{"id":"https://openalex.org/W4245446268","doi":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","title":"The p53 pathway","display_name":"The p53 pathway","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W4245446268","doi":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","doi":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080267048","display_name":"Carol L. Prives","orcid":"https://orcid.org/0000-0003-1846-5562","observed_orcids":["https://orcid.org/0000-0003-1846-5562"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Prives","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, 10027 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, 10027 U.S.A","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016493867","display_name":"Peter A. Hall","orcid":"https://orcid.org/0000-0002-0871-9576","observed_orcids":["https://orcid.org/0000-0002-0871-9576"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter A. Hall","raw_affiliation_strings":["Department of Cellular and Molecular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U.K","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016493867"],"corresponding_institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.0266,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86716958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"187","issue":"1","first_page":"112","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.859000027179718},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/arf","display_name":"ARF","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53-homologue","display_name":"p53 homologue","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.611710250377655},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5658102631568909},{"id":"https://openalex.org/C173366509","wikidata":"https://www.wikidata.org/wiki/Q206829","display_name":"Reductionism","level":2,"score":0.5524331331253052},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5499465465545654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521778404712677},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.5202861428260803},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4409360885620117},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.4331853985786438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2619197368621826},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20956063270568848},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.12593942880630493},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0870714783668518},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","doi":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083854544","https://openalex.org/W7097626867","https://openalex.org/W7099518905","https://openalex.org/W3159454489","https://openalex.org/W1772428425","https://openalex.org/W4388254026","https://openalex.org/W1496023203","https://openalex.org/W2161967149","https://openalex.org/W2115858839","https://openalex.org/W2146016446"],"abstract_inverted_index":{"Abnormalities":[0],"of":[1,23,31,59,72,81,84,91,111,124,130],"the":[2,9,24,29,45,57,60,79,89,118,127,139,158,163],"p53":[3,20,62,85,94,131],"tumour":[4],"suppressor":[5],"gene":[6],"are":[7,76,107,117],"among":[8],"most":[10,25],"frequent":[11],"molecular":[12],"events":[13],"in":[14,28,56,78,88,165],"human":[15],"and":[16,98,105,144,147,149],"animal":[17],"neoplasia.":[18],"Moreover,":[19],"is":[21,66,114,133,152],"one":[22],"studied":[26],"proteins":[27,101],"whole":[30],"contemporary":[32],"biology,":[33],"with":[34,100],"more":[35],"than":[36],"12500":[37],"papers":[38],"so":[39],"far":[40],"written!":[41],"In":[42],"this":[43,155],"review":[44],"choice":[46],"has":[47],"been":[48],"deliberately":[49],"made":[50],"not":[51],"to":[52,93],"be":[53],"fully":[54],"comprehensive":[55],"coverage":[58],"huge":[61],"literature.":[63],"Rather":[64],"attention":[65],"focused":[67],"on":[68],"a":[69],"small":[70],"number":[71],"recent":[73],"developments":[74],"which":[75],"reviewed":[77],"context":[80],"modern":[82],"models":[83],"function.":[86],"Progress":[87],"analysis":[90,151],"signalling":[92],"including":[95],"phosphorylation":[96],"cascades,":[97],"interactions":[99,113],"such":[102],"as":[103,116],"mdm2":[104],"ARF":[106],"highlighted.":[108],"The":[109,135],"plethora":[110],"protein\u2013protein":[112],"discussed,":[115],"strategies":[119],"for":[120,137,161],"defining":[121],"downstream":[122],"targets":[123],"p53.":[125],"Finally,":[126],"emerging":[128],"biology":[129],"homologues":[132],"considered.":[134],"need":[136],"bridging":[138],"gap":[140],"between":[141],"reductionist,":[142],"biochemical":[143],"biophysical":[145],"studies":[146],"biological":[148],"genetic":[150],"emphasized.":[153],"Only":[154],"will":[156],"provide":[157],"needed":[159],"framework":[160],"utilizing":[162],"information":[164],"clinical":[166],"care.":[167],"Copyright":[168],"\u00a9":[169],"1999":[170],"John":[171],"Wiley":[172],"&":[173],"Sons,":[174],"Ltd.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2022-05-12T00:00:00"}