{"id":"https://openalex.org/W4244532640","doi":"https://doi.org/10.3410/f.733246456.793563861","title":"Faculty Opinions recommendation of Fixation and spread of somatic mutations in adult human colonic epithelium.","display_name":"Faculty Opinions recommendation of Fixation and spread of somatic mutations in adult human colonic epithelium.","publication_year":2019,"publication_date":"2019-08-13","ids":{"openalex":"https://openalex.org/W4244532640","doi":"https://doi.org/10.3410/f.733246456.793563861"},"language":"en","primary_location":{"id":"doi:10.3410/f.733246456.793563861","doi":"https://doi.org/10.3410/f.733246456.793563861","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.733246456.793563861","pdf_url":"https://facultyopinions.com/download/733246456","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://facultyopinions.com/download/733246456","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037308478","display_name":"Todd G. Nystul","orcid":"https://orcid.org/0000-0002-6250-2394","observed_orcids":["https://orcid.org/0000-0002-6250-2394"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Todd Nystul","raw_affiliation_strings":["Department of Anatomy, University of California, San Francisco, USA"],"raw_orcid":"https://orcid.org/0000-0002-6250-2394","affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037308478"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1656000018119812,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9710000157356262},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.8199999928474426},{"id":"https://openalex.org/keywords/crypt-fission","display_name":"crypt fission","score":0.75},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.4749999940395355},{"id":"https://openalex.org/keywords/mutation-fixation","display_name":"mutation fixation","score":0.652999997138977},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5879999995231628},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.7453554272651672},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5795347094535828},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.49796581268310547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4867870509624481},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4565120041370392},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.338903546333313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2918154299259186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.733246456.793563861","doi":"https://doi.org/10.3410/f.733246456.793563861","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.733246456.793563861","pdf_url":"https://facultyopinions.com/download/733246456","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.733246456.793563861","doi":"https://doi.org/10.3410/f.733246456.793563861","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.733246456.793563861","pdf_url":"https://facultyopinions.com/download/733246456","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7120000123977661}],"study_designs":[],"awards":[{"id":"https://openalex.org/G247567827","display_name":"Fundamental and applied biology of intestinal stem cells.","funder_award_id":"103805","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4900274166","display_name":null,"funder_award_id":"MC_UU_12025","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320274","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93"},{"id":"https://openalex.org/F4320325812","display_name":"Norfolk and Norwich University Hospitals NHS Foundation Trust","ror":"https://ror.org/01wspv808"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"},{"id":"https://openalex.org/F4320337195","display_name":"Cancer Research UK Cambridge Institute, University of Cambridge","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4244532640.pdf","grobid_xml":"https://content.openalex.org/works/W4244532640.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1597336200","https://openalex.org/W1903325699","https://openalex.org/W1965766641","https://openalex.org/W1968969468","https://openalex.org/W1977653087","https://openalex.org/W1984592458","https://openalex.org/W1993288617","https://openalex.org/W2006940358","https://openalex.org/W2010873488","https://openalex.org/W2024018307","https://openalex.org/W2042423362","https://openalex.org/W2048528054","https://openalex.org/W2057030383","https://openalex.org/W2064051662","https://openalex.org/W2065220128","https://openalex.org/W2078346691","https://openalex.org/W2086535578","https://openalex.org/W2095718447","https://openalex.org/W2105248842","https://openalex.org/W2111627225","https://openalex.org/W2124423394","https://openalex.org/W2132548846","https://openalex.org/W2140650872","https://openalex.org/W2150520316","https://openalex.org/W2152660706","https://openalex.org/W2153618863","https://openalex.org/W2158059257","https://openalex.org/W2162756888","https://openalex.org/W2168901267","https://openalex.org/W2171412952","https://openalex.org/W2210259689","https://openalex.org/W2320622343","https://openalex.org/W2397950273","https://openalex.org/W2577537660","https://openalex.org/W2604024577","https://openalex.org/W2617554651","https://openalex.org/W2617612590","https://openalex.org/W2943909983","https://openalex.org/W3210232381","https://openalex.org/W4233608416","https://openalex.org/W4251371078"],"related_works":["https://openalex.org/W2804079254","https://openalex.org/W3002235336","https://openalex.org/W2534098185","https://openalex.org/W3041077677","https://openalex.org/W2124423394","https://openalex.org/W2141180172","https://openalex.org/W4239718058","https://openalex.org/W1974246430","https://openalex.org/W7154717986","https://openalex.org/W3090498396"],"abstract_inverted_index":{"takes":[0],"years":[1],"due":[2],"to":[3],"slow":[4],"stem":[5],"cell":[6],"turnover":[7],"d":[8,17],"Crypt":[9],"fission":[10],"enables":[11],"lateral":[12],"expansion":[13,23],"of":[14],"mutant":[15],"clones":[16],"Biases":[18],"in":[19],"both":[20],"fixation":[21],"and":[22],"increase":[24],"age-related":[25],"pro-oncogenic":[26],"burden":[27]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}