232","https://openalex.org/W2038632263","https://openalex.org/W2043607069","https://openalex.org/W2054384204","https://openalex.org/W2056681055","https://openalex.org/W2071953730","https://openalex.org/W2081766813","https://openalex.org/W2118372038","https://openalex.org/W2165828280","https://openalex.org/W4247826776","https://openalex.org/W4252111711","https://openalex.org/W6718540893"],"related_works":["https://openalex.org/W1981173744","https://openalex.org/W2015508543","https://openalex.org/W2165828280","https://openalex.org/W2000275011","https://openalex.org/W2081766813","https://openalex.org/W4252111711","https://openalex.org/W2071953730","https://openalex.org/W1581088900","https://openalex.org/W2019932867","https://openalex.org/W2054449983"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}