{"id":"https://openalex.org/W42447265","doi":null,"title":"Potentialisation de la chimioth\u00e9rapie par doc\u00e9taxel par la curcumine dans les cancers du sein m\u00e9tastatiques : \u00e9tudes exp\u00e9rimentales et clinique","display_name":"Potentialisation de la chimioth\u00e9rapie par doc\u00e9taxel par la curcumine dans les cancers du sein m\u00e9tastatiques : \u00e9tudes exp\u00e9rimentales et clinique","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W42447265","mag":"42447265"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/842603","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/842603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009054255","display_name":"Mathilde Bayet\u2010Robert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mathilde Bayet\u2010Robert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009054255"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.8730000257492065},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.996999979019165},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemotherapy-potentiation","display_name":"chemotherapy potentiation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8199999928474426},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.890999972820282},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.6320000290870667},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8171583414077759},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7878594398498535},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.5206250548362732},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19424551725387573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0787208080291748}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/842603","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/842603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:42447265","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2009CLF1PP06","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7023795388","https://openalex.org/W7153770392","https://openalex.org/W4402620742","https://openalex.org/W2095032594","https://openalex.org/W7096176034","https://openalex.org/W4393331483","https://openalex.org/W117069746","https://openalex.org/W2209869679","https://openalex.org/W7135311167","https://openalex.org/W7222767849"],"abstract_inverted_index":{"Le":[0],"traitement":[1,33,70],"des":[2,48,57,83,111,161,167,213],"cancers":[3,36],"du":[4,71,73,127,152,177,204,218],"sein":[5,74,219],"au":[6],"stade":[7],"m\u00e9tastatique":[8],"repose":[9],"notamment":[10],"sur":[11,80,164],"l'utilisation":[12],"de":[13,32,34,46,64,94,114,154,158,171,189,202,210,237,242],"la":[14,81,87,95,103,121,155,159,197,200],"chimioth\u00e9rapie.":[15],"Parmi":[16],"les":[17,20,78,109],"traitements":[18],"cytotoxiques":[19],"plus":[21],"efficaces,":[22],"le":[23,69,165],"doc\u00e9taxel":[24,205],"est":[25,67],"utilis\u00e9":[26,99],"en":[27,29,52,224],"monoth\u00e9rapie":[28],"1\u00e8re":[30],"ligne":[31],"ces":[35],"m\u00e9tastatiques.":[37],"Cependant,":[38],"son":[39],"efficacit\u00e9":[40],"n'est":[41],"pas":[42],"optimale":[43],"car":[44],"moins":[45],"5%":[47],"patients":[49,58,214],"trait\u00e9s":[50],"sont":[51],"r\u00e9ponse":[53,82],"compl\u00e8te":[54],"et":[55,76,133,157,199,228],"1/3":[56],"auront":[59],"une":[60,100,148,207,234],"rechute":[61],"m\u00e9tastatique.":[62,220],"L'objectif":[63],"ce":[65],"travail":[66],"d'optimiser":[68],"cancer":[72,217],"m\u00e9tastatique,":[75],"d'approfondir":[77],"connaissances":[79],"cellules":[84,168],"tumorales":[85],"\u00e0":[86,107,206],"chimioth\u00e9rapie":[88],"par":[89,147,174],"doc\u00e9taxel.":[90],"Pour":[91],"potentialiser":[92],"l'efficacit\u00e9":[93,241],"chimioth\u00e9rapie,":[96],"nous":[97,144,183,230],"avons":[98,119,145,184],"approche":[101],"nouvelle,":[102],"nutrith\u00e9rapie,":[104],"qui":[105],"consiste":[106],"utiliser":[108],"propri\u00e9t\u00e9s":[110],"phytonutriments":[112],"ou":[113],"compos\u00e9s":[115],"d'origine":[116],"alimentaire.":[117],"Nous":[118],"choisi":[120],"curcumine,":[122],"un":[123,141,180,186,216],"d\u00e9riv\u00e9":[124],"polyph\u00e9nolique":[125],"extrait":[126],"curcuma,":[128],"largement":[129],"\u00e9tudi\u00e9":[130,146],"in":[131,134],"vitro":[132],"vivo":[135],"pour":[136],"ses":[137],"effets":[138],"chimiopr\u00e9ventifs.":[139],"Dans":[140,179],"1er":[142],"temps,":[143,182],"analyse":[149],"m\u00e9tabolomique":[150],"l'impact":[151],"doc\u00e9taxel,":[153],"curcumine":[156,211],"combinaison":[160],"2":[162],"agents":[163],"m\u00e9tabolisme":[166],"humaines":[169],"MCF-7":[170],"tumeur":[172],"mammaire":[173],"spectroscopie":[175],"RMN":[176],"proton.":[178],"2nd":[181],"conduit":[185],"essai":[187],"clinique":[188,236],"phase":[190,238],"I":[191],"dont":[192],"l'objectif":[193],"principal":[194],"\u00e9tait":[195],"d'\u00e9tudier":[196],"tol\u00e9rance":[198],"faisabilit\u00e9":[201],"l'association":[203],"suppl\u00e9mentation":[208],"orale":[209],"chez":[212],"pr\u00e9sentant":[215],"Les":[221],"r\u00e9sultats":[222],"prometteurs":[223],"terme":[225],"d'efficacit\u00e9":[226],"antitumorale":[227],"anti-angiog\u00e9nique":[229],"orientent":[231],"ainsi":[232],"vers":[233],"\u00e9tude":[235],"II":[239],"\u00e9valuant":[240],"cette":[243],"association.":[244]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
