{"id":"https://openalex.org/W4244544573","doi":"https://doi.org/10.1201/9781482273557-7","title":"The Molecular Biology of Interferon-13 from Receptor Binding to Transmembrane Signaling","display_name":"The Molecular Biology of Interferon-13 from Receptor Binding to Transmembrane Signaling","publication_year":1997,"publication_date":"1997-01-28","ids":{"openalex":"https://openalex.org/W4244544573","doi":"https://doi.org/10.1201/9781482273557-7"},"language":"en","primary_location":{"id":"doi:10.1201/9781482273557-7","doi":"https://doi.org/10.1201/9781482273557-7","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482273557-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interferon Therapy of Multiple Sclerosis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W3021433939","display_name":"Interferon Therapy of Multiple Sclerosis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076720785","display_name":"Lawrence M. Pfeffer","orcid":"https://orcid.org/0000-0003-2809-1234","observed_orcids":["https://orcid.org/0000-0003-2809-1234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence M. Pfeffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033634773","display_name":"Stefan N. Constantinescu","orcid":"https://orcid.org/0000-0002-8599-2699","observed_orcids":["https://orcid.org/0000-0002-8599-2699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan N. Constantinescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44245142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"19","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.5659999847412109},{"id":"https://openalex.org/keywords/interferon-receptor-binding","display_name":"interferon receptor binding","score":0.7680000066757202},{"id":"https://openalex.org/keywords/transmembrane-signaling","display_name":"transmembrane signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9390000104904175},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.5360000133514404},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9539999961853027},{"id":"https://openalex.org/keywords/interferon-omega","display_name":"interferon omega","score":0.6050000190734863},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.5440000295639038},{"id":"https://openalex.org/keywords/interferon-beta-2","display_name":"interferon-beta 2","score":0.4580000042915344},{"id":"https://openalex.org/keywords/ifnb1","display_name":"IFNB1","score":0.48500001430511475},{"id":"https://openalex.org/keywords/interferon-beta-1a","display_name":"interferon beta-1a","score":0.5870000123977661},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6021623611450195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4920148551464081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4847940504550934},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4614817500114441},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.41869133710861206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38947486877441406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2031048834323883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781482273557-7","doi":"https://doi.org/10.1201/9781482273557-7","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482273557-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interferon Therapy of Multiple Sclerosis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2020544711"],"related_works":["https://openalex.org/W2228244803","https://openalex.org/W4210966460","https://openalex.org/W4251539572","https://openalex.org/W4402297344","https://openalex.org/W1993935340","https://openalex.org/W4252973503","https://openalex.org/W2069442382","https://openalex.org/W4255520358","https://openalex.org/W2400109762","https://openalex.org/W26623278"],"abstract_inverted_index":{"I.":[0],"INTRODUCTION":[1],"Interferons":[2],"(IFNs),":[3],"which":[4],"were":[5],"independently":[6],"discovered":[7],"by":[8,213],"two":[9,95],"groups":[10],"in":[11,124,156,173,192],"the":[12,21,34,42,53,71,159,200,205],"1950s":[13],"(1,2),":[14],"are":[15,101,122,171],"proteins":[16],"capable":[17],"of":[18,24,31,46,52,55,61,70,76,158,176,219],"interfering":[19],"with":[20],"viral":[22,37,127],"infection":[23],"cells.":[25],"Their":[26],"discovery":[27],"culminated":[28],"many":[29,157],"years":[30],"study":[32],"on":[33,137,221],"basis":[35],"for":[36,204],"interference.":[38],"Besides":[39],"antiviral":[40],"activity,":[41],"diverse":[43],"biological":[44,109,167,174,201],"actions":[45],"these":[47],"cytokines":[48],"also":[49],"include":[50,87],"inhibition":[51],"proliferation":[54],"normal":[56],"and":[57,68,80,94,108,112,128,131,150,179],"transformed":[58],"cells,":[59],"regulation":[60],"differentiation,":[62],"host":[63],"responses":[64],"to":[65,126],"various":[66],"pathogens,":[67],"modulation":[69],"immune":[72],"system":[73],"(including":[74],"activation":[75],"natural":[77],"killer":[78],"cells":[79],"macrophages).":[81],"The":[82],"human":[83,138],"type":[84,143,153,177,180,185,195,207],"I":[85,99,154,178,196,208],"IFNs":[86,100,155],"15":[88],"IFN-a":[89],"subtypes,":[90],"one":[91],"IFN-0":[92],"subtype,":[93],"IFN-w":[96],"subtypes.":[97],"Type":[98],"acid":[102],"stable,":[103],"have":[104],"similar":[105,166],"protein":[106],"structure":[107],"activities,":[110],"bind":[111],"transduce":[113],"signals":[114],"through":[115],"a":[116,133,222],"common":[117,134],"multiprotein":[118],"cell":[119],"surface":[120],"receptor,":[121],"induced":[123],"response":[125],"other":[129],"inducers,":[130],"share":[132],"gene":[135],"locus":[136],"chromosome":[139],"9.":[140],"In":[141,198],"contrast,":[142],"II":[144,181,186],"IFN":[145,187,209],"(or":[146],"IFN-y)":[147],"is":[148,188],"acid-labile":[149],"differs":[151],"from":[152],"above":[160],"respects":[161],"except":[162],"that":[163],"it":[164],"shares":[165],"actions.":[168],"However,":[169],"there":[170],"differences":[172],"potency":[175],"IFNs.":[182],"For":[183],"example,":[184],"considered":[189],"more":[190],"active":[191],"immunomodulation":[193],"than":[194],"IFN.":[197],"addition,":[199],"specific":[202],"activities":[203],"different":[206],"subtypes":[210],"can":[211],"vary":[212],"as":[214,216],"much":[215],"three":[217],"orders":[218],"magnitude":[220],"logo":[223],"scale.":[224]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}