{"id":"https://openalex.org/W4244546237","doi":"https://doi.org/10.1021/jo00333a015","title":"Analgesic narcotic antagonists. 10. Preparation of 8-alkyl-14-hydroxydihydrocodeinones","display_name":"Analgesic narcotic antagonists. 10. Preparation of 8-alkyl-14-hydroxydihydrocodeinones","publication_year":1981,"publication_date":"1981-09-01","ids":{"openalex":"https://openalex.org/W4244546237","doi":"https://doi.org/10.1021/jo00333a015"},"language":"en","primary_location":{"id":"doi:10.1021/jo00333a015","doi":"https://doi.org/10.1021/jo00333a015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo00333a015","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070032239","display_name":"David L. Leland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Leland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082486178","display_name":"Joseph O. Polazzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph O. Polazzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004437103","display_name":"Michael P. Kotick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael P. Kotick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2726,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.54582965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"20","first_page":"4012","last_page":"4014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.08669999986886978,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.7850000262260437},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9181797504425049},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.8260165452957153},{"id":"https://openalex.org/C2910878864","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Narcotic antagonists","level":5,"score":0.771571159362793},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.6112983226776123},{"id":"https://openalex.org/C2775849661","wikidata":"https://www.wikidata.org/wiki/Q940","display_name":"Narcotic","level":2,"score":0.5901256203651428},{"id":"https://openalex.org/C2909432430","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic agents","level":3,"score":0.5278052091598511},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40685784816741943},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.26281818747520447},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2273443639278412},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.19113075733184814},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.1304006576538086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jo00333a015","doi":"https://doi.org/10.1021/jo00333a015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo00333a015","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971498684","https://openalex.org/W1975330180","https://openalex.org/W1964876118","https://openalex.org/W2028983284","https://openalex.org/W2411126305","https://openalex.org/W2430664155","https://openalex.org/W2343669430","https://openalex.org/W2048283025","https://openalex.org/W2951620121","https://openalex.org/W2017761232"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTAnalgesic":[3],"narcotic":[4],"antagonists.":[5],"10.":[6],"Preparation":[7],"of":[8,52,87,113],"8-alkyl-14-hydroxydihydrocodeinonesDavid":[9],"L.":[10],"Leland,":[11],"Joseph":[12],"O.":[13],"Polazzi,":[14],"and":[15,62,67,96,140,157,173,175],"Michael":[16],"P.":[17],"KotickCite":[18],"this:":[19],"J.":[20],"Org.":[21],"Chem.":[22],"1981,":[23],"46,":[24],"20,":[25],"4012\u20134014Publication":[26],"Date":[27],"(Print):September":[28],"1,":[29],"1981Publication":[30],"History":[31],"Published":[32],"online1":[33],"May":[34],"2002Published":[35],"inissue":[36],"1":[37],"September":[38],"1981https://pubs.acs.org/doi/10.1021/jo00333a015https://doi.org/10.1021/jo00333a015research-articleACS":[39],"PublicationsRequest":[40],"reuse":[41],"permissionsArticle":[42],"Views121Altmetric-Citations6LEARN":[43],"ABOUT":[44],"THESE":[45],"METRICSArticle":[46],"Views":[47],"are":[48,71,84],"the":[49,80,85,114,125,138,141,146,153,159],"COUNTER-compliant":[50],"sum":[51],"full":[53],"text":[54],"article":[55,119],"downloads":[56],"since":[57],"November":[58],"2008":[59],"(both":[60],"PDF":[61],"HTML)":[63],"across":[64],"all":[65],"institutions":[66],"individuals.":[68],"These":[69],"metrics":[70],"regularly":[72],"updated":[73,97],"to":[74,79],"reflect":[75],"usage":[76],"leading":[77],"up":[78],"last":[81],"few":[82],"days.Citations":[83],"number":[86],"other":[88],"articles":[89],"citing":[90],"this":[91],"article,":[92],"calculated":[93],"by":[94],"Crossref":[95,103],"daily.":[98],"Find":[99,149],"more":[100,150],"information":[101,151],"about":[102,137],"citation":[104],"counts.The":[105],"Altmetric":[106,154],"Attention":[107,155],"Score":[108,156],"is":[109,161],"a":[110,117,130],"quantitative":[111],"measure":[112],"attention":[115],"that":[116],"research":[118],"has":[120],"received":[121],"online.":[122],"Clicking":[123],"on":[124,152],"donut":[126],"icon":[127],"will":[128],"load":[129],"page":[131],"at":[132],"altmetric.com":[133],"with":[134,169],"additional":[135],"details":[136],"score":[139,160],"social":[142],"media":[143],"presence":[144],"for":[145],"given":[147],"article.":[148],"how":[158],"calculated.":[162],"Share":[163,178],"Add":[164],"toView":[165],"InAdd":[166],"Full":[167],"Text":[168],"ReferenceAdd":[170],"Description":[171],"ExportRISCitationCitation":[172],"abstractCitation":[174],"referencesMore":[176],"Options":[177],"onFacebookTwitterWechatLinked":[179],"InRedditEmail":[180],"Other":[181],"access":[182],"optionsGet":[183],"e-Alertsclose":[184],"Get":[185],"e-Alerts":[186]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-05-12T00:00:00"}