{"id":"https://openalex.org/W4244468619","doi":"https://doi.org/10.1016/j.juro.2018.02.615","title":"PD10-05 PHASE 3 STUDY OF INTERMITTENT MONOTHERAPY VERSUS CONTINUOUS COMBINED ANDROGEN DEPRIVATION","display_name":"PD10-05 PHASE 3 STUDY OF INTERMITTENT MONOTHERAPY VERSUS CONTINUOUS COMBINED ANDROGEN DEPRIVATION","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W4244468619","doi":"https://doi.org/10.1016/j.juro.2018.02.615"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2018.02.615","doi":"https://doi.org/10.1016/j.juro.2018.02.615","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2018.02.615","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054920808","display_name":"Fernando Calais da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Calais da Silva Junior","raw_affiliation_strings":["Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021059207","display_name":"Fernando Calais da Silva Senior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Calais da Silva Senior","raw_affiliation_strings":["Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046156442","display_name":"Frederico Bastos Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-9825-9007","observed_orcids":["https://orcid.org/0000-0002-9825-9007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederico Gon\u00e7alves","raw_affiliation_strings":["Bratislava, Slovakia (Slovak Republic)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bratislava, Slovakia (Slovak Republic)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040544258","display_name":"Jan Kliment","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Kliment","raw_affiliation_strings":["Martin, Slovakia (Slovak Republic)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin, Slovakia (Slovak Republic)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102153659","display_name":"Am\u00e9rico Santos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Am\u00e9rico Santos","raw_affiliation_strings":["Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Braga, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060499374","display_name":"Spiros Pastidis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spiros Pastidis","raw_affiliation_strings":["Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109246978","display_name":"Antonio Queimadelos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Queimadelos","raw_affiliation_strings":["Santiago Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santiago Compostela, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103549044","display_name":"Chris Robertson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Robertson","raw_affiliation_strings":["Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glasgow, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25105588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"199","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermittent-androgen-deprivation-therapy","display_name":"intermittent androgen deprivation therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/continuous-androgen-deprivation-therapy","display_name":"continuous androgen deprivation therapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/ciproterone-acetate","display_name":"ciproterone acetate","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cyproterone-acetate","display_name":"cyproterone acetate","score":0.6079999804496765},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.5809999704360962},{"id":"https://openalex.org/keywords/follow-up-outcomes","display_name":"follow-up outcomes","score":0.5519999861717224},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7795462608337402},{"id":"https://openalex.org/C2776288485","wikidata":"https://www.wikidata.org/wiki/Q5018342","display_name":"Calais","level":2,"score":0.5810793042182922},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3321489691734314},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2018.02.615","doi":"https://doi.org/10.1016/j.juro.2018.02.615","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2018.02.615","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4230582915","https://openalex.org/W2793406092","https://openalex.org/W4237577464","https://openalex.org/W2242131855","https://openalex.org/W4231173328","https://openalex.org/W1982166321","https://openalex.org/W2244275612","https://openalex.org/W2915045265","https://openalex.org/W1933794219","https://openalex.org/W2037416732"],"abstract_inverted_index":{"You":[0],"have":[1,338,386,435,486,516,541,641,669],"accessJournal":[2],"of":[3,193,195,204,243,275,313,336,356,379,459,467,490,506,520,545,575,590,632,673],"UrologyProstate":[4],"Cancer:":[5],"Advanced":[6],"(including":[7],"Drug":[8],"Therapy)":[9],"I1":[10],"Apr":[11],"2018PD10-05":[12],"PHASE":[13],"3":[14,285],"STUDY":[15],"OF":[16],"INTERMITTENT":[17],"MONOTHERAPY":[18],"VERSUS":[19],"CONTINUOUS":[20],"COMBINED":[21],"ANDROGEN":[22],"DEPRIVATION":[23],"Fernando":[24,29,47,62,694,704],"Calais":[25,30,48,52,63,67,695,705],"da":[26,31,49,53,64,68,696,706],"Silva":[27,32,50,54,65,69,697,707],"Junior,":[28],"Senior,":[33],"Frederico":[34,77,714],"Gon\u00e7alves,":[35],"Jan":[36,86,721],"Kliment,":[37],"Am\u00e9rico":[38,95,728],"Santos,":[39],"Spiros":[40,104,735],"Pastidis,":[41],"Antonio":[42,113,742],"Queimadelos,":[43],"and":[44,122,187,190,237,278,300,320,373,393,400,409,420,432,451,465,474,497,539,564,603,613],"Chris":[45,123,749],"Robertson":[46,125,750],"JuniorFernando":[51],"Junior":[55,698],"More":[56,71,80,89,98,107,116,126,699,709,716,723,730,737,744,751],"articles":[57,72,81,90,99,108,117,127,700,710,717,724,731,738,745,752],"by":[58,73,82,91,100,109,118,128,650,701,711,718,725,732,739,746,753],"this":[59,74,83,92,101,110,119,129,702,712,719,726,733,740,747,754],"author":[60,75,84,93,102,111,120,130,703,713,720,727,734,741,748,755],",":[61,76,85,94,103,112,121],"SeniorFernando":[66],"Senior":[70,708],"Gon\u00e7alvesFrederico":[78],"Gon\u00e7alves":[79,715],"KlimentJan":[87],"Kliment":[88,722],"SantosAm\u00e9rico":[96],"Santos":[97,729],"PastidisSpiros":[105],"Pastidis":[106,736],"QueimadelosAntonio":[114],"Queimadelos":[115,743],"RobertsonChris":[124],"View":[131],"All":[132,757],"Author":[133],"Informationhttps://doi.org/10.1016/j.juro.2018.02.615AboutPDF":[134],"ToolsAdd":[135],"to":[136,164,201,210,220,333,462,527,536,548,578,587,622,640,666,677],"favoritesDownload":[137],"CitationsTrack":[138],"CitationsPermissionsReprints":[139],"ShareFacebookTwitterLinked":[140],"InEmail":[141],"INTRODUCTION":[142],"AND":[143],"OBJECTIVES":[144],"Intermittent":[145,218,371,569,618,667],"androgen":[146,181],"deprivation":[147,182],"therapy":[148,208,277,299,302,372,464,570,580,619,647,668],"can":[149,615],"only":[150],"be":[151],"appropriately":[152],"evaluated":[153],"in":[154,206,600,628,659],"a":[155,213,225,241,310,339,354,500,517,572,588,637,670,674,678],"randomized":[156,461,665],"fashion.":[157],"We":[158,593],"present":[159],"updated":[160],"follow":[161,348],"up":[162,349,438,583],"results,":[163],"Sept":[165],"2017,":[166],"from":[167,331,388,396,403,412],"the":[168,175,288,596,601],"SEUG":[169],"9901":[170],"Phase":[171],"III":[172],"study":[173,198],"comparing":[174],"intermittent":[176,207,301],"monotherapy":[177],"with":[178,309,353,444,508],"continuous":[179,298],"combined":[180],"using":[183],"an":[184,487,503,542],"LHRH":[185,265],"analogue":[186],"ciproterone":[188],"acetate":[189],"associated":[191],"components":[192],"quality":[194],"life.":[196],"The":[197,323,346],"was":[199],"powered":[200],"establish":[202],"equivalence":[203,230],"mortality":[205],"compared":[209,219,526,577],"continuous.":[211],"Assuming":[212],"HR":[214],"=":[215,235,239],"1.21":[216],"for":[217,229,262,439,446,453,482,502,561],"Continuous,":[221],"then":[222],"based":[223],"on":[224,370,375,469,568,645],"one-sided":[226],"logrank":[227],"test":[228],"at":[231,326,344,440,447,454,476,595],"error":[232],"rates":[233],"alpha":[234],"0.05":[236],"beta":[238],"0.20,":[240],"total":[242,249,378],"658":[244,380,597],"deaths":[245,598],"were":[246,315,361],"required.":[247],"This":[248],"has":[250,584],"now":[251],"been":[252,436,585],"reached.":[253],"METHODS":[254],"Patients":[255],"received":[256],"Cyproterone":[257],"Acetate":[258],"(200":[259],"mg/day)":[260],"administered":[261],"2":[263,273,538],"weeks.":[264],"agonist":[266],"(1":[267],"monthly":[268],"depot":[269],"injection)":[270],"started":[271],"after":[272],"weeks":[274,282],"lead-in":[276],"given":[279],"every":[280],"4":[281,292,540],"thereafter.":[283],"After":[284],"months":[286],"when":[287],"PSA":[289,312,325,340,473,534,551,563],"is":[290,328,350,425,499,605,611,620,636,656],"below":[291],"ng/ml,":[293],"patients":[294,337,360,385,434,485,567],"where":[295],"randomised":[296],"between":[297,317,537],"CPA":[303],"(300":[304],"mg/day).":[305],"RESULTS":[306],"1045":[307],"men":[308,513,528],"median":[311,324,355],"15.9ng/ml":[314],"registered":[316],"Oct.":[318],"1999":[319],"Sept.":[321],"2007.":[322],"randomisation":[327],"1.0ng/ml":[329],"ranging":[330],"0.1":[332],"9.":[334],"49.2%":[335],"less":[341],"than":[342,365],"1ng/ml":[343],"randomisation.":[345],"maximum":[347,589],"17.2":[351],"years":[352,367,427,450,457],"5.8":[357],"years.":[358,592],"214":[359],"still":[362],"alive":[363],"more":[364],"10":[366],"following":[368],"randomization,107":[369],"107":[374],"Continuous.":[376,623],"A":[377],"(331":[381],"Intermittent,":[382],"327":[383],"Continuous)":[384],"died;208":[387],"prostate":[389,660],"cancer":[390,661],"(106":[391],"Int.":[392,399,408,419,463],"102":[394],"Cont.),275":[395],"CVD":[397],"(131":[398],"144":[401],"Cont.),46":[402],"other":[404],"metastatic":[405,565],"disease":[406],"(29":[407],"17":[410,591],"Cont.)129":[411],"Other":[413],"Causes,":[414],"including":[415],"unknown":[416],"cause":[417,629],"(65":[418],"64":[421],"Cont.).":[422,470],"Median":[423],"survival":[424,610,644],"6.5":[426],"(95%":[428,522],"CI":[429,494,523,557],"6.0,":[430],"6.9)":[431],"536":[433],"followed":[437],"least":[441,448,455],"five":[442],"years,":[443],"363":[445],"7":[449],"117":[452],"12":[456],"(13%":[458],"those":[460,468,549,664],"13%":[466],"Metastatic":[471],"status,":[472,566],"age":[475,510],"randomization":[477],"are":[478,594,625],"all":[479],"prognostic":[480],"factors":[481],"survival.":[483],"M1":[484],"increased":[488,543],"risk":[489],"dying":[491,546],"(HR=1.64,":[492],"95%":[493,556],"1.28,":[495],"2.09)":[496],"there":[498,604,635],"trend":[501],"increasing":[504,509],"hazard":[505,518,544,574,672],"death":[507,576,633,675],"so":[511],"that":[512,608,617],"aged":[514,529],"75+":[515],"ratio":[519],"1.79":[521],"1.21,":[524],"2.66)":[525],"under":[530],"60.":[531],"Men":[532],"whose":[533,550],"falls":[535,552],"relative":[547],"bellow":[553],"0.5":[554],"(HR=1.86,":[555],"1.52,":[558],"2.27).":[559],"Adjusting":[560],"Age,":[562],"had":[571],"reduced":[573],"Continuous":[579,646],"CONCLUSIONS":[581],"Follow":[582],"extended":[586],"specified":[599],"protocol":[602],"no":[606,626,657],"evidence":[607],"overall":[609],"poorer":[612,643],"we":[614],"conclude":[616],"equivalent":[621],"There":[624,655],"differences":[627],"specific":[630],"hazards":[631],"though":[634,663],"slight":[638],"tendency":[639],"slightly":[642],"driven":[648],"largely":[649],"elevated":[651],"cardio":[652],"vascular":[653],"deaths.":[654],"difference":[658],"deaths,":[662],"higher":[671],"due":[676],"non-prostate":[679],"cancer.":[680],"\u00a9":[681],"2018FiguresReferencesRelatedDetails":[682],"Volume":[683],"199Issue":[684],"4SApril":[685],"2018Page:":[686],"e229":[687],"Advertisement":[688,758,759],"Copyright":[689],"&":[690],"Permissions\u00a9":[691],"2018MetricsAuthor":[692],"Information":[693],"Expand":[756],"PDF":[760],"downloadLoading":[761],"...":[762]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}