{"id":"https://openalex.org/W4245003255","doi":"https://doi.org/10.1016/j.jalz.2015.07.038","title":"O1\u201002\u201006: Neurite orientation dispersion and density imaging (NODDI) in young onset Alzheimer's disease and its syndromic variants","display_name":"O1\u201002\u201006: Neurite orientation dispersion and density imaging (NODDI) in young onset Alzheimer's disease and its syndromic variants","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W4245003255","doi":"https://doi.org/10.1016/j.jalz.2015.07.038"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2015.07.038","doi":"https://doi.org/10.1016/j.jalz.2015.07.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.07.038","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110277684","display_name":"Catherine F. Slattery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Catherine F. Slattery","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113906304","display_name":"Jiaying Zhang","orcid":"https://orcid.org/0009-0008-8122-2604","observed_orcids":["https://orcid.org/0009-0008-8122-2604"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jiaying Zhang","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074601909","display_name":"Ross W. Paterson","orcid":"https://orcid.org/0000-0001-9372-3635","observed_orcids":["https://orcid.org/0000-0001-9372-3635"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ross W. Paterson","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024606268","display_name":"Alexander Foulkes","orcid":"https://orcid.org/0000-0002-9402-7778","observed_orcids":["https://orcid.org/0000-0002-9402-7778"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander J.M. Foulkes","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020377507","display_name":"Laura Mancini","orcid":"https://orcid.org/0000-0002-4596-3551","observed_orcids":["https://orcid.org/0000-0002-4596-3551"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Mancini","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087017337","display_name":"David Lee Thomas","orcid":"https://orcid.org/0000-0003-1491-1641","observed_orcids":["https://orcid.org/0000-0003-1491-1641"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David L. Thomas","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018652821","display_name":"Marc Modat A","orcid":"https://orcid.org/0000-0002-5277-8530","observed_orcids":["https://orcid.org/0000-0002-5277-8530"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc Modat","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047729991","display_name":"Nicolas Toussaint","orcid":"https://orcid.org/0000-0003-4696-465X","observed_orcids":["https://orcid.org/0000-0003-4696-465X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas Toussaint","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042212695","display_name":"David M. Cash","orcid":"https://orcid.org/0000-0001-7833-616X","observed_orcids":["https://orcid.org/0000-0001-7833-616X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M. Cash","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026509971","display_name":"John S. Thornton","orcid":"https://orcid.org/0000-0003-3248-8437","observed_orcids":["https://orcid.org/0000-0003-3248-8437"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John S. Thornton","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033449704","display_name":"Daniel C. Alexander","orcid":"https://orcid.org/0000-0003-2439-350X","observed_orcids":["https://orcid.org/0000-0003-2439-350X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel C. Alexander","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082106258","display_name":"Sebastien Ourselin A","orcid":"https://orcid.org/0000-0002-5694-5340","observed_orcids":["https://orcid.org/0000-0002-5694-5340"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastien Ourselin","raw_affiliation_strings":["Centre for Medical Image Computing, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836358","display_name":"Nick C. Fox","orcid":"https://orcid.org/0000-0002-6660-657X","observed_orcids":["https://orcid.org/0000-0002-6660-657X"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick C. Fox","raw_affiliation_strings":["UCL Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685274","display_name":"Hui Gary Zhang","orcid":"https://orcid.org/0000-0002-5426-2140","observed_orcids":["https://orcid.org/0000-0002-5426-2140","https://orcid.org/0000-0003-2218-5619","https://orcid.org/0000-0002-6967-9141"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045615014","display_name":"Jonathan M. Schott","orcid":"https://orcid.org/0000-0003-2059-024X","observed_orcids":["https://orcid.org/0000-0003-2059-024X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan M. Schott","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110277684"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41120719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"7S_Part_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/noddi","display_name":"NODDI","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7083144187927246},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6526224613189697},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5619745850563049},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4558587670326233},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.41495466232299805},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3921140432357788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3355711102485657},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.27638012170791626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2230149507522583},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11115607619285583},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2015.07.038","doi":"https://doi.org/10.1016/j.jalz.2015.07.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.07.038","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336300460","https://openalex.org/W2765866937","https://openalex.org/W4245278378","https://openalex.org/W2897639280","https://openalex.org/W2792229831","https://openalex.org/W3110703067","https://openalex.org/W4406223299","https://openalex.org/W4206547904","https://openalex.org/W4414790391","https://openalex.org/W2559605011"],"abstract_inverted_index":{"Neurite":[0],"orientation":[1],"dispersion":[2],"and":[3,42,80,96,121,128,149,160,188,193,214,221,230,239,270,289],"density":[4,37,232,267],"imaging":[5,27,279],"(NODDI)":[6],"is":[7,300],"a":[8,50,63,112,207,301],"novel":[9],"MRI":[10],"technique":[11],"that":[12],"provides":[13],"more":[14],"anatomically":[15],"specific":[16,246],"microstructural":[17,69],"metrics":[18,166],"of":[19,45,52,67,218,265,292],"white":[20,70,284],"matter":[21,71,285],"damage":[22],"than":[23],"standard":[24,275],"diffusion":[25,114,276],"tensor":[26,247],"(DTI).":[28],"In":[29,206],"this":[30],"study":[31],"we":[32,211],"aimed":[33],"to":[34,170,182,274,283,304],"compare":[35],"neurite":[36,266,293],"index":[38,233],"(NDI)":[39,234],"using":[40,111,156,163,175],"NODDI":[41,118,152,157,263,278,299],"DTI":[43,173],"measures":[44,264],"fractional":[46],"anisotropy":[47,228],"(FA)":[48,229],"in":[49,186,216,259,287,295,308],"cohort":[51],"patients":[53,85,238],"with":[54,74,86,201],"young":[55],"onset":[56],"Alzheimer's":[57],"disease":[58],"(YOAD).":[59],"We":[60],"also":[61],"performed":[62],"preliminary":[64],"exploratory":[65,209],"comparison":[66],"the":[68,75,105,171,244],"signatures":[72],"associated":[73],"posterior":[76],"cortical":[77],"atrophy":[78],"(PCA)":[79],"amnestic":[81,222],"AD":[82,223,288,296],"phenotypes.":[83],"Twenty-six":[84],"YOAD":[87,237],"(age:":[88],"61.0\u00b15.5yrs,":[89],"33%":[90],"male,":[91],"age":[92,192],"at":[93,125],"symptom-onset":[94],"55.0\u00b14.3yrs)":[95],"19":[97],"controls":[98,240,260],"(age=61.0\u00b16.0yrs,":[99],"45%":[100],"male),":[101],"were":[102,145,154,167],"imaged":[103],"on":[104,243],"same":[106],"3T":[107],"Siemens":[108],"Trio":[109],"scanner":[110],"three-shell":[113],"sequence":[115],"optimised":[116],"for":[117,147,191,198,252,257],"(64,":[119],"32,":[120],"8":[122],"diffusion-weighted":[123],"directions":[124],"b=2000,":[126],"700":[127],"300":[129],"s/mm;":[130],"14":[131],"b=0":[132],"images;":[133],"55":[134],"slices;":[135],"voxel":[136],"size":[137],"2.5x2.5x2.5":[138],"mm;":[139],"TR/TE=7000/92":[140],"ms;":[141],"TA=15":[142],"mins).":[143],"Images":[144,250],"corrected":[146,197,251],"motion":[148],"eddy-current":[150],"distortion,":[151],"parameters":[153],"estimated":[155,162],"Matlab":[158],"toolbox,":[159],"FA":[161,187,215,258],"Camino.":[164],"Diffusion":[165],"spatially":[168],"normalized":[169],"population-specific":[172],"template":[174,248],"DTI-TK.":[176],"Tract-Based":[177],"Spatial":[178],"Statistics":[179],"was":[180],"used":[181],"detect":[183],"group":[184,245],"differences":[185,235],"NDI,":[189],"co-varying":[190],"gender":[194],"(5000":[195],"permutations":[196],"multiple":[199,253],"comparisons":[200],"Threshold-Free":[202],"Cluster":[203],"Enhancement":[204],"p<0.01).":[205],"secondary,":[208],"analysis":[210],"assessed":[212],"NDI":[213],"cohorts":[217],"PCA":[219],"(n=7)":[220,224],"versus":[225],"controls.":[226],"Fractional":[227],"neunte":[231],"between":[236],"(red)":[241],"shown":[242],"(green).":[249],"comparisons,":[254],"p<0.01":[255],"(p<0.05":[256],">":[261],"PCA).":[262],"provide":[268],"additional":[269],"complementary":[271],"information":[272],"compared":[273],"metrics.":[277],"reveals":[280],"widespread":[281],"disruption":[282],"architecture":[286],"differential":[290],"patterns":[291],"loss":[294],"syndromic":[297],"variants.":[298],"powerful":[302],"tool":[303],"investigate":[305],"neuronal":[306],"integrity":[307],"neurodegenerative":[309],"diseases.":[310]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}