{"id":"https://openalex.org/W4245434908","doi":"https://doi.org/10.1177/117693510600200026","title":"Plasma Protein Profiles Differ between Women Diagnosed with Cervical Intraepithelial Neoplasia (CIN) 1 and 3","display_name":"Plasma Protein Profiles Differ between Women Diagnosed with Cervical Intraepithelial Neoplasia (CIN) 1 and 3","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W4245434908","doi":"https://doi.org/10.1177/117693510600200026","mag":"1576810842","pmid":"https://pubmed.ncbi.nlm.nih.gov/19458776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2675504"},"language":"en","primary_location":{"id":"doi:10.1177/117693510600200026","doi":"https://doi.org/10.1177/117693510600200026","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510600200026","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/117693510600200026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003551118","display_name":"Chandrika Jayanthi Piyathilake","orcid":"https://orcid.org/0000-0003-3857-7035","observed_orcids":["https://orcid.org/0000-0003-3857-7035"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandrika J. Piyathilake","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057213757","display_name":"Denise K. Oelschlager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise K. Oelschlager","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024420238","display_name":"Sreelatha Meleth","orcid":"https://orcid.org/0000-0001-7149-8262","observed_orcids":["https://orcid.org/0000-0001-7149-8262"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreelatha Meleth","raw_affiliation_strings":["Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104507319","display_name":"Edward E. Partridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward E. Partridge","raw_affiliation_strings":["Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294","Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294","Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.2305,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67536523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":null,"first_page":"117693510600200","last_page":"117693510600200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.996999979019165},{"id":"https://openalex.org/keywords/cin1","display_name":"CIN1","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cin3","display_name":"CIN3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plasma-protein-profile","display_name":"plasma protein profile","score":0.7889999747276306},{"id":"https://openalex.org/keywords/seldi-tof-mass-spectrometry","display_name":"SELDI-TOF mass spectrometry","score":0.9070000052452087},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cervical-cancer-screening","display_name":"cervical cancer screening","score":0.765999972820282},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cervical-precancerous-lesions","display_name":"cervical precancerous lesions","score":0.6420000195503235},{"id":"https://openalex.org/keywords/classifier-development","display_name":"classifier development","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.8648701906204224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7253420948982239},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5974225401878357},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.5291949510574341},{"id":"https://openalex.org/C2777120189","wikidata":"https://www.wikidata.org/wiki/Q780067","display_name":"Triage","level":2,"score":0.4513397216796875},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.42636311054229736},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42031562328338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4192643165588379},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25703102350234985},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1177/117693510600200026","doi":"https://doi.org/10.1177/117693510600200026","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510600200026","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1442833","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2675504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2675504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2675504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Inform","raw_type":"Text"},{"id":"pmid:19458776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19458776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer informatics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:25bec184b53f4e3d98c540008c95a6be","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/25bec184b53f4e3d98c540008c95a6be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Informatics, Vol 2, Pp 345-349 (2006)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5d13db0bf3f54c8dad7a53187e8e1ade","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5d13db0bf3f54c8dad7a53187e8e1ade","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Informatics, Vol 2 (2006)","raw_type":"article"},{"id":"mag:1576810842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19458776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1177/117693510600200026","doi":"https://doi.org/10.1177/117693510600200026","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510600200026","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W138034249","https://openalex.org/W333391747","https://openalex.org/W1998221080","https://openalex.org/W2005364640","https://openalex.org/W2018840890","https://openalex.org/W2024377014","https://openalex.org/W2024633121","https://openalex.org/W2037365590","https://openalex.org/W2042708504","https://openalex.org/W2044523781","https://openalex.org/W2055695973","https://openalex.org/W2058164339","https://openalex.org/W2063376100","https://openalex.org/W2078342011","https://openalex.org/W2086207150","https://openalex.org/W2100288478","https://openalex.org/W2102260352","https://openalex.org/W2108725536","https://openalex.org/W2108835773","https://openalex.org/W2119580931","https://openalex.org/W2138445021","https://openalex.org/W2160658234","https://openalex.org/W2169556747","https://openalex.org/W2418874619","https://openalex.org/W2771358017"],"related_works":["https://openalex.org/W7097309949","https://openalex.org/W1948047042","https://openalex.org/W1983884013","https://openalex.org/W2381185557","https://openalex.org/W2060364224","https://openalex.org/W2913531263","https://openalex.org/W1966941193","https://openalex.org/W2124048158","https://openalex.org/W2100288478","https://openalex.org/W4318476580"],"abstract_inverted_index":{"Early":[0],"detection":[1],"of":[2,16,40,63,96,118,140,206],"precancerous":[3],"cells":[4],"in":[5,38,71,174,193],"the":[6,13,91,172,189,194,204],"cervix":[7],"and":[8,20,105,116,121,128,162,183,200],"their":[9],"clinical":[10],"management":[11],"is":[12,51],"main":[14],"purpose":[15],"cervical":[17,46,76],"cancer":[18],"prevention":[19],"treatment":[21],"programs.":[22],"Cytological":[23],"findings":[24],"or":[25],"testing":[26],"for":[27,36,45],"high":[28,43],"risk":[29,44],"(HR)-human":[30],"papillomavirus":[31],"(HPV)":[32],"are":[33,216],"inadequately":[34],"sensitive":[35],"use":[37],"triage":[39],"women":[41,85,100,107,214],"at":[42],"cancer.":[47],"The":[48,165,186],"current":[49],"study":[50,54],"an":[52,144],"exploratory":[53],"to":[55,149,170,212,218],"identify":[56,213],"candidate":[57],"surface-enhanced":[58],"laser":[59],"desorption/ionization":[60],"(SELDI)":[61],"time":[62],"flight":[64],"(TOF)":[65],"mass":[66],"spectrometry":[67],"(MS)":[68],"protein":[69,94,210],"profiles":[70,95,211],"plasma":[72,93,124,208],"that":[73,158,179],"may":[74],"distinguish":[75],"intraepithelial":[77],"neoplasia":[78],"(CIN":[79],"3)":[80],"from":[81,191],"CIN":[82,102,220],"1":[83],"among":[84],"infected":[86],"with":[87,101,108,197],"HR-HPV.":[88],"We":[89],"evaluated":[90],"SELDI-TOF-MS":[92],"HR-HPV":[97],"positive":[98],"32":[99],"3":[103,221],"(cases)":[104],"28":[106,160],"CIN1":[109],"(controls).":[110],"Case-control":[111],"status":[112],"was":[113,147,168],"kept":[114],"blinded":[115],"triplicates":[117],"each":[119],"sample":[120,131],"quality":[122],"control":[123],"samples":[125],"were":[126,133],"randomized":[127],"after":[129],"robotic":[130],"preparations":[132],"run":[134],"on":[135,153],"WCX2":[136],"chips.":[137],"After":[138],"alignment":[139],"mass/charge":[141],"(m-z":[142],"values),":[143],"iterative":[145],"method":[146],"used":[148,169],"develop":[150],"a":[151,154,175],"classifier":[152,166,187],"training":[155],"data":[156,177],"set":[157,178,196],"had":[159],"cases":[161,182,190],"22":[163],"controls.":[164,185],"developed":[167],"classify":[171],"subjects":[173],"test":[176,195],"has":[180],"six":[181,184],"separated":[188],"controls":[192],"100%":[198,201],"sensitivity":[199],"specificity":[202],"suggesting":[203],"possibility":[205],"using":[207],"SELDI":[209],"who":[215],"likely":[217],"have":[219],"lesions.":[222]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}