{"id":"https://openalex.org/W4244960066","doi":"https://doi.org/10.21203/rs.3.rs-153871/v2","title":"Incidence and Prognostic Significance of Liver Metastases for Newly Diagnosed Ovarian Cancer in Relation to Subtypes","display_name":"Incidence and Prognostic Significance of Liver Metastases for Newly Diagnosed Ovarian Cancer in Relation to Subtypes","publication_year":2021,"publication_date":"2021-07-28","ids":{"openalex":"https://openalex.org/W4244960066","doi":"https://doi.org/10.21203/rs.3.rs-153871/v2"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-153871/v2","doi":"https://doi.org/10.21203/rs.3.rs-153871/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-153871/v2","pdf_url":"https://www.researchsquare.com/article/rs-153871/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-153871/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101974282","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-3184-4447","observed_orcids":["https://orcid.org/0000-0002-3184-4447"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620669","display_name":"Yifang Zhang","orcid":"https://orcid.org/0009-0007-4696-0946","observed_orcids":["https://orcid.org/0009-0007-4696-0946","https://orcid.org/0000-0001-9415-3566","https://orcid.org/0000-0002-8732-1821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yifang Zhang","raw_affiliation_strings":["Department of Gynecology, Changxing people's hospital, Huzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Changxing people's hospital, Huzhou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108817358","display_name":"Lingyun Zhai","orcid":"https://orcid.org/0009-0004-4092-4053","observed_orcids":["https://orcid.org/0009-0004-4092-4053"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyun Zhai","raw_affiliation_strings":["Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373986","display_name":"Zhigang Zhang","orcid":"https://orcid.org/0000-0001-8965-223X","observed_orcids":["https://orcid.org/0000-0001-8965-223X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhigang Zhang","raw_affiliation_strings":["Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Hangzhou","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062562686","display_name":"Jianwei Zhou","orcid":"https://orcid.org/0009-0001-4667-9798","observed_orcids":["https://orcid.org/0009-0001-4667-9798"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Zhou","raw_affiliation_strings":["Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101974282"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ovarian-carcinosarcoma","display_name":"ovarian carcinosarcoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mucinous-ovarian-carcinoma","display_name":"mucinous ovarian carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cancer-specific-survival","display_name":"cancer-specific survival","score":0.8379999995231628},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/metastasis-incidence","display_name":"metastasis incidence","score":0.7559999823570251},{"id":"https://openalex.org/keywords/seer","display_name":"SEER","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7777307629585266},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7620866894721985},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7092506289482117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6093831658363342},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6093500256538391},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5978883504867554},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5301716327667236},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4585511386394501},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.45110028982162476},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.41833439469337463},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39144569635391235},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-153871/v2","doi":"https://doi.org/10.21203/rs.3.rs-153871/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-153871/v2","pdf_url":"https://www.researchsquare.com/article/rs-153871/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-153871/v2","doi":"https://doi.org/10.21203/rs.3.rs-153871/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-153871/v2","pdf_url":"https://www.researchsquare.com/article/rs-153871/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4244960066.pdf","grobid_xml":"https://content.openalex.org/works/W4244960066.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1990743451","https://openalex.org/W2023515204","https://openalex.org/W2032344344","https://openalex.org/W2103362208","https://openalex.org/W2438866487","https://openalex.org/W2616881692","https://openalex.org/W2700273100","https://openalex.org/W2802324884","https://openalex.org/W2807649309","https://openalex.org/W2860288606","https://openalex.org/W2897798645","https://openalex.org/W2906151320","https://openalex.org/W2985558334","https://openalex.org/W4211203170","https://openalex.org/W4248292785","https://openalex.org/W6606541536","https://openalex.org/W6751913978"],"related_works":["https://openalex.org/W3088297513","https://openalex.org/W2860288606","https://openalex.org/W4416760174","https://openalex.org/W1981205800","https://openalex.org/W4394933309","https://openalex.org/W3113810829","https://openalex.org/W2506092612","https://openalex.org/W3034579075","https://openalex.org/W4220745425","https://openalex.org/W3212108649"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Ovarian":[2],"cancer":[3,63,111,156,164,210,228],"is":[4,14],"a":[5],"heterogeneous":[6],"and":[7,11,33,54,92,131,212,224],"aggressive":[8],"malignant":[9],"tumor,":[10],"the":[12,17,31,51,61,82,105,136,139,145,162,185,202,213,225,235],"liver":[13,42,85,117,132,167,198,217,230],"one":[15,200],"of":[16,24,36,84,144,201,216],"most":[18,203],"common":[19,204],"metastases":[20,43,86],"target":[21],"visceral":[22,206],"organs":[23,207],"ovarian":[25,47,62,110,125,155,163,209,227],"cancer.":[26,48],"We":[27],"aim":[28],"to":[29,67,74,98],"analysis":[30],"incidence":[32,120,214],"prognostic":[34],"relevance":[35],"histological":[37,77,106],"subtypes":[38],"for":[39,153,208,221],"patients":[40,64,127,157],"with":[41,81,102,116,165,229,234],"in":[44,138],"newly":[45],"diagnosed":[46],"Methods:":[49],"In":[50],"Surveillance,":[52],"Epidemiology,":[53],"End":[55],"Results":[56],"(SEER)":[57],"database,":[58],"we":[59],"identified":[60],"from":[65],"2010":[66],"2016.":[68],"Multivariable":[69],"logistic":[70],"regression":[71,95],"was":[72,96,135,158,169,199],"used":[73],"determine":[75],"whether":[76],"types":[78],"were":[79,122,219],"associated":[80,101,233],"presence":[83],"at":[87],"diagnosis.":[88],"The":[89,119,148,172],"Kaplan-Meier":[90],"method":[91],"multivariable":[93],"Cox":[94],"performed":[97],"identify":[99],"covariates":[100],"survival":[103,151,188],"using":[104],"types.Results:":[107],"Among":[108],"25293":[109],"patients,":[112],"1749":[113],"cases":[114],"presented":[115],"metastases.":[118],"proportions":[121,215],"highest":[123,137,220],"among":[124,189],"carcinosarcoma":[126],"(OR=17.76,":[128],"95%":[129,180],"CI=9.26-34.09),":[130],"metastasis":[133,168,218,231],"specificity":[134],"clear":[140],"cell":[141],"type":[142],"(70.69%":[143],"metastatic":[146],"subset).":[147],"median":[149,187],"cancer-specific":[150],"(CSS)":[152],"non-metastatic":[154],"77":[159],"months,":[160],"but":[161],"only":[166],"21":[170],"months.":[171],"mucinous":[173,226],"(5":[174],"months;":[175],"vs":[176],"nonepithelial":[177],"subtype,":[178,223],"HR=0.26;":[179],"CI,":[181],"0.14-0.49)":[182],"subtype":[183],"experienced":[184],"shortest":[186],"all":[190],"histologic":[191],"types.Conclusion:":[192],"This":[193],"population-based":[194],"study":[195],"provides":[196],"that":[197],"distant":[205],"metastasis,":[211],"carcinosarcomas":[222],"being":[232],"poorest":[236],"survival.":[237]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}
