{"id":"https://openalex.org/W4245856873","doi":"https://doi.org/10.2172/10133997","title":"Nuclear magnetic resonance studies of the regulation of the pentose phosphate pathway","display_name":"Nuclear magnetic resonance studies of the regulation of the pentose phosphate pathway","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W4245856873","doi":"https://doi.org/10.2172/10133997"},"language":"en","primary_location":{"id":"doi:10.2172/10133997","doi":"https://doi.org/10.2172/10133997","is_oa":true,"landing_page_url":"https://doi.org/10.2172/10133997","pdf_url":"https://www.osti.gov/servlets/purl/10133997","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.osti.gov/servlets/purl/10133997","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147736100","display_name":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","raw_affiliation_strings":["Univ. of California, Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, Berkeley, CA (United States)","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065599244","display_name":"Nicolas R. Bolo","orcid":"https://orcid.org/0000-0002-9941-622X","observed_orcids":["https://orcid.org/0000-0002-9941-622X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Bolo","raw_affiliation_strings":["Univ. of California, Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, Berkeley, CA (United States)","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5147736100"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":1.0},{"id":"https://openalex.org/keywords/13c-nmr-spectroscopy","display_name":"13C NMR","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.796999990940094},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.9219260215759277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5117025375366211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45744889974594116},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4448028802871704},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4396047294139862},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.43803712725639343},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41701874136924744},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3744363486766815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26299577951431274},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2172/10133997","doi":"https://doi.org/10.2172/10133997","is_oa":true,"landing_page_url":"https://doi.org/10.2172/10133997","pdf_url":"https://www.osti.gov/servlets/purl/10133997","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)","raw_type":"report"},{"id":"pmh:oai:osti.gov:10133997","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/10133997","pdf_url":"https://www.osti.gov/servlets/purl/10133997","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.2172/10133997","doi":"https://doi.org/10.2172/10133997","is_oa":true,"landing_page_url":"https://doi.org/10.2172/10133997","pdf_url":"https://www.osti.gov/servlets/purl/10133997","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)","raw_type":"report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4245856873.pdf","grobid_xml":"https://content.openalex.org/works/W4245856873.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086558224","https://openalex.org/W2069516118","https://openalex.org/W2621311147","https://openalex.org/W2009550961","https://openalex.org/W3158013919","https://openalex.org/W2934303500","https://openalex.org/W2593363637","https://openalex.org/W2029941004","https://openalex.org/W2280406683","https://openalex.org/W6941002529"],"abstract_inverted_index":{"The":[0,60],"goal":[1],"of":[2,13,23,55,90,93,113,116,143,155,168,178,183,190],"this":[3],"work":[4,159],"is":[5,36,107],"to":[6,62,84,95,98,102,130],"investigate":[7],"the":[8,27,34,39,52,67,91,114,141,147,161,175,179,195,206],"potential":[9,162],"for":[10,21,163],"and":[11,50,57,133,185,193],"limitations":[12],"in":[14,33,48,51,76,122,164,200],"vivo":[15,165],"nuclear":[16],"magnetic":[17],"resonance":[18],"(NMR)":[19],"spectroscopy":[20,81],"quantitation":[22],"glucose":[24,144],"flux":[25,65,145],"through":[26,66,146],"pentose":[28,68,169],"phosphate":[29,170],"pathway":[30,171],"(shunt).":[31],"Interest":[32],"shunt":[35,69,86,120,148,191],"motivated":[37],"by":[38,88],"possibility":[40],"that":[41],"its":[42],"activity":[43,87,121,172,192],"may":[44],"be":[45],"greatly":[46],"increased":[47],"cancer":[49],"pathological":[53,77],"states":[54],"cardiac":[56],"cerebral":[58],"ischemia.":[59],"ability":[61],"dynamically":[63],"monitor":[64,85],"can":[70],"give":[71],"new":[72],"knowledge":[73],"about":[74],"metabolism":[75],"states.":[78],"13C":[79,180,201],"NMR":[80,202],"was":[82,149],"used":[83],"determination":[89],"ratios":[92],"[13C-4]":[94],"[13C-5]-glutamate,":[96],"[13C-3]":[97,101],"[13C-2]-alanine":[99],"or":[100],"[13C-2]-lactate":[103],"produced":[104],"when":[105],"[13C-2]-glucose":[106],"infused.":[108],"These":[109],"methods":[110],"provide":[111],"measures":[112],"effect":[115],"oxidative":[117],"stresses":[118],"on":[119,174,194],"systems":[123],"ranging":[124],"from":[125,205],"cell":[126,131,138],"free":[127,139],"enzyme-substrate":[128],"preparations":[129],"suspensions":[132],"whole":[134],"animals.":[135],"In":[136],"anaerobic":[137],"preparations,":[140],"fraction":[142],"monitored":[150],"with":[151],"a":[152,188],"time":[153],"resolution":[154],"3":[156],"minutes.":[157],"This":[158],"predicts":[160],"human":[166,203],"studies":[167,204],"based":[173],"mathematical":[176],"simulation":[177],"fractional":[181],"enrichments":[182],"C4":[184],"C5-glutamate":[186],"as":[187],"function":[189],"signal-to-":[196],"noise":[197],"ratio":[198],"acquired":[199],"current":[207],"literature.":[208]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2022-05-12T00:00:00"}
