{"id":"https://openalex.org/W4245847463","doi":"https://doi.org/10.1212/wnl.57.3.397","title":"A randomized, placebo-controlled trial of coenzyme Q 10 and remacemide in Huntington\u2019s disease","display_name":"A randomized, placebo-controlled trial of coenzyme Q 10 and remacemide in Huntington\u2019s disease","publication_year":2001,"publication_date":"2001-08-14","ids":{"openalex":"https://openalex.org/W4245847463","doi":"https://doi.org/10.1212/wnl.57.3.397","pmid":"https://pubmed.ncbi.nlm.nih.gov/11502903"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.57.3.397","doi":"https://doi.org/10.1212/wnl.57.3.397","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.57.3.397","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"The Huntington Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"The Huntington Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2159,"has_fulltext":false,"cited_by_count":315,"citation_normalized_percentile":{"value":0.97894334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"57","issue":"3","first_page":"397","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/remacemide","display_name":"remacemide","score":0.972000002861023},{"id":"https://openalex.org/keywords/functional-decline","display_name":"functional decline","score":0.8930000066757202},{"id":"https://openalex.org/keywords/total-functional-capacity","display_name":"total functional capacity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/early-stage-huntington-s-disease","display_name":"early-stage Huntington's disease","score":0.7039999961853027},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6349999904632568},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.730177104473114},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6026740074157715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5874589681625366},{"id":"https://openalex.org/C2779384338","wikidata":"https://www.wikidata.org/wiki/Q321285","display_name":"Coenzyme Q10","level":2,"score":0.5696789622306824},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5689891576766968},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5041483640670776},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.4795791208744049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.458965539932251},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.43596741557121277},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3652196526527405},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3576367497444153},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06432303786277771},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.57.3.397","doi":"https://doi.org/10.1212/wnl.57.3.397","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.57.3.397","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:11502903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G284047611","display_name":null,"funder_award_id":"RR 07122","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G426531767","display_name":"General Clinical Research Center","funder_award_id":"M01RR000044","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5000420942","display_name":null,"funder_award_id":"NS R01-35284","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5308670009","display_name":"COENZYME Q10 AND REMACEMIDE--EVALUATION IN HD","funder_award_id":"R01NS035284","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8297551062","display_name":"General Clinical Research Center","funder_award_id":"M01RR000042","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8970635779","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000645","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W979646749","https://openalex.org/W1965876571","https://openalex.org/W1975699010","https://openalex.org/W1998482324","https://openalex.org/W2030492299","https://openalex.org/W2036012667","https://openalex.org/W2051385624","https://openalex.org/W2055962836","https://openalex.org/W2084917270","https://openalex.org/W2092133936","https://openalex.org/W2102430316","https://openalex.org/W2105465219","https://openalex.org/W2109339856","https://openalex.org/W2111856493","https://openalex.org/W2119763594","https://openalex.org/W2153754131","https://openalex.org/W2154022596","https://openalex.org/W2166224121","https://openalex.org/W2606710341"],"related_works":["https://openalex.org/W2557765283","https://openalex.org/W2084728929","https://openalex.org/W2563108926","https://openalex.org/W1949056714","https://openalex.org/W2030492299","https://openalex.org/W2461636874","https://openalex.org/W2208199537","https://openalex.org/W2122916113","https://openalex.org/W2154022596","https://openalex.org/W1827375718"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"determine":[2],"whether":[3],"chronic":[4],"treatment":[5],"with":[6,39,122,162,170],"coenzyme":[7,49,123,171,177],"Q10":[8,50,124],"or":[9,63],"remacemide":[10,55,163,175],"hydrochloride":[11,56],"slows":[12],"the":[13,90,105,116,180],"functional":[14,94,187],"decline":[15,117,132,188],"of":[16,77,87,107,157,167],"early":[17,40,190],"Huntington's":[18],"disease":[19],"(HD).":[20],"METHODS:":[21],"The":[22,83],"authors":[23],"conducted":[24],"a":[25,75,126],"multicenter,":[26],"parallel":[27],"group,":[28],"double-blind,":[29],"2":[30,32],"x":[31],"factorial,":[33],"randomized":[34,46],"clinical":[35,108],"trial.":[36],"Research":[37],"participants":[38],"HD":[41],"(n":[42],"=":[43,142],"347)":[44],"were":[45,67],"to":[47,71],"receive":[48],"300":[51],"mg":[52,58],"twice":[53],"daily,":[54,61],"200":[57],"three":[59],"times":[60],"both,":[62],"neither":[64],"treatment,":[65],"and":[66,99,160,164],"evaluated":[68],"every":[69],"4":[70],"5":[72],"months":[73,79,136],"for":[74],"total":[76,93],"30":[78,100,135],"on":[80],"assigned":[81],"treatment.":[82],"prespecified":[84],"primary":[85],"measure":[86],"efficacy":[88],"was":[89,154],"change":[91],"in":[92,118,130,149,186,189],"capacity":[95],"(TFC)":[96],"between":[97],"baseline":[98],"months.":[101],"Safety":[102],"measures":[103],"included":[104],"frequency":[106,156,166],"adverse":[109],"events.":[110],"RESULTS:":[111],"Neither":[112,174],"intervention":[113],"significantly":[114],"altered":[115],"TFC.":[119],"Patients":[120],"treated":[121],"showed":[125],"trend":[127],"toward":[128],"slowing":[129,185],"TFC":[131],"(13%)":[133],"over":[134],"(2.40-":[137],"versus":[138],"2.74-point":[139],"decline,":[140],"p":[141],"0.15),":[143],"as":[144,146],"well":[145],"beneficial":[147],"trends":[148],"some":[150],"secondary":[151],"measures.":[152],"There":[153],"increased":[155,165],"nausea,":[158],"vomiting,":[159],"dizziness":[161],"stomach":[168],"upset":[169],"Q10.":[172],"CONCLUSIONS:":[173],"nor":[176],"Q10,":[178],"at":[179],"dosages":[181],"studied,":[182],"produced":[183],"significant":[184],"HD.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-05-12T00:00:00"}