{"id":"https://openalex.org/W4244460059","doi":"https://doi.org/10.1002/0471142700.nc0440s42","title":"Synthesis of Glycerol Nucleic Acid (GNA) Phosphoramidite Monomers and Oligonucleotide Polymers","display_name":"Synthesis of Glycerol Nucleic Acid (GNA) Phosphoramidite Monomers and Oligonucleotide Polymers","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W4244460059","doi":"https://doi.org/10.1002/0471142700.nc0440s42","pmid":"https://pubmed.ncbi.nlm.nih.gov/20827716"},"language":"en","primary_location":{"id":"doi:10.1002/0471142700.nc0440s42","doi":"https://doi.org/10.1002/0471142700.nc0440s42","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142700.nc0440s42","pdf_url":null,"source":{"id":"https://openalex.org/S4210220840","display_name":"Current Protocols in Nucleic Acid Chemistry","issn_l":"1934-9270","issn":["1934-9270","1934-9289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-40"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Nucleic Acid Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101757160","display_name":"Su Zhang","orcid":"https://orcid.org/0000-0001-5962-1758","observed_orcids":["https://orcid.org/0000-0001-5962-1758"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Zhang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona","The Biodesign Institute at Arizona State University, Tempe, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"The Biodesign Institute at Arizona State University, Tempe, Arizona","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081890628","display_name":"John Charles Chaput","orcid":"https://orcid.org/0000-0003-1393-135X","observed_orcids":["https://orcid.org/0000-0003-1393-135X"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Chaput","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona","The Biodesign Institute at Arizona State University, Tempe, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"The Biodesign Institute at Arizona State University, Tempe, Arizona","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":0.1302,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53081802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"1","first_page":"Unit4.40","last_page":"Unit4.40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gna","display_name":"GNA","score":0.7239999771118164},{"id":"https://openalex.org/keywords/phosphoramidite-monomers","display_name":"phosphoramidite monomers","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oligonucleotide-synthesis","display_name":"oligonucleotide synthesis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dna-nanotechnology","display_name":"DNA nanotechnology","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2776043002","wikidata":"https://www.wikidata.org/wiki/Q2687447","display_name":"Phosphoramidite","level":4,"score":0.9145904779434204},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.8878260254859924},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7652102708816528},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6708540916442871},{"id":"https://openalex.org/C25862648","wikidata":"https://www.wikidata.org/wiki/Q15057699","display_name":"Nucleic acid analogue","level":5,"score":0.6267465949058533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6225229501724243},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5607802867889404},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5100329518318176},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.4302579164505005},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4011901021003723},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38910621404647827},{"id":"https://openalex.org/C54871578","wikidata":"https://www.wikidata.org/wiki/Q2074275","display_name":"Nucleic acid thermodynamics","level":4,"score":0.369326651096344},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3479465842247009},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3392159938812256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2395346760749817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10098758339881897},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.07256779074668884}],"mesh":[{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/0471142700.nc0440s42","doi":"https://doi.org/10.1002/0471142700.nc0440s42","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142700.nc0440s42","pdf_url":null,"source":{"id":"https://openalex.org/S4210220840","display_name":"Current Protocols in Nucleic Acid Chemistry","issn_l":"1934-9270","issn":["1934-9270","1934-9289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-40"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Nucleic Acid Chemistry","raw_type":"journal-article"},{"id":"pmid:20827716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20827716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protocols in nucleic acid chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1970131031","https://openalex.org/W1974231617","https://openalex.org/W2002999950","https://openalex.org/W2005999232","https://openalex.org/W2008819037","https://openalex.org/W2012991294","https://openalex.org/W2024841149","https://openalex.org/W2026198319","https://openalex.org/W2035195140","https://openalex.org/W2042037994","https://openalex.org/W2042883138","https://openalex.org/W2066832591","https://openalex.org/W2152763806","https://openalex.org/W2952007996"],"related_works":["https://openalex.org/W2002999950","https://openalex.org/W1519174653","https://openalex.org/W2035195140","https://openalex.org/W2024841149","https://openalex.org/W2089865129","https://openalex.org/W2083853178","https://openalex.org/W2042037994","https://openalex.org/W2020333977","https://openalex.org/W2018617183","https://openalex.org/W7097793337"],"abstract_inverted_index":{"This":[0],"unit":[1],"describes":[2],"a":[3,50],"straightforward":[4],"method":[5],"for":[6],"preparing":[7],"glycerol":[8],"nucleic":[9,26,51,83],"acid":[10,27,52,84],"(GNA)":[11],"phosphoramidite":[12,20],"monomers":[13],"and":[14,68,76,94],"oligonucleotide":[15],"polymers":[16],"using":[17],"standard":[18],"cyanoethyl":[19],"chemistry.":[21],"GNA":[22,44],"is":[23],"an":[24,31],"unnatural":[25,103],"analog":[28],"composed":[29],"of":[30,73,81,92],"acyclic":[32],"three-carbon":[33],"sugar-phosphate":[34],"backbone":[35],"that":[36,98],"contains":[37],"one":[38],"stereogenic":[39],"center":[40],"per":[41],"repeating":[42],"unit.":[43],"has":[45],"attracted":[46],"significant":[47],"attention":[48],"as":[49,102],"derivative":[53],"due":[54],"to":[55,59,88],"its":[56],"unique":[57],"ability":[58],"form":[60],"stable":[61],"Watson-Crick":[62],"anti-parallel":[63],"duplex":[64],"structures":[65,97],"with":[66],"thermal":[67],"thermodynamic":[69],"stabilities":[70],"rivaling":[71],"those":[72],"natural":[74],"DNA":[75,107],"RNA.":[77],"The":[78],"chemical":[79],"simplicity":[80],"this":[82],"structure":[85],"provides":[86],"access":[87],"enantiomerically":[89],"pure":[90],"forms":[91],"right-":[93],"left-handed":[95],"helical":[96],"can":[99],"be":[100],"used":[101],"building":[104],"blocks":[105],"in":[106],"nanotechnology.":[108]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}
