{"id":"https://openalex.org/W4245004741","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","title":"MUC5B Promoter Variant Potentiates the Unjammed State in Airway Epithelia","display_name":"MUC5B Promoter Variant Potentiates the Unjammed State in Airway Epithelia","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W4245004741","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","is_oa":true,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","pdf_url":"https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A4450","source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TP116. TP116 PRECLINICAL THERAPEUTIC MODELS OF FIBROSIS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A4450","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041748134","display_name":"Ian T. Stancil","orcid":"https://orcid.org/0000-0002-0215-3428","observed_orcids":["https://orcid.org/0000-0002-0215-3428"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I.T. Stancil","raw_affiliation_strings":["Medicine, University of Colorado School of Medicine, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Colorado School of Medicine, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037156446","display_name":"Jacob E. Michalski","orcid":"https://orcid.org/0000-0002-5937-570X","observed_orcids":["https://orcid.org/0000-0002-5937-570X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.E. Michalski","raw_affiliation_strings":["Medicine, University of Colorado School of Medicine, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Colorado School of Medicine, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044247934","display_name":"Jonathan S. Kurche","orcid":"https://orcid.org/0000-0002-4244-1870","observed_orcids":["https://orcid.org/0000-0002-4244-1870"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.S. Kurche","raw_affiliation_strings":["Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376759","display_name":"David A. Schwartz","orcid":"https://orcid.org/0000-0001-6743-8443","observed_orcids":["https://orcid.org/0000-0001-6743-8443"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. Schwartz","raw_affiliation_strings":["Medicine, University of Colorado School of Medicine, Aurora, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Colorado School of Medicine, Aurora, CO, United States","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A4450","last_page":"A4450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.13989999890327454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc5b","display_name":"MUC5B","score":0.9869999885559082},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mucus-secretion","display_name":"mucus secretion","score":0.531000018119812},{"id":"https://openalex.org/keywords/mucus-clearance","display_name":"mucus clearance","score":0.5839999914169312},{"id":"https://openalex.org/keywords/airway-mucus-hypersecretion","display_name":"airway mucus hypersecretion","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5594160556793213},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.5381250381469727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4151947498321533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39235934615135193},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3507940173149109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33877044916152954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18492412567138672},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1515408456325531},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.09406673908233643}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","is_oa":true,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","pdf_url":"https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A4450","source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TP116. TP116 PRECLINICAL THERAPEUTIC MODELS OF FIBROSIS","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","doi":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","is_oa":true,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4450","pdf_url":"https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A4450","source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TP116. TP116 PRECLINICAL THERAPEUTIC MODELS OF FIBROSIS","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4245004741.pdf","grobid_xml":"https://content.openalex.org/works/W4245004741.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225310648","https://openalex.org/W2333929242","https://openalex.org/W4414716126","https://openalex.org/W7145845474","https://openalex.org/W3041567933","https://openalex.org/W4246123684","https://openalex.org/W4285088571","https://openalex.org/W2780040586","https://openalex.org/W2334186584","https://openalex.org/W2321364778"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}