{"id":"https://openalex.org/W4245964683","doi":"https://doi.org/10.1002/hep.25862","title":"Reply:","display_name":"Reply:","publication_year":2012,"publication_date":"2012-05-22","ids":{"openalex":"https://openalex.org/W4245964683","doi":"https://doi.org/10.1002/hep.25862"},"language":"en","primary_location":{"id":"doi:10.1002/hep.25862","doi":"https://doi.org/10.1002/hep.25862","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25862","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25862","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25862","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085570553","display_name":"Abhisek Mitra","orcid":"https://orcid.org/0000-0001-9168-4230","observed_orcids":["https://orcid.org/0000-0001-9168-4230"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhisek Mitra","raw_affiliation_strings":["Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024041787","display_name":"Jeffry J. Cutrera","orcid":"https://orcid.org/0000-0001-5110-6778","observed_orcids":["https://orcid.org/0000-0001-5110-6778"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffry Cutrera","raw_affiliation_strings":["Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091703176","display_name":"Lopa Mishra","orcid":"https://orcid.org/0000-0002-6850-0808","observed_orcids":["https://orcid.org/0000-0002-6850-0808"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lopa Mishra","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055203050","display_name":"Shulin Li","orcid":"https://orcid.org/0000-0001-5657-4183","observed_orcids":["https://orcid.org/0000-0001-5657-4183"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shulin Li","raw_affiliation_strings":["Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Research, Hepatology and Nutrition University of Texas MD Anderson Cancer Center Houston, TX<","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"6","first_page":"2425","last_page":"2425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-30","display_name":"interleukin-30","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.7279999852180481},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.871999979019165},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ebi3","display_name":"EBI3","score":0.800000011920929},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.703000009059906},{"id":"https://openalex.org/keywords/cancer-therapy-toxicity","display_name":"cancer therapy toxicity","score":0.4490000009536743},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5727201700210571},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5628845691680908},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5126001238822937},{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.48684805631637573},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4822426736354828},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4310251474380493},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4205089509487152},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41413554549217224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38340139389038086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37001529335975647},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34197425842285156},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3354009985923767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32812416553497314},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31676316261291504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20090025663375854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17653721570968628},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.051237016916275024}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/hep.25862","doi":"https://doi.org/10.1002/hep.25862","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25862","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25862","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/hep.25862","doi":"https://doi.org/10.1002/hep.25862","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25862","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25862","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4245964683.pdf","grobid_xml":"https://content.openalex.org/works/W4245964683.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1958199452","https://openalex.org/W1976660365","https://openalex.org/W1987718270","https://openalex.org/W2020798985","https://openalex.org/W2024992877","https://openalex.org/W2128475089","https://openalex.org/W2138040687","https://openalex.org/W6679385965"],"related_works":["https://openalex.org/W2067385855","https://openalex.org/W2020798985","https://openalex.org/W1976660365","https://openalex.org/W152424033","https://openalex.org/W2048746261","https://openalex.org/W1571743853","https://openalex.org/W2888460654","https://openalex.org/W2021679292","https://openalex.org/W2253819322","https://openalex.org/W2792759011"],"abstract_inverted_index":{"Based":[0],"on":[1,139],"our":[2],"findings,":[3],"it":[4],"is":[5,30,86,145,154,247,292],"conclusive":[6],"that":[7,31,60,121,162,198,226],"interleukin":[8],"(IL)-30":[9],"reduces":[10,184,318],"inflammation-induced":[11],"liver":[12,97,116,210,219,253,273],"injury;":[13],"however,":[14,143],"the":[15,34,58,61,66,74,158,170,194,269,290,319],"exact":[16],"mechanisms":[17],"are":[18],"not":[19,113],"clear.1":[20],"One":[21,118],"possible":[22],"mechanism":[23],"as":[24,311],"described":[25],"in":[26,89,93,101,103,127,135,141,159,176,187,189,239,255,289,304,327],"Dr.":[27,50,222],"Fujita's":[28],"letter":[29],"IL-30":[32,38,78,122,163,168,179,227,250,317],"inhibits":[33,43,169,251],"IL6-gp130-STAT3":[35,62],"pathway":[36,63],"because":[37,249,283],"binds":[39,164],"to":[40,80,125,131,148,156,165,207,218,232,314],"gp130":[41,81,126],"and":[42,82,228,258,351],"IL-6\u2013induced":[44],"STAT3":[45],"activation.2":[46],"As":[47],"indicated":[48],"by":[49],"Fujita,":[51],"such":[52,310],"an":[53,136],"explanation":[54],"may":[55,204,216,280],"conflict":[56],"with":[57,294],"fact":[59],"also":[64,224],"protects":[65],"liver.3":[67],"To":[68],"solve":[69],"this":[70,150],"paradox,":[71],"we":[72],"offer":[73],"following":[75],"explanation.":[76],"First,":[77],"binding":[79,130],"inhibiting":[83],"IL-6":[84,140,171,203,215,263,288,303],"signaling":[85],"only":[87],"reported":[88],"CD4+":[90],"T":[91,132,233],"cells":[92,111],"vitro,2":[94,177],"whereas":[95,212],"IL-6\u2013mediated":[96],"protection":[98],"primarily":[99],"occurs":[100],"hepatocytes":[102,128],"vivo.3":[104],"Signaling":[105],"through":[106],"2":[107],"different":[108],"types":[109],"of":[110,202,214,241,287,301,321,344,348,354],"will":[112],"antagonistically":[114],"prevent":[115],"injury.":[117],"could":[119],"argue":[120],"should":[123],"bind":[124,231],"if":[129],"cells,":[133],"resulting":[134,238],"antagonistic":[137],"effect":[138],"hepatocytes;":[142],"there":[144],"no":[146],"evidence":[147,153],"support":[149,157],"argument.":[151],"Further":[152],"needed":[155],"vitro":[160],"observation":[161],"gp130.":[166],"Second,":[167],"plus":[172],"TGF\u03b2-induced":[173],"IL-10":[174,185],"production":[175],"but":[178,268],"treatment":[180,326],"neither":[181],"increases":[182],"nor":[183],"level":[186,201,286],"serum":[188,291],"mice":[190],"(unpublished":[191],"data).":[192],"Finally,":[193],"published":[195],"data":[196],"indicate":[197],"a":[199,284],"physiological":[200],"be":[205,281],"beneficial":[206],"protect":[208],"from":[209,275],"injury,3":[211],"overexpression":[213],"lead":[217],"inflammation":[220],"(injury).4":[221],"Fujita":[223],"suggests":[225],"EBI3":[229],"competitively":[230],"cell":[234],"cytokine":[235],"receptor":[236],"(TCCR)":[237],"inhibition":[240],"inflammation.":[242],"This":[243],"competitive":[244],"binding-dependent":[245],"anti-inflammation":[246],"unlikely":[248],"IL-12\u2013mediated":[252],"toxicity":[254,320],"both":[256],"EBI3\u2212/\u2212":[257],"TCCR\u2212/\u2212":[259],"mice.1":[260,328],"In":[261],"conclusion,":[262],"might":[264],"act":[265],"toward":[266],"hepatoprotection,":[267],"application":[270],"for":[271,277],"protecting":[272],"injury":[274],"therapeutics":[276],"cancer":[278,296,305,324],"patients":[279,306],"prohibited":[282],"higher":[285],"associated":[293],"reduced":[295],"patients'":[297],"survival.4":[298],"Furthermore,":[299],"administration":[300],"recombinant":[302],"caused":[307],"toxic":[308],"effects":[309],"hepatoxicity.5":[312],"Contrary":[313],"these":[315],"examples,":[316],"IL-12":[322],"(a":[323],"therapeutic)":[325],"Abhisek":[329],"Mitra":[330],"Ph.D.*,":[331,334,341],"Jeffry":[332],"Cutrera":[333],"Lopa":[335],"Mishra":[336],"M.D.":[337],",":[338],"Shulin":[339],"Li":[340],"*":[342],"Department":[343,347],"Pediatrics":[345],"Research,":[346],"Gastroenterology,":[349],"Hepatology":[350],"Nutrition,":[352],"University":[353],"Texas":[355],"MD":[356],"Anderson":[357],"Cancer":[358],"Center,":[359],"Houston,":[360],"TX.":[361]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}
