{"id":"https://openalex.org/W4244628628","doi":"https://doi.org/10.3109/s10165-009-0154-4","title":"Time of initial appearance of renal symptoms in the course of systemic lupus erythematosus as a prognostic factor for lupus nephritis","display_name":"Time of initial appearance of renal symptoms in the course of systemic lupus erythematosus as a prognostic factor for lupus nephritis","publication_year":2009,"publication_date":"2009-03-09","ids":{"openalex":"https://openalex.org/W4244628628","doi":"https://doi.org/10.3109/s10165-009-0154-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/19277827"},"language":"en","primary_location":{"id":"doi:10.3109/s10165-009-0154-4","doi":"https://doi.org/10.3109/s10165-009-0154-4","is_oa":false,"landing_page_url":"https://doi.org/10.3109/s10165-009-0154-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101645429","display_name":"Yuko Takahashi","orcid":"https://orcid.org/0000-0002-6419-3302","observed_orcids":["https://orcid.org/0000-0002-6419-3302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Takahashi","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, Shinjuku-ku, Tokyo, Japan","Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, Shinjuku-ku, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014601065","display_name":"Tetsuya Mizoue","orcid":"https://orcid.org/0000-0002-1198-2228","observed_orcids":["https://orcid.org/0000-0002-1198-2228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuya Mizoue","raw_affiliation_strings":["Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023539855","display_name":"Akitake Suzuki","orcid":"https://orcid.org/0000-0003-0490-3795","observed_orcids":["https://orcid.org/0000-0003-0490-3795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akitake Suzuki","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102779026","display_name":"Hiroyuki Yamashita","orcid":"https://orcid.org/0000-0002-0022-1941","observed_orcids":["https://orcid.org/0000-0002-0022-1941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Yamashita","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104365964","display_name":"Junwa Kunimatsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junwa Kunimatsu","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103184166","display_name":"Kenji Itoh","orcid":"https://orcid.org/0000-0002-4122-2983","observed_orcids":["https://orcid.org/0000-0002-4122-2983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Itoh","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103403531","display_name":"Akio Mimori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Akio Mimori","raw_affiliation_strings":["Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103403531"],"corresponding_institution_ids":[],"apc_list":{"value":3208,"currency":"USD","value_usd":3208},"apc_paid":null,"fwci":0.5829,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.67794702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"19","issue":"3","first_page":"293","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/remission-duration","display_name":"remission duration","score":0.7179999947547913},{"id":"https://openalex.org/keywords/class-iv-lupus-nephritis","display_name":"class IV lupus nephritis","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9424898624420166},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.8201491832733154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.707878828048706},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5746623873710632},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.552959144115448},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4968154728412628},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19800207018852234}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/s10165-009-0154-4","doi":"https://doi.org/10.3109/s10165-009-0154-4","is_oa":false,"landing_page_url":"https://doi.org/10.3109/s10165-009-0154-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"doi:10.1007/s10165-009-0154-4","doi":"https://doi.org/10.1007/s10165-009-0154-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10165-009-0154-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:19277827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19277827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1975988828","https://openalex.org/W1998540145","https://openalex.org/W2003820403","https://openalex.org/W2036892337","https://openalex.org/W2045139782","https://openalex.org/W2047722521","https://openalex.org/W2053289548","https://openalex.org/W2071299644","https://openalex.org/W2077133313","https://openalex.org/W2107871522","https://openalex.org/W2111940985","https://openalex.org/W2146203649","https://openalex.org/W2321889993","https://openalex.org/W2396173203","https://openalex.org/W3156996711"],"related_works":["https://openalex.org/W3094569258","https://openalex.org/W3207713850","https://openalex.org/W4406453993","https://openalex.org/W3047299977","https://openalex.org/W4399483943","https://openalex.org/W2909792224","https://openalex.org/W4413994547","https://openalex.org/W6966078315","https://openalex.org/W7214554121","https://openalex.org/W3045379920"],"abstract_inverted_index":{"The":[0],"prognosis":[1],"of":[2,25,38,48,58,68,78,104,117,151,194,200],"lupus":[3,18,195],"nephritis":[4,196],"(LN)":[5],"was":[6,120,183],"studied":[7],"retrospectively":[8],"in":[9,122,155,185,188,197],"two":[10],"LN":[11,13,24,60,190],"categories,":[12],"manifested":[14],"initially":[15],"at":[16,97],"systemic":[17],"erythematosus":[19],"(SLE)":[20],"onset":[21,30],"(I-LN)":[22],"and":[23,53,89,146],"delayed":[26],"manifestation":[27],"after":[28,86],"SLE":[29,40,201],"(D-LN),":[31],"based":[32],"on":[33],"a":[34,45,54,114,148],"chart":[35],"review":[36],"(C)":[37,187],"154":[39],"(85":[41],"LN)":[42],"patients":[43,61,80,93,105,127,160,186],"with":[44,65,125,158],"mean":[46,66],"observation":[47,67],"20.8":[49],"+/-":[50,70],"9.3":[51],"years":[52],"questionnaire":[55],"study":[56,75],"(Q)":[57],"125":[59],"outside":[62],"our":[63],"hospital":[64],"17.6":[69],"9.2":[71],"years.":[72],"In":[73],"both":[74,189],"groups,":[76],"half":[77],"I-LN":[79,92,123,159],"were":[81],"relapse-free":[82,100],"by":[83],"Kaplan-Meier":[84],"analysis":[85],"initial":[87,107],"therapy,":[88],"the":[90,198],"relapsed":[91],"responded":[94],"to":[95],"retherapy":[96],"higher":[98,115,149],"5-year":[99],"rates":[101],"than":[102],"those":[103],"receiving":[106],"therapies":[108],"for":[109],"D-LN.":[110],"At":[111],"last":[112],"observation,":[113],"frequency":[116,150],"prolonged":[118],"remission":[119],"shown":[121],"compared":[124,157],"D-LN":[126,156],"(C:":[128,161],"22/31,":[129],"71%":[130],"versus":[131,140,164,173],"14/49,":[132],"29%,":[133],"P":[134,143,167,176],"<":[135,144,168,177],"0.01;":[136],"Q:":[137,170],"65/89,":[138],"73%":[139],"11/33,":[141],"33%":[142],"0.01)":[145],"also":[147],"irreversible":[152],"renal":[153,204],"damage":[154],"25/49,":[162],"51%":[163],"2/31,":[165],"6%,":[166],"0.001;":[169],"14/33,":[171],"42%":[172],"6/89,":[174],"7%,":[175],"0.001),":[178],"although":[179],"class":[180],"IV":[181],"pathology":[182],"common":[184],"categories.":[191],"Onset":[192],"time":[193],"course":[199],"may":[202],"affect":[203],"prognosis.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}