{"id":"https://openalex.org/W4245863813","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567","title":"Phase I study of oral irinotecan and temozolomide in children with relapsed high-risk neuroblastoma: A New Approach to Neuroblastoma Therapy (NANT) Consortium study","display_name":"Phase I study of oral irinotecan and temozolomide in children with relapsed high-risk neuroblastoma: A New Approach to Neuroblastoma Therapy (NANT) Consortium study","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W4245863813","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.9567","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058782198","display_name":"Lars M. Wagner","orcid":"https://orcid.org/0000-0003-4717-9960","observed_orcids":["https://orcid.org/0000-0003-4717-9960"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. M. Wagner","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035506178","display_name":"J. G. Villablanca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. G. Villablanca","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043293908","display_name":"Clinton F. Stewart","orcid":"https://orcid.org/0000-0002-1546-9720","observed_orcids":["https://orcid.org/0000-0002-1546-9720"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. F. Stewart","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085620590","display_name":"Kristine R. Crews","orcid":"https://orcid.org/0000-0002-7558-558X","observed_orcids":["https://orcid.org/0000-0002-7558-558X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. R. Crews","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. A. O'Shaughnessy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. O'Shaughnessy","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387322","display_name":"Susan G. Groshen","orcid":"https://orcid.org/0000-0001-9705-1012","observed_orcids":["https://orcid.org/0000-0001-9705-1012"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Groshen","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058354009","display_name":"C. Patrick Reynolds","orcid":"https://orcid.org/0000-0002-2827-8536","observed_orcids":["https://orcid.org/0000-0002-2827-8536"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. P. Reynolds","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004829099","display_name":"J. R. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Park","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Maris","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064007701","display_name":"K. K. Matthay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. K. Matthay","raw_affiliation_strings":["Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital, Cincinnati, OH; Children's Hospital of Los Angeles, Los Angeles, CA; St. Jude Children's Research Hospital, Memphis, TN; University of Southern California, Los Angeles, CA; Children's Hospital and Regional Medical Center, Seattle, WA; Children's Hospital of Philadelphia, Philadelphia, PA; University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1285204247","https://openalex.org/I1313298211","https://openalex.org/I1335321130","https://openalex.org/I1336910626","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"9567","last_page":"9567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.7850000262260437},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.843999981880188},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":1.0},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/relapsed-neuroblastoma","display_name":"relapsed neuroblastoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cefixime","display_name":"cefixime","score":0.8270000219345093},{"id":"https://openalex.org/keywords/diarrhea-prevention","display_name":"diarrhea prevention","score":0.796999990940094},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6949999928474426},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.453000009059906},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9187424182891846},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.7388205528259277},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7211686372756958},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5943126082420349},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5369206666946411},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.49987196922302246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4921078085899353},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4906841516494751},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.4780740737915039},{"id":"https://openalex.org/C2780508388","wikidata":"https://www.wikidata.org/wiki/Q1750127","display_name":"SN-38","level":5,"score":0.41527441143989563},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3587583899497986},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3005715012550354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26480185985565186},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10540884733200073},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.9567","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.9567","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124891389","https://openalex.org/W180617157","https://openalex.org/W2107325190","https://openalex.org/W2745118563","https://openalex.org/W2153188415","https://openalex.org/W1895063114","https://openalex.org/W2242006498","https://openalex.org/W2605049485","https://openalex.org/W2040275378","https://openalex.org/W2023128727"],"abstract_inverted_index":{"9567":[0],"Background:":[1],"Irinotecan":[2],"(IRN)":[3],"and":[4,10,20,67,73,93,117,129,138,183,262,277,302],"temozolomide":[5],"(TEM)":[6],"have":[7,118],"single-agent":[8,219],"activity":[9],"schedule-dependent":[11],"synergy":[12],"against":[13],"neuroblastoma.":[14],"Because":[15],"intravenous":[16,215],"IRN":[17,41,69,151,174,216,323],"is":[18,318],"costly":[19],"inconvenient,":[21],"especially":[22],"with":[23,43,47,75,105,213,228,274,328],"protracted":[24,214],"scheduling":[25],"common":[26],"in":[27,45,133,166,191,271,292,304,314],"pediatric":[28],"trials,":[29],"we":[30],"sought":[31],"to":[32,55,119,144,157,210,334],"determine":[33],"the":[34,52,134,173,196,218],"maximum":[35],"tolerated":[36,270],"dose":[37,205,309],"(MTD)":[38],"of":[39,108,168,176,250,280],"oral":[40,62,68],"combined":[42],"TEM":[44,63,139,319],"children":[46,273],"recurrent/resistant":[48],"high-risk":[49],"neuroblastoma,":[50,276],"using":[51],"antibiotic":[53],"cefixime":[54,82],"reduce":[56],"IRN-associated":[57],"diarrhea.":[58],"Methods:":[59],"Patients":[60],"received":[61,121],"on":[64,70,90,258],"days":[65,71],"1\u20135":[66,72],"8\u201312,":[74],"courses":[76,123,193,252,291],"repeated":[77],"every":[78],"21":[79],"days.":[80],"Oral":[81],"8":[83],"mg/kg":[84],"(max":[85],"400":[86],"mg/day)":[87],"was":[88,140,152,164,206,268,300],"started":[89],"day":[91],"-5":[92],"continued":[94],"daily.":[95],"Results:":[96],"Fifteen":[97],"patients":[98,170,223,243,256,283],"(median":[99,124],"age":[100],"7":[101,278],"years,":[102],"range":[103,126],"2\u201322)":[104],"a":[106,233,248],"median":[107,199,249],"3.5":[109],"previous":[110],"treatment":[111],"regimens":[112],"were":[113,131,181],"evaluable":[114,224,282],"for":[115,147,225,247,287,311],"toxicity":[116,189],"date":[120],"71":[122],"2,":[125],"1\u201319+).":[127],"Neutropenia":[128],"thrombocytopenia":[130],"dose-limiting":[132,165],"first":[135],"6":[136,169,239,288],"patients,":[137],"reduced":[141],"from":[142,155],"100":[143],"75":[145,320],"mg/m2/day":[146,321,325],"all":[148],"subsequent":[149],"patients.":[150],"then":[153],"escalated":[154],"30":[156],"60":[158,177,324],"mg/m2/day.":[159,178],"First-course":[160],"grade":[161,186],"3":[162],"diarrhea":[163],"1":[167],"treated":[171],"at":[172,195,203,217],"MTD":[175],"Other":[179],"toxicities":[180],"mild":[182],"reversible.":[184],"No":[185,330],"4":[187],"therapy-related":[188],"occurred":[190],"27":[192],"administered":[194],"MTD.":[197,220],"The":[198,308],"SN-38":[200],"lactone":[201],"AUC":[202],"this":[204,293,315],"72":[207],"ng*hr/ml,":[208],"similar":[209],"that":[211],"reported":[212],"Of":[221],"14":[222,281],"response,":[226],"one":[227],"measurable":[229],"nodal":[230],"disease":[231,246,286],"had":[232,244,284],"very":[234],"good":[235],"partial":[236],"response":[237],"through":[238],"courses.":[240,264],"Six":[241],"additional":[242],"stable":[245],"7.5":[251],"(range":[253],"6\u201319+).":[254],"Two":[255],"remain":[257],"study":[259,313],"after":[260],"10":[261],"19":[263],"Conclusions:":[265],"This":[266,297],"combination":[267],"well":[269],"heavily-pretreated":[272],"resistant":[275],"(50%)":[279],"response/stable":[285],"or":[289],"more":[290],"Phase":[294],"I":[295],"trial.":[296],"all-oral":[298],"regimen":[299],"feasible":[301],"resulted":[303],"favorable":[305],"SN-38-lactone":[306],"exposures.":[307],"recommended":[310],"further":[312],"patient":[316],"population":[317],"plus":[322],"when":[326],"given":[327],"cefixime.":[329],"significant":[331],"financial":[332],"relationships":[333],"disclose.":[335]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}