{"id":"https://openalex.org/W4245883495","doi":"https://doi.org/10.1101/2021.01.14.426698","title":"Role of the mobilome in the global dissemination of the carbapenem resistance gene bla NDM","display_name":"Role of the mobilome in the global dissemination of the carbapenem resistance gene bla NDM","publication_year":2021,"publication_date":"2021-01-14","ids":{"openalex":"https://openalex.org/W4245883495","doi":"https://doi.org/10.1101/2021.01.14.426698"},"language":"en","primary_location":{"id":"doi:10.1101/2021.01.14.426698","doi":"https://doi.org/10.1101/2021.01.14.426698","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.14.426698","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/27/2021.01.14.426698.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/27/2021.01.14.426698.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016122562","display_name":"Mislav Acman","orcid":"https://orcid.org/0000-0003-2587-2836","observed_orcids":["https://orcid.org/0000-0003-2587-2836"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mislav Acman","raw_affiliation_strings":["UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK"],"raw_orcid":"https://orcid.org/0000-0003-2587-2836","affiliations":[{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778737","display_name":"Ruobing Wang","orcid":"https://orcid.org/0000-0002-9921-7271","observed_orcids":["https://orcid.org/0000-0002-9921-7271","https://orcid.org/0009-0001-8311-9167"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruobing Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075077326","display_name":"Lucy van Dorp","orcid":"https://orcid.org/0000-0002-6211-2310","observed_orcids":["https://orcid.org/0000-0002-6211-2310"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucy van Dorp","raw_affiliation_strings":["UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055049959","display_name":"Liam P. Shaw","orcid":"https://orcid.org/0000-0001-7332-0820","observed_orcids":["https://orcid.org/0000-0001-7332-0820"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liam P. Shaw","raw_affiliation_strings":["Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK","Department of Zoology, University of Oxford, Oxford OX1 SZ, UK"],"raw_orcid":"https://orcid.org/0000-0001-7332-0820","affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Zoology, University of Oxford, Oxford OX1 SZ, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341302","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0002-5270-2683","observed_orcids":["https://orcid.org/0000-0002-5270-2683"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030857363","display_name":"Nina Luhmann","orcid":"https://orcid.org/0000-0001-8112-7027","observed_orcids":["https://orcid.org/0000-0001-8112-7027"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nina Luhmann","raw_affiliation_strings":["Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK","Warwick Medical School, University of Warwick, Coventry CV 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Coventry CV 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101079872","display_name":"Yuyao Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyao Yin","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011839775","display_name":"Shijun Sun","orcid":"https://orcid.org/0000-0002-4389-541X","observed_orcids":["https://orcid.org/0000-0002-4389-541X","https://orcid.org/0009-0000-1163-1228"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijun Sun","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647913","display_name":"Hongbin Chen","orcid":"https://orcid.org/0000-0003-4607-1018","observed_orcids":["https://orcid.org/0000-0003-4607-1018"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbin Chen","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026861437","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0001-9220-0357","observed_orcids":["https://orcid.org/0000-0001-9220-0357"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060910782","display_name":"Fran\u00e7ois Balloux","orcid":"https://orcid.org/0000-0003-1978-7715","observed_orcids":["https://orcid.org/0000-0003-1978-7715"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francois Balloux","raw_affiliation_strings":["UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Genetics Institute, University College London, Gower Street, London, WCE 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016122562"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blandm","display_name":"blaNDM","score":0.8930000066757202},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mobile-genetic-elements","display_name":"mobile genetic elements","score":0.7680000066757202},{"id":"https://openalex.org/keywords/transposon-mediated-gene-transfer","display_name":"transposon-mediated gene transfer","score":0.5720000267028809},{"id":"https://openalex.org/keywords/is26","display_name":"IS26","score":0.7149999737739563},{"id":"https://openalex.org/keywords/plasmid-transfer","display_name":"plasmid transfer","score":0.7059999704360962},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.5509999990463257},{"id":"https://openalex.org/keywords/bacterial-genomes","display_name":"bacterial genomes","score":0.4059999883174896},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6779999732971191},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7979999780654907},{"id":"https://openalex.org/keywords/resistance-gene-dissemination","display_name":"resistance gene dissemination","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.8913115859031677},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.8112685084342957},{"id":"https://openalex.org/C132533263","wikidata":"https://www.wikidata.org/wiki/Q2347362","display_name":"Mobile genetic elements","level":4,"score":0.7383196949958801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7076626420021057},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6065337061882019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5549995303153992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5485506653785706},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.41700994968414307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41270166635513306},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22933140397071838}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.01.14.426698","doi":"https://doi.org/10.1101/2021.01.14.426698","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.14.426698","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/27/2021.01.14.426698.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.01.14.426698","doi":"https://doi.org/10.1101/2021.01.14.426698","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.14.426698","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/27/2021.01.14.426698.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1560085021","display_name":null,"funder_award_id":"81625014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1781462830","display_name":"An integrated approach to understand the emergence and spread of extensively resistant Gram-negative bacteria in China","funder_award_id":"MR/P007597/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2114779333","display_name":null,"funder_award_id":"81661138006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2962126082","display_name":"UCL Biosciences Big Data","funder_award_id":"BB/R01356X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3023544119","display_name":null,"funder_award_id":"MR/P007597/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3413189247","display_name":"The evolution of mobile genetic elements in Gram-negative bacteria","funder_award_id":"220422/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4943610202","display_name":null,"funder_award_id":"MR/P007597/1","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5815922380","display_name":null,"funder_award_id":"ISSF3","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6984955898","display_name":null,"funder_award_id":"NE/N019989/1","funder_id":"https://openalex.org/F4320334631","funder_display_name":"Natural Environment Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334631","display_name":"Natural Environment Research Council","ror":"https://ror.org/02b5d8509"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4245883495.pdf","grobid_xml":"https://content.openalex.org/works/W4245883495.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W564365797","https://openalex.org/W1911845649","https://openalex.org/W1966702924","https://openalex.org/W1974069002","https://openalex.org/W1981517066","https://openalex.org/W1995786478","https://openalex.org/W2008750362","https://openalex.org/W2009562400","https://openalex.org/W2010849870","https://openalex.org/W2014477899","https://openalex.org/W2027266940","https://openalex.org/W2053585506","https://openalex.org/W2096093282","https://openalex.org/W2098466396","https://openalex.org/W2099837668","https://openalex.org/W2107903949","https://openalex.org/W2111513008","https://openalex.org/W2114298945","https://openalex.org/W2120172561","https://openalex.org/W2120902911","https://openalex.org/W2122673596","https://openalex.org/W2127322768","https://openalex.org/W2128591967","https://openalex.org/W2131046586","https://openalex.org/W2136537244","https://openalex.org/W2136653513","https://openalex.org/W2139580695","https://openalex.org/W2141052558","https://openalex.org/W2142465581","https://openalex.org/W2142678478","https://openalex.org/W2149452073","https://openalex.org/W2154556219","https://openalex.org/W2159595761","https://openalex.org/W2159675211","https://openalex.org/W2164998314","https://openalex.org/W2165777692","https://openalex.org/W2169649507","https://openalex.org/W2173732482","https://openalex.org/W2174972341","https://openalex.org/W2243622740","https://openalex.org/W2249212087","https://openalex.org/W2274601509","https://openalex.org/W2318209259","https://openalex.org/W2322358787","https://openalex.org/W2337782070","https://openalex.org/W2345670278","https://openalex.org/W2397232002","https://openalex.org/W2417941126","https://openalex.org/W2537565528","https://openalex.org/W2540891146","https://openalex.org/W2563724683","https://openalex.org/W2587678577","https://openalex.org/W2612516986","https://openalex.org/W2765364600","https://openalex.org/W2775244680","https://openalex.org/W2788593837","https://openalex.org/W2789921435","https://openalex.org/W2794200070","https://openalex.org/W2884834061","https://openalex.org/W2894808609","https://openalex.org/W2901954177","https://openalex.org/W2905366281","https://openalex.org/W2911474856","https://openalex.org/W2913847081","https://openalex.org/W2920512604","https://openalex.org/W2950150251","https://openalex.org/W2952167528","https://openalex.org/W2971630607","https://openalex.org/W2993005136","https://openalex.org/W2999304916","https://openalex.org/W3021709386","https://openalex.org/W3039234910","https://openalex.org/W3040200619","https://openalex.org/W3081837804","https://openalex.org/W3118443291","https://openalex.org/W3151493862","https://openalex.org/W3181413934","https://openalex.org/W4233142859","https://openalex.org/W4233317564"],"related_works":["https://openalex.org/W4220689311","https://openalex.org/W4390010982","https://openalex.org/W4389030062","https://openalex.org/W2429040489","https://openalex.org/W7221784437","https://openalex.org/W4413227951","https://openalex.org/W4289638952","https://openalex.org/W7166489248","https://openalex.org/W4284881009","https://openalex.org/W4402843131"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"mobile":[2,130],"resistance":[3,228],"gene":[4,82],"bla":[5,28,61,80,109,124,142,184,213],"NDM":[6,9,29,62,81,110,125,143,185,214],"encodes":[7],"the":[8,23,55,58,79,119,128,171,216,225,246],"enzyme":[10],"which":[11],"hydrolyses":[12],"carbapenems,":[13],"a":[14,34,45,71,100,146,155,159,206],"class":[15],"of":[16,22,36,60,73,123,183,219,227,248],"antibiotics":[17],"used":[18],"to":[19,104,117,245,250],"treat":[20],"some":[21],"most":[24],"severe":[25],"bacterial":[26,76,112,252],"infections.":[27],"is":[30,230],"globally":[31],"distributed":[32],"across":[33,96],"variety":[35],"Gram-negative":[37],"bacteria":[38],"on":[39,145],"multiple":[40],"plasmids,":[41],"typically":[42],"located":[43],"within":[44],"highly":[46],"recombining":[47],"and":[48,92,126,133,199,215],"transposon-rich":[49],"genomic":[50,121],"region.":[51],"This":[52,114,221],"complexity":[53],"means":[54],"dynamics":[56],"underlying":[57],"dissemination":[59,226],"remain":[63],"poorly":[64],"resolved.":[65],"In":[66],"this":[67],"work,":[68],"we":[69,204],"compile":[70],"dataset":[72],"over":[74],"6000":[75],"genomes":[77],"harbouring":[78],"including":[83,195],"104":[84],"newly":[85],"generated":[86],"PacBio":[87],"hybrid":[88],"assemblies":[89],"from":[90],"clinical":[91],"livestock":[93],"associated":[94],"isolates":[95],"China.":[97],"We":[98,139,168],"develop":[99],"novel":[101],"computational":[102],"approach":[103],"track":[105],"structural":[106],"variants":[107],"surrounding":[108],"in":[111,135,166,179,192],"genomes.":[113],"allows":[115],"us":[116],"identify":[118],"prevalent":[120],"contexts":[122],"reconstruct":[127],"key":[129],"genetic":[131],"elements":[132,191],"events":[134],"its":[136,162],"global":[137,156],"spread.":[138],"estimate":[140],"that":[141,170,224],"emerged":[144],"Tn":[147,172,200],"125":[148,173],"transposon":[149,174,236],"before":[150],"1985":[151],"but":[152,186],"only":[153],"reached":[154],"prevalence":[157],"around":[158],"decade":[160],"after":[161],"first":[163],"recorded":[164],"observation":[165,222],"2005.":[167],"find":[169],"played":[175],"an":[176],"important":[177],"role":[178],"early":[180],"plasmid-mediated":[181],"jumps":[182],"was":[187],"overtaken":[188],"by":[189,233],"other":[190],"recent":[193],"years":[194],"IS26-flanked":[196],"pseudo-composite":[197],"transposons":[198],"3000":[201],".":[202],"Lastly,":[203],"observe":[205],"notable":[207],"correlation":[208],"between":[209],"plasmid":[210,239],"backbones":[211],"bearing":[212],"sampling":[217],"location":[218],"isolates.":[220],"suggests":[223],"genes":[229],"mainly":[231],"driven":[232],"successive":[234],"between-plasmid":[235],"jumps,":[237],"with":[238],"exchange":[240],"much":[241],"more":[242],"restricted":[243],"due":[244],"adaptation":[247],"plasmids":[249],"specific":[251],"hosts.":[253]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
