{"id":"https://openalex.org/W4244463436","doi":"https://doi.org/10.21203/rs.3.rs-147112/v1","title":"Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice","display_name":"Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice","publication_year":2020,"publication_date":"2020-11-30","ids":{"openalex":"https://openalex.org/W4244463436","doi":"https://doi.org/10.21203/rs.3.rs-147112/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-147112/v1","doi":"https://doi.org/10.21203/rs.3.rs-147112/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-147112/v1","pdf_url":"https://www.researchsquare.com/article/rs-147112/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-147112/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085610448","display_name":"Shihui Sun","orcid":"https://orcid.org/0000-0002-2623-9939","observed_orcids":["https://orcid.org/0000-0002-2623-9939"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihui Sun","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594858","display_name":"Lei He","orcid":"https://orcid.org/0000-0001-6955-0121","observed_orcids":["https://orcid.org/0000-0001-6955-0121"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei He","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046932686","display_name":"Zhongpeng Zhao","orcid":"https://orcid.org/0000-0002-9147-6252","observed_orcids":["https://orcid.org/0000-0002-9147-6252"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongpeng Zhao","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101978595","display_name":"Hongjing Gu","orcid":"https://orcid.org/0000-0002-6701-5798","observed_orcids":["https://orcid.org/0000-0002-6701-5798"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjing Gu","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001961475","display_name":"Xin De Fang","orcid":"https://orcid.org/0000-0002-4118-7815","observed_orcids":["https://orcid.org/0000-0002-4118-7815"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Fang","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing, 100022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing, 100022, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762668","display_name":"Tiecheng Wang","orcid":"https://orcid.org/0000-0002-0971-5569","observed_orcids":["https://orcid.org/0000-0002-0971-5569"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiecheng Wang","raw_affiliation_strings":["Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001852042","display_name":"Xiaolan Yang","orcid":"https://orcid.org/0000-0002-6903-5995","observed_orcids":["https://orcid.org/0000-0002-6903-5995"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolan Yang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064124954","display_name":"Shaolong Chen","orcid":"https://orcid.org/0009-0001-4734-2169","observed_orcids":["https://orcid.org/0009-0001-4734-2169"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaolong Chen","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005132315","display_name":"Yong\u2010Qiang Deng","orcid":"https://orcid.org/0000-0002-2306-1039","observed_orcids":["https://orcid.org/0000-0002-2306-1039"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqiang Deng","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019810","display_name":"Jiangfan Li","orcid":"https://orcid.org/0000-0001-6884-104X","observed_orcids":["https://orcid.org/0000-0001-6884-104X"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangfan Li","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107499226","display_name":"Jian Zhao","orcid":"https://orcid.org/0000-0002-8567-5925","observed_orcids":["https://orcid.org/0000-0002-8567-5925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Zhao","raw_affiliation_strings":["JOINN Biologics, Beijing, 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOINN Biologics, Beijing, 100000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420708","display_name":"Liang Li","orcid":"https://orcid.org/0000-0003-1001-7837","observed_orcids":["https://orcid.org/0000-0003-1001-7837"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Li","raw_affiliation_strings":["Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072693564","display_name":"Xinwang Li","orcid":"https://orcid.org/0000-0002-5184-3636","observed_orcids":["https://orcid.org/0000-0002-5184-3636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinwang Li","raw_affiliation_strings":["ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","institution_ids":[]},{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng He","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing, 100022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing, 100022, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103666070","display_name":"Ge Li","orcid":"https://orcid.org/0000-0002-6575-8969","observed_orcids":["https://orcid.org/0000-0002-6575-8969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ge Li","raw_affiliation_strings":["Institute of Military Cognition and Brain Science, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Cognition and Brain Science, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348616","display_name":"Hao Li","orcid":"https://orcid.org/0000-0002-6280-267X","observed_orcids":["https://orcid.org/0000-0002-6280-267X"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Li","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059804178","display_name":"Yuee Zhao","orcid":"https://orcid.org/0000-0003-0136-006X","observed_orcids":["https://orcid.org/0000-0003-0136-006X","https://orcid.org/0000-0001-9114-6811"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuee Zhao","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026629331","display_name":"Chunrun Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunrun Gao","raw_affiliation_strings":["ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","institution_ids":[]},{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011359734","display_name":"Xiaolin Lang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolin Lang","raw_affiliation_strings":["JOINN Biologics, Beijing, 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOINN Biologics, Beijing, 100000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327826","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0001-7678-0785","observed_orcids":["https://orcid.org/0000-0001-7678-0785","https://orcid.org/0000-0001-7555-5244","https://orcid.org/0000-0001-7467-6060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","institution_ids":[]},{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038620286","display_name":"Guoqiang Fei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoqiang Fei","raw_affiliation_strings":["ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","institution_ids":[]},{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711754","display_name":"Yan Li","orcid":"https://orcid.org/0000-0001-7609-2683","observed_orcids":["https://orcid.org/0000-0001-7609-2683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Institute of Military Cognition and Brain Science, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Cognition and Brain Science, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013967966","display_name":"Shusheng Geng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shusheng Geng","raw_affiliation_strings":["JOINN Biologics, Beijing, 100000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOINN Biologics, Beijing, 100000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101654124","display_name":"Yuwei Gao","orcid":"https://orcid.org/0000-0002-8278-2418","observed_orcids":["https://orcid.org/0000-0002-8278-2418","https://orcid.org/0009-0007-3221-9495"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuwei Gao","raw_affiliation_strings":["Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun 130122, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101981458","display_name":"Wenjin Wei","orcid":"https://orcid.org/0009-0006-5226-742X","observed_orcids":["https://orcid.org/0009-0006-5226-742X","https://orcid.org/0000-0002-8479-3719"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wenjin Wei","raw_affiliation_strings":["ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 300402, China","institution_ids":[]},{"raw_affiliation_string":"ZHONGYIANKE Biotech Co., LTD., Tianjin, 30002, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100959019","display_name":"Zhongyu Hu","orcid":"https://orcid.org/0000-0001-5781-971X","observed_orcids":["https://orcid.org/0000-0001-5781-971X","https://orcid.org/0009-0005-1935-0371"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongyu Hu","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing, 100022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing, 100022, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886909","display_name":"Gencheng Han","orcid":"https://orcid.org/0000-0003-1408-878X","observed_orcids":["https://orcid.org/0000-0003-1408-878X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gencheng Han","raw_affiliation_strings":["Institute of Military Cognition and Brain Science, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Military Cognition and Brain Science, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101013195","display_name":"Yansong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yansong Sun","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 0007, China","institution_ids":["https://openalex.org/I4405260518"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100959019","https://openalex.org/A5101013195","https://openalex.org/A5101654124","https://openalex.org/A5101886909","https://openalex.org/A5101981458"],"corresponding_institution_ids":["https://openalex.org/I2802541053","https://openalex.org/I4210136676","https://openalex.org/I4405260518"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.9789999723434448},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/fc-fusion-protein","display_name":"Fc fusion protein","score":0.7730000019073486},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.859000027179718},{"id":"https://openalex.org/keywords/ace2-transgenic-mice","display_name":"ACE2 transgenic mice","score":0.8870000243186951},{"id":"https://openalex.org/keywords/vaccine-protection","display_name":"vaccine protection","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7701669931411743},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6343364715576172},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.623120903968811},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5796527862548828},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5750059485435486},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.49211639165878296},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.480551540851593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4736137092113495},{"id":"https://openalex.org/C2910188402","wikidata":"https://www.wikidata.org/wiki/Q85438966","display_name":"Severe acute respiratory syndrome coronavirus","level":5,"score":0.4645637571811676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45682293176651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4549205005168915},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.4118880033493042},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1756829023361206},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.12029388546943665},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1196526288986206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0808866024017334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07962372899055481}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21203/rs.3.rs-147112/v1","doi":"https://doi.org/10.21203/rs.3.rs-147112/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-147112/v1","pdf_url":"https://www.researchsquare.com/article/rs-147112/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.1101/2020.11.29.402339","doi":"https://doi.org/10.1101/2020.11.29.402339","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.11.29.402339","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/11/30/2020.11.29.402339.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-147112/v1","doi":"https://doi.org/10.21203/rs.3.rs-147112/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-147112/v1","pdf_url":"https://www.researchsquare.com/article/rs-147112/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1408870807","display_name":null,"funder_award_id":"2020YFC0860100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6015095389","display_name":null,"funder_award_id":"82041006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4244463436.pdf","grobid_xml":"https://content.openalex.org/works/W4244463436.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1502149713","https://openalex.org/W1506151812","https://openalex.org/W1835648969","https://openalex.org/W1973873487","https://openalex.org/W1998952429","https://openalex.org/W2049845957","https://openalex.org/W2052669763","https://openalex.org/W2061483083","https://openalex.org/W2074969682","https://openalex.org/W2081861008","https://openalex.org/W2106921881","https://openalex.org/W2111201258","https://openalex.org/W2131094833","https://openalex.org/W2141247392","https://openalex.org/W2167775515","https://openalex.org/W2170564629","https://openalex.org/W2324542890","https://openalex.org/W2339647820","https://openalex.org/W2573687447","https://openalex.org/W2603215472","https://openalex.org/W2609522093","https://openalex.org/W2757148502","https://openalex.org/W2789954133","https://openalex.org/W2802659015","https://openalex.org/W2915930679","https://openalex.org/W3003280167","https://openalex.org/W3012650581","https://openalex.org/W3012756997","https://openalex.org/W3016137283","https://openalex.org/W3017129059","https://openalex.org/W3019838949","https://openalex.org/W3023494626","https://openalex.org/W3037923073","https://openalex.org/W3039901154","https://openalex.org/W3043991892","https://openalex.org/W3045578670","https://openalex.org/W3045870925","https://openalex.org/W3048827124","https://openalex.org/W3069586704","https://openalex.org/W3082102108","https://openalex.org/W3100347672","https://openalex.org/W6669274135","https://openalex.org/W6781173592"],"related_works":["https://openalex.org/W3137864390","https://openalex.org/W3116570842","https://openalex.org/W3106917004","https://openalex.org/W3201739341","https://openalex.org/W3036780611","https://openalex.org/W4396955555","https://openalex.org/W3045578670","https://openalex.org/W3176810634","https://openalex.org/W3214044279","https://openalex.org/W4307496697"],"abstract_inverted_index":{"Abstract":[0],"The":[1,13,93],"severe":[2],"acute":[3],"respiratory":[4],"syndrome":[5],"coronavirus-2":[6],"(SARS-CoV-2)":[7],"continues":[8],"to":[9,24],"infect":[10],"people":[11],"globally.":[12],"increased":[14],"COVID-19":[15],"cases":[16],"and":[17,27,45,88,120],"no":[18],"licensed":[19],"vaccines":[20,29,34,138],"highlight":[21],"the":[22,62,72],"need":[23],"develop":[25],"safe":[26],"effective":[28],"against":[30],"SARS-CoV-2":[31,67,81,128,137,163],"infection.":[32],"Multiple":[33],"candidates":[35],"are":[36],"under":[37],"pre-clinical":[38],"or":[39,116,123],"clinical":[40,134,153],"trails":[41],"with":[42,61,71],"different":[43],"strengths":[44],"weaknesses.":[46],"Here":[47],"we":[48],"developed":[49],"a":[50,55,105,162],"pilot":[51],"scale":[52],"production":[53],"of":[54,66,75,136,161],"recombinant":[56],"subunit":[57,165],"vaccine":[58],"(RBD-Fc":[59],"Vacc)":[60],"Receptor":[63],"Binding":[64],"Domain":[65],"S":[68],"protein":[69],"fused":[70],"Fc":[73],"domain":[74],"human":[76,89,152],"IgG1.":[77],"RBD-Fc":[78,141,164],"Vacc":[79,142],"induced":[80,95],"specific":[82],"neutralizing":[83,107],"antibodies":[84,94],"in":[85,96,147],"non-human":[86],"primates":[87],"ACE2":[90],"transgenic":[91],"mice.":[92],"macaca":[97],"fascicularis":[98,114],"neutralized":[99],"three":[100],"divergent":[101],"SARS-CoV2":[102],"strains,":[103],"suggesting":[104],"broader":[106],"ability.":[108],"Three":[109],"times":[110],"immunizations":[111],"protected":[112],"Macaca":[113],"(20ug":[115],"40ug":[117],"per":[118,125],"dose)":[119,126],"mice":[121],"(10ug":[122],"20ug":[124],"from":[127],"infection":[129],"respectively.":[130],"These":[131],"data":[132],"support":[133],"development":[135],"for":[139],"humans.":[140],"is":[143],"currently":[144],"being":[145],"assessed":[146],"randomized":[148],"controlled":[149],"phase":[150],"1/II":[151],"trails.":[154],"Summary":[155],"This":[156],"study":[157],"confirms":[158],"protective":[159],"efficacy":[160],"vaccine.":[166]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}