{"id":"https://openalex.org/W4246002002","doi":"https://doi.org/10.1146/annurev.med.42.1.567","title":"Growth Factors And Wound Healing: Platelet-Derived Growth Factor As A Model Cytokine","display_name":"Growth Factors And Wound Healing: Platelet-Derived Growth Factor As A Model Cytokine","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W4246002002","doi":"https://doi.org/10.1146/annurev.med.42.1.567"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.med.42.1.567","doi":"https://doi.org/10.1146/annurev.med.42.1.567","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.42.1.567","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060705509","display_name":"Thomas F. Deuel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T. Deuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060705509"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.8127,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.98817673,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"1","first_page":"567","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9480000138282776},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pdgf-receptor","display_name":"PDGF receptor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5450000166893005},{"id":"https://openalex.org/keywords/wound-care","display_name":"wound care","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.8442407846450806},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.8035306930541992},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.6827681064605713},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6696180105209351},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6389122605323792},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5684307813644409},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4990103244781494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4978482723236084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4671444594860077},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.45987194776535034},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.403725266456604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34987369179725647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0898967981338501}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1146/annurev.med.42.1.567","doi":"https://doi.org/10.1146/annurev.med.42.1.567","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.42.1.567","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.7699999809265137,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007523313","https://openalex.org/W2183242961","https://openalex.org/W2137577023","https://openalex.org/W2141676073","https://openalex.org/W2061914961","https://openalex.org/W2363921830","https://openalex.org/W7101166585","https://openalex.org/W2154636701","https://openalex.org/W1983360399","https://openalex.org/W1963633138"],"abstract_inverted_index":{"Cytokines":[0],"such":[1],"as":[2,111],"the":[3,9,20,41,46,55,76,84,115],"platelet-derived":[4],"growth":[5],"factor":[6],"(PDGF)":[7],"have":[8],"potential":[10],"to":[11,39,54,95],"initiate":[12,69],"and":[13,27,58,68],"mediate":[14],"many":[15],"if":[16],"not":[17],"all":[18],"of":[19,48,72,87,117],"complex":[21],"biological":[22],"responses":[23],"associated":[24],"with":[25,50],"inflammation":[26],"wound":[28,60,90,101],"healing.":[29],"PDGF":[30,49,63,92],"is":[31],"a":[32,88],"potent":[33],"cytokine":[34],"that":[35,105],"may":[36],"be":[37],"used":[38],"illustrate":[40],"diverse":[42],"activities":[43],"initiated":[44],"by":[45],"interactions":[47],"its":[51],"receptor":[52],"relevant":[53],"inflammatory":[56],"response":[57],"subsequent":[59],"repair.":[61],"Because":[62],"can":[64],"chemotactically":[65],"attract,":[66],"activate,":[67],"new":[70],"expression":[71],"quiescent":[73],"genes":[74],"(e.g.":[75],"small":[77],"inducible":[78],"gene,":[79],"SIG,":[80],"family),":[81],"it":[82],"fulfills":[83],"predictions":[85],"anticipated":[86],"candidate":[89],"hormone.":[91],"added":[93],"directly":[94],"experimental":[96],"wounds":[97,118],"in":[98,114,119],"animals":[99],"enhances":[100],"healing,":[102],"which":[103],"suggests":[104],"cytokines":[106],"will":[107],"become":[108],"increasingly":[109],"important":[110],"therapeutic":[112],"agents":[113],"treatment":[116],"humans.":[120]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}