{"id":"https://openalex.org/W4244975441","doi":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","title":"Immunocytochemical evidence for a diurnal rhythm of neurons showing colocalization of VIP with GRP in the rat suprachiasmatic nucleus","display_name":"Immunocytochemical evidence for a diurnal rhythm of neurons showing colocalization of VIP with GRP in the rat suprachiasmatic nucleus","publication_year":1998,"publication_date":"1998-02-16","ids":{"openalex":"https://openalex.org/W4244975441","doi":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","mag":"1965594161","pmid":"https://pubmed.ncbi.nlm.nih.gov/9492207"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","doi":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108397814","display_name":"H.J. Romijn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H.J. Romijn","raw_affiliation_strings":["Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077660776","display_name":"Arja A. Sluiter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.A. Sluiter","raw_affiliation_strings":["Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023616668","display_name":"Joke Wortel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Wortel","raw_affiliation_strings":["Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111598967","display_name":"J.F.M. Van Uum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.F.M. Van Uum","raw_affiliation_strings":["Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037569117","display_name":"Ruud M. Buijs","orcid":"https://orcid.org/0000-0003-3894-4632","observed_orcids":["https://orcid.org/0000-0003-3894-4632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.M. Buijs","raw_affiliation_strings":["Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108397814"],"corresponding_institution_ids":[],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.8537,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.72787279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"391","issue":"3","first_page":"397","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gastrin-releasing-peptide","display_name":"gastrin-releasing peptide","score":0.9750000238418579},{"id":"https://openalex.org/keywords/peptide-histidine-isoleucine","display_name":"peptide histidine isoleucine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuropeptide-co-localization","display_name":"neuropeptide co-localization","score":0.9480000138282776},{"id":"https://openalex.org/keywords/diurnal-cycle","display_name":"diurnal cycle","score":0.8730000257492065},{"id":"https://openalex.org/keywords/biological-clock","display_name":"biological clock","score":0.7979999780654907},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.6110000014305115},{"id":"https://openalex.org/keywords/neuropeptide-coexistence","display_name":"neuropeptide coexistence","score":0.6039999723434448},{"id":"https://openalex.org/keywords/zeitgeber-time","display_name":"Zeitgeber time","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.9567934274673462},{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.9258978366851807},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.8746297359466553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7619110345840454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5989271998405457},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5878696441650391},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.575022280216217},{"id":"https://openalex.org/C2776998989","wikidata":"https://www.wikidata.org/wiki/Q642462","display_name":"Gastrin-releasing peptide","level":5,"score":0.553368091583252},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5430999398231506},{"id":"https://openalex.org/C21786239","wikidata":"https://www.wikidata.org/wiki/Q185962","display_name":"Zeitgeber","level":4,"score":0.5311203002929688},{"id":"https://openalex.org/C2776459250","wikidata":"https://www.wikidata.org/wiki/Q640532","display_name":"Area postrema","level":3,"score":0.4760996103286743},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4323433041572571},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.391575425863266},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.2703656554222107},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2025010883808136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06785455346107483},{"id":"https://openalex.org/C2778448772","wikidata":"https://www.wikidata.org/wiki/Q349427","display_name":"Bombesin","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014660","descriptor_name":"Vasoactive Intestinal Peptide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019886","descriptor_name":"Gastrin-Releasing Peptide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","doi":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9861(19980216)391:3<397::aid-cne7>3.3.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:9492207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9492207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"},{"id":"pmh:knaw:oai:pure.knaw.nl:publications/0ac3adc0-9ade-466a-9155-680e819e8e2c","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/0ac3adc0-9ade-466a-9155-680e819e8e2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Comparative Neurology, 391, 397 - 405. Wiley-Liss Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.knaw.nl:openaire_cris_publications/0ac3adc0-9ade-466a-9155-680e819e8e2c","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/0ac3adc0-9ade-466a-9155-680e819e8e2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400439","display_name":"KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Romijn, H J, Sluiter, A A, Wortel, J, Uum, J V & Buijs, R M 1998, 'Immunocytochemical evidence for a diurnal rhythm of neurons showing colocalization of VIP with GRP in the rat suprachiasmatic nucleus', Journal of Comparative Neurology, vol. 391, pp. 397-405.","raw_type":"article"},{"id":"mag:1965594161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9492207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1498000437","https://openalex.org/W1639478343","https://openalex.org/W1650903045","https://openalex.org/W1921735617","https://openalex.org/W1963758132","https://openalex.org/W1971182992","https://openalex.org/W2001711337","https://openalex.org/W2011269189","https://openalex.org/W2014763859","https://openalex.org/W2015402598","https://openalex.org/W2016100098","https://openalex.org/W2018823590","https://openalex.org/W2020956121","https://openalex.org/W2026886271","https://openalex.org/W2026886275","https://openalex.org/W2041535208","https://openalex.org/W2044848427","https://openalex.org/W2049247251","https://openalex.org/W2049459124","https://openalex.org/W2049677726","https://openalex.org/W2051441400","https://openalex.org/W2062517355","https://openalex.org/W2068478903","https://openalex.org/W2071207364","https://openalex.org/W2080014607","https://openalex.org/W2089670675","https://openalex.org/W2113305956","https://openalex.org/W2129622853","https://openalex.org/W2144334843","https://openalex.org/W2592455005"],"related_works":["https://openalex.org/W2041535208","https://openalex.org/W2592455005","https://openalex.org/W2080014607","https://openalex.org/W1921735617","https://openalex.org/W2109169959","https://openalex.org/W2141304712","https://openalex.org/W2020956121","https://openalex.org/W2006787391","https://openalex.org/W2210671463","https://openalex.org/W2044848427"],"abstract_inverted_index":{"The":[0],"suprachiasmatic":[1],"nucleus":[2],"(SCN),":[3],"which":[4],"functions":[5],"as":[6,14],"a":[7,52,208],"biological":[8],"clock,":[9],"contains":[10],"several":[11,29],"neuropeptides":[12],"such":[13],"vasoactive":[15],"intestinal":[16],"peptide":[17,19,25],"(VIP),":[18],"histidine":[20],"isoleucine":[21],"(PHI),":[22],"and":[23,41,51,88,111,116,142,161,170,198],"gastrin-releasing":[24],"(GRP).":[26],"Studies":[27],"from":[28],"laboratories":[30],"have":[31],"provided":[32],"evidence":[33],"for":[34,106,114,228],"the":[35,47,59,79,82,90,94,102,107,120,147,159,173,180,183,186,190,213,222],"coexistence":[36],"of":[37,49,81,93,109,119,165,172,182,189,212,215,224],"VIP":[38,110,115,141,229],"with":[39,137],"PHI":[40,112,143],"GRP,":[42],"but":[43],"reliable":[44],"data":[45],"about":[46],"proportions":[48],"colocalization":[50,178],"possible":[53,155],"diurnal":[54],"rhythmicity":[55],"are":[56],"lacking.":[57],"In":[58],"present":[60],"study,":[61],"we":[62],"therefore":[63],"aimed":[64],"at":[65,146,162],"studying":[66],"these":[67,166,192],"aspects.":[68],"To":[69],"this":[70],"end,":[71],"rats":[72],"were":[73,104],"killed":[74],"by":[75,124],"perfusion":[76],"fixation":[77],"during":[78,89,158,179],"middle":[80,181],"day":[83,160],"(Zeitgeber":[84],"time":[85],"[ZT]":[86],"7)":[87],"second":[91,187],"part":[92,171,188],"night":[95],"(ZT":[96],"19).":[97],"Coronal":[98],"Vibratome":[99],"sections":[100,121],"through":[101],"SCN":[103],"double-immunolabeled":[105],"presence":[108],"or":[113,230],"GRP.":[117,231],"Analysis":[118],"was":[122,151,205],"done":[123],"semi-quantitative":[125],"confocal":[126],"laser":[127],"scanning":[128],"fluorescence":[129],"microscopy.":[130],"It":[131],"turned":[132],"out":[133],"that,":[134],"in":[135,153,203,219],"keeping":[136],"previous":[138],"literature":[139],"data,":[140],"always":[144],"coexist":[145],"cellular":[148],"level.":[149],"This":[150,201],"seen":[152],"all":[154],"ratios,":[156],"both":[157],"night.":[163],"Part":[164],"VIP/PHI-containing":[167],"neurons":[168,175],"(21%)":[169],"GRP-containing":[174],"(33%)":[176],"showed":[177],"day.":[184],"During":[185],"night,":[191],"percentages":[193,204],"increased":[194],"significantly":[195],"to":[196,207,221],"28%":[197],"40%,":[199],"respectively.":[200],"increase":[202,211],"due":[206],"significant,":[209],"nocturnal":[210],"number":[214,223],"profiles":[216,225],"showing":[217],"colocalization,":[218],"contrast":[220],"exclusively":[226],"immunoreactive":[227]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}