{"id":"https://openalex.org/W4244272181","doi":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","title":"Efic\u00e1cia e seguran\u00e7a do pamidronato para o tratamento de osteoporose na p\u00f3s-menopausa","display_name":"Efic\u00e1cia e seguran\u00e7a do pamidronato para o tratamento de osteoporose na p\u00f3s-menopausa","publication_year":2018,"publication_date":"2018-02-28","ids":{"openalex":"https://openalex.org/W4244272181","doi":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27"},"language":"pt","primary_location":{"id":"doi:10.22563/2525-7323.2016.v1.s1.p.27","doi":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","is_oa":true,"landing_page_url":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","pdf_url":"https://ojs.jaff.org.br/ojs/index.php/jaff/article/download/176/233","source":{"id":"https://openalex.org/S4210196108","display_name":"Jornal de Assist\u00eancia Farmac\u00eautica e Farmacoeconomia","issn_l":"2525-7323","issn":["2525-7323","2525-5010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JORNAL DE ASSIST\u00caNCIA FARMAC\u00caUTICA E FARMACOECONOMIA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ojs.jaff.org.br/ojs/index.php/jaff/article/download/176/233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041236731","display_name":"Rosiane Mateus Augusto","orcid":"https://orcid.org/0000-0001-7365-824X","observed_orcids":["https://orcid.org/0000-0001-7365-824X"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210161245","display_name":"Cochrane Canada","ror":"https://ror.org/05cf80b72","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"id":"https://openalex.org/I72054575","display_name":"Cochrane","ror":"https://ror.org/00dbkrq51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I72054575"]}],"countries":["BR","CA","GB"],"is_corresponding":false,"raw_author_name":"Rosiane Mateus Augusto","raw_affiliation_strings":["julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","osteoporose na p\u00f3s-menopausa","osteoporose, entretanto foi inclu\u00eddo no arsenal","tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente"],"raw_orcid":"https://orcid.org/0000-0001-7365-824X","affiliations":[{"raw_affiliation_string":"julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","institution_ids":[]},{"raw_affiliation_string":"The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","institution_ids":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","institution_ids":[]},{"raw_affiliation_string":"de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","institution_ids":[]},{"raw_affiliation_string":"osteoporose na p\u00f3s-menopausa","institution_ids":[]},{"raw_affiliation_string":"osteoporose, entretanto foi inclu\u00eddo no arsenal","institution_ids":[]},{"raw_affiliation_string":"tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082283472","display_name":"Andr\u00e9 Soares Santos","orcid":"https://orcid.org/0000-0002-2856-7100","observed_orcids":["https://orcid.org/0000-0002-2856-7100"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210161245","display_name":"Cochrane Canada","ror":"https://ror.org/05cf80b72","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"id":"https://openalex.org/I72054575","display_name":"Cochrane","ror":"https://ror.org/00dbkrq51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I72054575"]}],"countries":["BR","CA","GB"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Soares Santos","raw_affiliation_strings":["julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","osteoporose na p\u00f3s-menopausa","osteoporose, entretanto foi inclu\u00eddo no arsenal","tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente"],"raw_orcid":"https://orcid.org/0000-0002-2856-7100","affiliations":[{"raw_affiliation_string":"julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","institution_ids":[]},{"raw_affiliation_string":"The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","institution_ids":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","institution_ids":[]},{"raw_affiliation_string":"de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","institution_ids":[]},{"raw_affiliation_string":"osteoporose na p\u00f3s-menopausa","institution_ids":[]},{"raw_affiliation_string":"osteoporose, entretanto foi inclu\u00eddo no arsenal","institution_ids":[]},{"raw_affiliation_string":"tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026220541","display_name":"Cristina Mariano Ruas","orcid":"https://orcid.org/0000-0003-0275-8416","observed_orcids":["https://orcid.org/0000-0003-0275-8416"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210161245","display_name":"Cochrane Canada","ror":"https://ror.org/05cf80b72","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"id":"https://openalex.org/I72054575","display_name":"Cochrane","ror":"https://ror.org/00dbkrq51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I72054575"]}],"countries":["BR","CA","GB"],"is_corresponding":false,"raw_author_name":"Cristina Mariano Ruas Brand\u00e3o","raw_affiliation_strings":["julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","osteoporose na p\u00f3s-menopausa","osteoporose, entretanto foi inclu\u00eddo no arsenal","tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente"],"raw_orcid":"https://orcid.org/0000-0003-0275-8416","affiliations":[{"raw_affiliation_string":"julgamento sobre a randomiza\u00e7\u00e3o e sigilo da aloca\u00e7\u00e3o. Os estudos","institution_ids":[]},{"raw_affiliation_string":"The Cochrane Library e Lilacs (via BVS). Busca complementar em peri\u00f3dicos, bases de teses e disserta\u00e7\u00f5es e resumos de congressos foi realizada para garantir a inclus\u00e3o de todos os estudos de interesse. Foram inclu\u00eddos ensaios cl\u00ednicos randomizados que avaliaram","institution_ids":["https://openalex.org/I4210161245","https://openalex.org/I72054575"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais Introdu\u00e7\u00e3o: A osteoporose \u00e9 uma doen\u00e7a osteoesquel\u00e9tica sist\u00eamica caracterizada por diminui\u00e7\u00e3o da densidade mineral","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"avaliada pela escala de Risco de Vi\u00e9s da Colabora\u00e7\u00e3o Cochrane. Resultados: Foram inclu\u00eddos","institution_ids":[]},{"raw_affiliation_string":"de medicamentos n\u00e3o \u00e9 indicada. Observa-se a necessidade de realiza\u00e7\u00e3o de estudos maiores e melhores sobre o uso do pamidronato em rela\u00e7\u00e3o a comparadores ativos usados","institution_ids":[]},{"raw_affiliation_string":"osteoporose na p\u00f3s-menopausa","institution_ids":[]},{"raw_affiliation_string":"osteoporose, entretanto foi inclu\u00eddo no arsenal","institution_ids":[]},{"raw_affiliation_string":"tratamento recomendado de forma que n\u00e3o se pode avaliar objetivamente","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"s. 1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.4909999966621399},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.6600000262260437},{"id":"https://openalex.org/keywords/osteoclast-activity","display_name":"osteoclast activity","score":0.4480000138282776},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.6930000185966492},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.5460000038146973},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.42500001192092896},{"id":"https://openalex.org/keywords/risk-of-bias-assessment","display_name":"risk of bias assessment","score":0.7889999747276306},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.3840000033378601},{"id":"https://openalex.org/keywords/follow-up-duration","display_name":"follow-up duration","score":0.5189999938011169},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3310000002384186},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8748482465744019},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5353029370307922},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4969804584980011},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.24232766032218933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19404888153076172}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22563/2525-7323.2016.v1.s1.p.27","doi":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","is_oa":true,"landing_page_url":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","pdf_url":"https://ojs.jaff.org.br/ojs/index.php/jaff/article/download/176/233","source":{"id":"https://openalex.org/S4210196108","display_name":"Jornal de Assist\u00eancia Farmac\u00eautica e Farmacoeconomia","issn_l":"2525-7323","issn":["2525-7323","2525-5010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JORNAL DE ASSIST\u00caNCIA FARMAC\u00caUTICA E FARMACOECONOMIA","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b9fe67ac5913452aa145cd80ec314f19","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9fe67ac5913452aa145cd80ec314f19","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jornal de Assist\u00eancia Farmac\u00eautica e Farmacoeconomia, Vol 1, Iss s. 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22563/2525-7323.2016.v1.s1.p.27","doi":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","is_oa":true,"landing_page_url":"https://doi.org/10.22563/2525-7323.2016.v1.s1.p.27","pdf_url":"https://ojs.jaff.org.br/ojs/index.php/jaff/article/download/176/233","source":{"id":"https://openalex.org/S4210196108","display_name":"Jornal de Assist\u00eancia Farmac\u00eautica e Farmacoeconomia","issn_l":"2525-7323","issn":["2525-7323","2525-5010"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JORNAL DE ASSIST\u00caNCIA FARMAC\u00caUTICA E FARMACOECONOMIA","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4244272181.pdf","grobid_xml":"https://content.openalex.org/works/W4244272181.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4238828700","https://openalex.org/W2467036329","https://openalex.org/W1554917169","https://openalex.org/W2506934489","https://openalex.org/W4392141330","https://openalex.org/W7223000107","https://openalex.org/W4322726970","https://openalex.org/W2913206931","https://openalex.org/W4242404927","https://openalex.org/W2143275625"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"A":[1,182,284,372],"osteoporose":[2,94,113,179,432],"\u00e9":[3,35,265,387],"uma":[4,120,420],"doen\u00e7a":[5],"osteoesquel\u00e9tica":[6],"sist\u00eamica":[7],"caracterizada":[8],"por":[9,215,326],"diminui\u00e7\u00e3o":[10],"da":[11,18,38,112,178,195,274,339,431],"densidade":[12],"mineral":[13],"\u00f3ssea":[14,40],"(DMO)":[15],"e":[16,41,87,105,132,143,145,228,304,337,365,397,438],"deteriora\u00e7\u00e3o":[17],"microarquitetura":[19],"do":[20,42,89,107,173,348,367,402,427],"tecido":[21,48],"\u00f3sseo.":[22,49],"Mulheres":[23],"na":[24,60,93,116,180,204,433],"p\u00f3s-menopausa":[25],"tem":[26,53],"risco":[27],"aumentado":[28],"de":[29,44,71,124,141,147,155,159,191,193,226,253,312,345,352,355,374,384,392,394],"desenvolver":[30],"a":[31,85,103,153,169,282,320,335,363,390,406],"doen\u00e7a.":[32],"O":[33,50,79,295],"pamidronato":[34,90,108,174,214,264,296,403,428],"um":[36,208,223,243,250],"inibidor":[37],"reabsor\u00e7\u00e3o":[39],"acesso":[43],"precursores":[45],"osteocl\u00e1sticos":[46],"ao":[47,269],"medicamento":[51],"n\u00e3o":[52,229,277,327,358,386,418],"indica\u00e7\u00e3o":[54,377],"em":[55,114,138,249,267,310,369,382,404,410],"bula":[56],"para":[57,68,91,101,109,151,175,271,281,331,379,423],"o":[58,69,110,176,213,263,272,302,308,332,350,380,400,425],"uso":[59,92,381,401,426],"osteoporose,":[61,275],"entretanto":[62],"foi":[63,83,149,187,290],"inclu\u00eddo":[64],"no":[65,429],"arsenal":[66],"terap\u00eautico":[67],"tratamento":[70,111,177,273,353,368,430],"pacientes":[72,227],"que":[73,166,262,301,307,349,357],"s\u00e3o":[74],"intolerantes":[75],"aos":[76],"bifosfonatos":[77],"orais.":[78],"objetivo":[80],"desse":[81],"trabalho":[82],"avaliar":[84,102,361],"efic\u00e1cia":[86,104,170,364],"seguran\u00e7a":[88,106,172,366],"p\u00f3s-menopausa.":[95,117,181,434],"M\u00e9todo:":[96],"Foi":[97,118],"realizada":[98,119,150],"revis\u00e3o":[99],"sistem\u00e1tica":[100],"mulheres":[115],"busca":[121],"nas":[122],"bases":[123,140],"dados":[125],"Medline":[126],"(via":[127,134],"PubMed),":[128],"The":[129],"Cochrane":[130],"Library":[131],"Lilacs":[133],"BVS).":[135],"Busca":[136],"complementar":[137],"peri\u00f3dicos,":[139],"teses":[142],"disserta\u00e7\u00f5es":[144],"resumos":[146],"congressos":[148],"garantir":[152],"inclus\u00e3o":[154],"todos":[156],"os":[157,231],"estudos":[158,186,210,221,239,288,323,342,395],"interesse.":[160],"Foram":[161,199],"inclu\u00eddos":[162,200,211],"ensaios":[163,202,416],"cl\u00ednicos":[164,203,417],"randomizados":[165],"avaliaram":[167],"comparativamente":[168],"ou":[171],"qualidade":[183,285,318],"metodol\u00f3gica":[184,286],"dos":[185,209,287,322],"avaliada":[188],"pela":[189],"escala":[190],"Risco":[192],"Vi\u00e9s":[194],"Colabora\u00e7\u00e3o":[196],"Cochrane.":[197],"Resultados:":[198],"cinco":[201,415],"an\u00e1lise":[205],"final.":[206],"Apenas":[207,237],"utilizou":[212],"via":[216],"injet\u00e1vel":[217],"como":[218],"interven\u00e7\u00e3o.":[219],"Os":[220,257,341,414],"acompanharam":[222],"pequeno":[224],"n\u00famero":[225],"reportaram":[230],"desfechos":[232],"finais,":[233],"mas":[234],"somente":[235],"intermedi\u00e1rios.":[236],"dois":[238],"utilizaram":[240],"comparadores":[241,407],"ativos,":[242],"deles":[244],"enfocando":[245],"apenas":[246],"rea\u00e7\u00f5es":[247],"gastrointestinais,":[248],"curto":[251],"per\u00edodo":[252],"tempo":[254,344,351],"(um":[255],"m\u00eas).":[256],"estudos,":[258],"avaliados":[259],"conjuntamente,":[260],"demonstram":[261],"eficaz,":[266],"rela\u00e7\u00e3o":[268,316,405],"placebo,":[270],"por\u00e9m":[276],"constituem":[278,419],"evid\u00eancia":[279],"s\u00f3lida":[280,422],"indica\u00e7\u00e3o.":[283],"dispon\u00edveis":[289],"considerada":[291],"muito":[292],"baixa.":[293],"Discuss\u00e3o:":[294],"se":[297,359],"mostrou":[298],"mais":[299,305],"eficaz":[300],"placebo":[303],"seguro":[306],"alendronato":[309],"termos":[311],"efeitos":[313],"gastrointestinais.":[314],"Em":[315],"\u00e0":[317],"metodol\u00f3gica,":[319],"maioria":[321],"estava":[324],"comprometida":[325],"fornecer":[328],"informa\u00e7\u00f5es":[329],"suficientes":[330],"julgamento":[333],"sobre":[334,399],"randomiza\u00e7\u00e3o":[336],"sigilo":[338],"aloca\u00e7\u00e3o.":[340],"apresentaram":[343],"acompanhamento":[346],"menor":[347],"recomendado":[354],"forma":[356],"pode":[360],"objetivamente":[362],"longo":[370],"prazo.":[371],"padroniza\u00e7\u00e3o":[373],"medicamentos":[375,385],"sem":[376],"formal":[378],"listas":[383],"indicada.":[388],"Observa-se":[389],"necessidade":[391],"realiza\u00e7\u00e3o":[393],"maiores":[396],"melhores":[398],"ativos":[408],"usados":[409],"larga":[411],"escala.":[412],"Conclus\u00f5es:":[413],"base":[421],"recomendar":[424],"Apoio":[435],"Financeiro:":[436],"Fapemig":[437],"CNPq.":[439]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2022-05-12T00:00:00"}