{"id":"https://openalex.org/W4244088307","doi":"https://doi.org/10.1210/jcem.94.7.9997","title":"A Rat Model of Epilepsy in Women: A Tool to Study Physiological Interactions Between Endocrine Systems and Seizures","display_name":"A Rat Model of Epilepsy in Women: A Tool to Study Physiological Interactions Between Endocrine Systems and Seizures","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W4244088307","doi":"https://doi.org/10.1210/jcem.94.7.9997"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.94.7.9997","doi":"https://doi.org/10.1210/jcem.94.7.9997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.94.7.9997","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013260521","display_name":"Helen E. Scharfman","orcid":"https://orcid.org/0000-0003-4006-3383","observed_orcids":["https://orcid.org/0000-0003-4006-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen E. Scharfman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076936682","display_name":"Gauri H. Malthankar\u2010Phatak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gauri H. Malthankar-Phatak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Friedman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Friedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080670980","display_name":"Patrice S. Pearce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrice Pearce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073000103","display_name":"Daniel P. McCloskey","orcid":"https://orcid.org/0000-0003-3596-8014","observed_orcids":["https://orcid.org/0000-0003-3596-8014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel P. McCloskey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080677331","display_name":"Cynthia L. Harden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia L. Harden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059343766","display_name":"Neil James MacLusky","orcid":"https://orcid.org/0000-0002-9202-0564","observed_orcids":["https://orcid.org/0000-0002-9202-0564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil J. MacLusky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.48576041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"94","issue":"7","first_page":"2671","last_page":"2671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/women-with-epilepsy","display_name":"women with epilepsy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/animal-models-of-epilepsy","display_name":"animal models of epilepsy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pilocarpine","display_name":"pilocarpine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.984000027179718},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":0.906000018119812},{"id":"https://openalex.org/keywords/estrous-cyclicity","display_name":"estrous cyclicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ovarian-hormone-secretion","display_name":"ovarian hormone secretion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7310000061988831},{"id":"https://openalex.org/keywords/reproductive-failure","display_name":"reproductive failure","score":0.4519999921321869},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2776755955","wikidata":"https://www.wikidata.org/wiki/Q409632","display_name":"Pentobarbital","level":2,"score":0.8111023306846619},{"id":"https://openalex.org/C2780077838","wikidata":"https://www.wikidata.org/wiki/Q206348","display_name":"Barbiturate","level":2,"score":0.7481368780136108},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.7033441066741943},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.695306122303009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6375794410705566},{"id":"https://openalex.org/C2778900099","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsant","level":3,"score":0.6229488849639893},{"id":"https://openalex.org/C2777204577","wikidata":"https://www.wikidata.org/wiki/Q411461","display_name":"Pilocarpine","level":3,"score":0.600287914276123},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5970511436462402},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.592374861240387},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.5833989977836609},{"id":"https://openalex.org/C2908958330","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsants","level":4,"score":0.5690099596977234},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.5406498312950134},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44679924845695496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43691694736480713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4246687591075897},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.4127941131591797},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2896614670753479},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.2520647644996643},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20589524507522583},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1210/jcem.94.7.9997","doi":"https://doi.org/10.1210/jcem.94.7.9997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.94.7.9997","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010964675","https://openalex.org/W2167624385","https://openalex.org/W2120223157","https://openalex.org/W2027221813","https://openalex.org/W2026681272","https://openalex.org/W2048170087","https://openalex.org/W7120664202","https://openalex.org/W2008928733","https://openalex.org/W7120304542","https://openalex.org/W2088494575"],"abstract_inverted_index":{"Epilepsy":[0],"in":[1,45,69,159],"women":[2,196],"is":[3],"influenced":[4],"by":[5,153],"endocrine":[6,20],"status":[7,66],"and":[8,22,99,112,131,147,180],"antiepileptic":[9],"drugs":[10],"(AEDs),":[11],"but":[12],"without":[13],"an":[14,54,170],"animal":[15,56,172],"model,":[16],"the":[17,29,95,113,117,154,160,176],"effects":[18],"of":[19,31,97,116,121,129,156,166,190],"variables":[21],"AEDs":[23],"cannot":[24],"be":[25],"easily":[26],"dissociated":[27],"from":[28],"influence":[30],"epilepsy":[32],"itself.":[33],"Animal":[34],"models":[35],"have":[36],"had":[37],"limited":[38],"utility":[39],"because":[40],"experimentally-induced":[41],"seizures":[42,179],"typically":[43],"result":[44],"reproductive":[46],"failure.":[47],"This":[48],"study":[49,168],"was":[50,62,80,90],"conducted":[51],"to":[52,64,104,134,140,174],"develop":[53],"improved":[55,136,171],"model.":[57],"The":[58,74,127,164,184],"muscarinic":[59],"convulsant":[60],"pilocarpine":[61],"used":[63],"elicit":[65],"epilepticus":[67],"(SE)":[68],"adult":[70],"female":[71],"Sprague-Dawley":[72],"rats.":[73],"selective":[75],"estrogen":[76],"receptor":[77],"modulator":[78],"raloxifene":[79,130,146,193],"administered":[81],"30":[82],"min":[83,93],"before":[84],"pilocarpine.":[85],"An":[86],"anticonvulsant":[87],"barbiturate,":[88],"pentobarbital,":[89],"injected":[91],"5\u201310":[92],"after":[94,162],"onset":[96],"SE,":[98],"at":[100],"least":[101],"once":[102],"thereafter":[103],"minimize":[105],"acute":[106],"convulsions.":[107],"Mortality,":[108],"morbidity,":[109],"estrous":[110,137],"cyclicity,":[111],"ultimate":[114],"success":[115],"procedure":[118],"(i.e.":[119],"induction":[120],"recurrent,":[122],"spontaneous":[123,157],"seizures)":[124],"were":[125],"monitored.":[126],"combination":[128],"pentobarbital":[132,148],"led":[133],"significantly":[135],"cyclicity":[138],"compared":[139],"previous":[141],"methods.":[142],"Animals":[143],"treated":[144],"with":[145,192,197],"became":[149],"epileptic,":[150],"as":[151],"defined":[152],"recurrence":[155],"convulsions":[158],"weeks":[161],"SE.":[163,198],"results":[165,185],"this":[167],"provide":[169],"model":[173],"examine":[175],"interactions":[177],"between":[178],"ovarian":[181],"hormone":[182],"secretion.":[183],"also":[186],"suggest":[187],"that":[188],"treatment":[189],"SE":[191],"may":[194],"benefit":[195]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-05-12T00:00:00"}
