{"id":"https://openalex.org/W4244153167","doi":"https://doi.org/10.1126/science.256.5058.839","title":"Primary Structure and Functional Expression of the \u03b2 1 Subunit of the Rat Brain Sodium Channel","display_name":"Primary Structure and Functional Expression of the \u03b2 1 Subunit of the Rat Brain Sodium Channel","publication_year":1992,"publication_date":"1992-05-08","ids":{"openalex":"https://openalex.org/W4244153167","doi":"https://doi.org/10.1126/science.256.5058.839"},"language":"en","primary_location":{"id":"doi:10.1126/science.256.5058.839","doi":"https://doi.org/10.1126/science.256.5058.839","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.256.5058.839","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088221049","display_name":"Lori L. Isom","orcid":"https://orcid.org/0000-0002-9479-6729","observed_orcids":["https://orcid.org/0000-0002-9479-6729"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. L. Isom","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090352650","display_name":"Karen S. De Jongh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. S. De Jongh","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028644896","display_name":"D E Patton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. E. Patton","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92717"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92717","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113500712","display_name":"B. F. X. Reber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. F. X. Reber","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039320169","display_name":"James Offord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Offord","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005668168","display_name":"Harry Charbonneau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Charbonneau","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108367608","display_name":"Kenneth A. Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Walsh","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003520814","display_name":"Alan L. Goldin","orcid":"https://orcid.org/0000-0001-7159-0288","observed_orcids":["https://orcid.org/0000-0001-7159-0288"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Goldin","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92717"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92717","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078941732","display_name":"William A. Catterall","orcid":"https://orcid.org/0000-0001-5509-3580","observed_orcids":["https://orcid.org/0000-0001-5509-3580"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. A. Catterall","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8331,"has_fulltext":false,"cited_by_count":201,"citation_normalized_percentile":{"value":0.86381409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"256","issue":"5058","first_page":"839","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta1-subunit","display_name":"beta1 subunit","score":0.8320000171661377},{"id":"https://openalex.org/keywords/sodium-channel-alpha-subunit","display_name":"sodium channel alpha subunit","score":0.6269999742507935},{"id":"https://openalex.org/keywords/sodium-channel-inactivation","display_name":"sodium channel inactivation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/voltage-dependent-inactivation","display_name":"voltage-dependent inactivation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.8531845808029175},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6946984529495239},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.6129259467124939},{"id":"https://openalex.org/C204390595","wikidata":"https://www.wikidata.org/wiki/Q18031397","display_name":"SCN3A","level":5,"score":0.5207764506340027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49908995628356934},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.48139193654060364},{"id":"https://openalex.org/C83730767","wikidata":"https://www.wikidata.org/wiki/Q24778884","display_name":"G alpha subunit","level":4,"score":0.4739413559436798},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43342846632003784},{"id":"https://openalex.org/C92825506","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Protein primary structure","level":4,"score":0.41569432616233826},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40575501322746277},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4036198854446411},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3886483907699585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36831584572792053},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.351546049118042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2926209568977356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1834067404270172},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.18197321891784668},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.14110979437828064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1328444480895996},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1126/science.256.5058.839","doi":"https://doi.org/10.1126/science.256.5058.839","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.256.5058.839","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W127920408","https://openalex.org/W1548187183","https://openalex.org/W1550583938","https://openalex.org/W1560986622","https://openalex.org/W1573864704","https://openalex.org/W1605614580","https://openalex.org/W1633445354","https://openalex.org/W1653329430","https://openalex.org/W1923688770","https://openalex.org/W1932052686","https://openalex.org/W1944685607","https://openalex.org/W1970627065","https://openalex.org/W1975304761","https://openalex.org/W1986291491","https://openalex.org/W1987374673","https://openalex.org/W1994944361","https://openalex.org/W1999503127","https://openalex.org/W2004002713","https://openalex.org/W2011657784","https://openalex.org/W2012093804","https://openalex.org/W2027652595","https://openalex.org/W2031106648","https://openalex.org/W2037384321","https://openalex.org/W2042036078","https://openalex.org/W2065928015","https://openalex.org/W2074589363","https://openalex.org/W2076892293","https://openalex.org/W2087383295","https://openalex.org/W2094362927","https://openalex.org/W2100837269","https://openalex.org/W2129039245","https://openalex.org/W2133950374","https://openalex.org/W2154128645","https://openalex.org/W2163279702"],"related_works":["https://openalex.org/W1985146688","https://openalex.org/W2132146004","https://openalex.org/W2029255000","https://openalex.org/W1605614580","https://openalex.org/W2118426007","https://openalex.org/W2053789152","https://openalex.org/W2082952610","https://openalex.org/W2078508547","https://openalex.org/W2035565538","https://openalex.org/W2019268667"],"abstract_inverted_index":{"Voltage-sensitive":[0],"sodium":[1,33,111,153],"channels":[2],"are":[3,16],"responsible":[4],"for":[5,18],"the":[6,11,25,30,54,106,109,118,132,139,146,150],"initiation":[7],"and":[8,14,44,69,94,116,142],"propagation":[9],"of":[10,29,40,98,108,121,145,149],"action":[12],"potential":[13,71],"therefore":[15],"important":[17],"neuronal":[19],"excitability.":[20],"Complementary":[21],"DNA":[22],"clones":[23],"encoding":[24],"\u03b2":[26,55,99,133],"1":[27,56,100,134],"subunit":[28,57,135],"rat":[31,89,151],"brain":[32,152],"channel":[34],"were":[35],"isolated":[36],"by":[37],"a":[38,59,64,84],"combination":[39],"polymerase":[41],"chain":[42],"reaction":[43],"library":[45],"screening":[46],"techniques.":[47],"The":[48],"deduced":[49],"primary":[50],"structure":[51],"indicates":[52],"that":[53,62,131],"is":[58,136],"22,851-dalton":[60],"protein":[61],"contains":[63],"single":[65],"putative":[66],"transmembrane":[67],"domain":[68],"four":[70],"extracellular":[72],"N-linked":[73],"glycosylation":[74],"sites,":[75],"consistent":[76],"with":[77,102],"biochemical":[78],"data.":[79],"Northern":[80],"blot":[81],"analysis":[82],"reveals":[83],"1400-nucleotide":[85],"messenger":[86],"RNA":[87],"in":[88,138],"brain,":[90],"heart,":[91],"skeletal":[92],"muscle,":[93],"spinal":[95],"cord.":[96],"Coexpression":[97],"subunits":[101,104],"\u03b1":[103],"increases":[105],"size":[107],"peak":[110],"current,":[112],"accelerates":[113],"its":[114],"inactivation,":[115],"shifts":[117],"voltage":[119],"dependence":[120],"inactivation":[122],"to":[123],"more":[124],"negative":[125],"membrane":[126],"potentials.":[127],"These":[128],"results":[129],"indicate":[130],"crucial":[137],"assembly,":[140],"expression,":[141],"functional":[143],"modulation":[144],"heterotrimeric":[147],"complex":[148],"channel.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}