{"id":"https://openalex.org/W4244028279","doi":"https://doi.org/10.1182/blood.v110.11.427.427","title":"Genetic Influence on the Systems Biology of Sickle Stroke Risk Detected by Endothelial Gene Expression.","display_name":"Genetic Influence on the Systems Biology of Sickle Stroke Risk Detected by Endothelial Gene Expression.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W4244028279","doi":"https://doi.org/10.1182/blood.v110.11.427.427"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.427.427","doi":"https://doi.org/10.1182/blood.v110.11.427.427","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.427.427","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077093566","display_name":"Robert P. Hebbel","orcid":"https://orcid.org/0000-0002-0660-7933","observed_orcids":["https://orcid.org/0000-0002-0660-7933"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Hebbel","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011825695","display_name":"Peng Wei","orcid":"https://orcid.org/0000-0002-3721-7014","observed_orcids":["https://orcid.org/0000-0002-3721-7014"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peng Wei","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017830191","display_name":"Aixiang Jiang","orcid":"https://orcid.org/0000-0002-6153-7595","observed_orcids":["https://orcid.org/0000-0002-6153-7595"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aixiang Jiang","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021731392","display_name":"Cheryl A. Hillery","orcid":"https://orcid.org/0000-0002-1252-7497","observed_orcids":["https://orcid.org/0000-0002-1252-7497"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Hillery","raw_affiliation_strings":["The Blood Research Institute, University of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Blood Research Institute, University of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Paul Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Paul Scott","raw_affiliation_strings":["The Blood Research Institute, University of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Blood Research Institute, University of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055041074","display_name":"Stephen C. Nelson","orcid":"https://orcid.org/0000-0002-2019-4741","observed_orcids":["https://orcid.org/0000-0002-2019-4741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen C. Nelson","raw_affiliation_strings":["Minneapolis Children\u2019s Hospital, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minneapolis Children\u2019s Hospital, Minneapolis, MN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049525448","display_name":"Judy Enenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judy Enenstein","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046318545","display_name":"Liming Chang Milbauer","orcid":"https://orcid.org/0000-0002-9286-699X","observed_orcids":["https://orcid.org/0000-0002-9286-699X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liming Milbauer","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018175917","display_name":"Vidya Bodempudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vidya Bodempudi","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018997928","display_name":"Wei Pan","orcid":"https://orcid.org/0000-0002-1159-0582","observed_orcids":["https://orcid.org/0000-0002-1159-0582"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Pan","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035790918","display_name":"Betsy A Hirsch","orcid":"https://orcid.org/0000-0003-0162-6905","observed_orcids":["https://orcid.org/0000-0003-0162-6905"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Betsy Hirsch","raw_affiliation_strings":["Medicine, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084435159","display_name":"James N. Topper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"James N. Topper","raw_affiliation_strings":["Frazier Healthcare, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frazier Healthcare, Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076555782","display_name":"Ruey\u2010Bing Yang","orcid":"https://orcid.org/0000-0003-3017-3714","observed_orcids":["https://orcid.org/0000-0003-3017-3714"]},"institutions":[{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ruey-Bing Yang","raw_affiliation_strings":["Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011825695","https://openalex.org/A5017830191","https://openalex.org/A5018175917","https://openalex.org/A5018997928","https://openalex.org/A5035790918","https://openalex.org/A5046318545","https://openalex.org/A5049525448","https://openalex.org/A5076555782","https://openalex.org/A5084435159"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I84653119"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"427","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelial-gene-expression","display_name":"endothelial gene expression","score":0.722000002861023},{"id":"https://openalex.org/keywords/blood-outgrowth-endothelial-cells","display_name":"blood outgrowth endothelial cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/inflammation-signaling","display_name":"inflammation signaling","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cerebral-vasculopathy","display_name":"cerebral vasculopathy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.5230000019073486},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5049999952316284},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5910000205039978},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4129999876022339},{"id":"https://openalex.org/keywords/children-with-sickle-cell-disease","display_name":"children with sickle cell disease","score":0.6480000019073486},{"id":"https://openalex.org/keywords/redox-reactions","display_name":"redox reactions","score":0.3019999861717224},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adhesion","display_name":"adhesion","score":0.7540000081062317},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.7077768445014954},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5966768860816956},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.494123250246048},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4379411041736603},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4360138475894928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4182271957397461},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3998230993747711},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38745856285095215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38081496953964233},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37088268995285034},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.339467853307724},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3304547369480133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3265857696533203},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.427.427","doi":"https://doi.org/10.1182/blood.v110.11.427.427","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.427.427","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2169481132","https://openalex.org/W7098326441","https://openalex.org/W3004492879","https://openalex.org/W7119320516","https://openalex.org/W1967592353","https://openalex.org/W2941527818","https://openalex.org/W3090177866","https://openalex.org/W7120677292","https://openalex.org/W3085812398","https://openalex.org/W2047493725"],"abstract_inverted_index":{"Abstract":[0],"Stroke":[1],"affects":[2],"\u223c10%":[3],"of":[4,24,26,105,119,159,212,239,268,275,342,346,408,415],"children":[5],"with":[6,44,58],"sickle":[7,45,409],"cell":[8,46,144,410],"anemia.":[9],"There":[10],"is":[11,22,155,386,425],"evidence":[12],"for":[13,65,132,257,292,324,392],"a":[14,99,117,141,156,284],"familial":[15],"predisposition,":[16],"and":[17,86,127,170,279,299,306,321,380],"the":[18,42,181,193,210,228,237,273,276,319,340,347,369,393,426],"strongest":[19,365],"risk":[20,414],"predictor":[21],"presence":[23],"Circle":[25],"Willis":[27],"(CoW)":[28],"disease.":[29,50,418],"We":[30,51],"hypothesize":[31],"that":[32,145,153,224,289,297,422],"inherited":[33],"differences":[34,191,313,359,399],"in":[35,215,266,356,360,400],"endothelial":[36,122,143,148,401],"biology":[37,402,424],"influence":[38],"whether":[39],"or":[40,60,74,83,111,202,374],"not":[41,308],"child":[43],"anemia":[47,411],"develops":[48],"CoW":[49,78,106,213,417],"have":[52,167,303],"studied":[53],"20":[54,349],"subjects":[55,186,217,323,350],"(age":[56],"<20yr)":[57],"HbSS":[59],"HbS\u03b2\u00b0thal.":[61],"11":[62],"are":[63,88,140,316,372],"at-risk":[64,320,394],"stroke,":[66,73,101],"defined":[67,90],"as":[68,91],"having":[69,76,92,103],"had":[70],"an":[71],"actual":[72],"by":[75,221,412],"known":[77],"disease":[79,107,214],"(TCD":[80,108],">200":[81],"cm/sec,":[82,110],"abnormal":[84],"MRA);":[85],"9":[87],"not-at-risk,":[89],"reached":[93],"age":[94],"10":[95],"(at":[96],"least)":[97],"without":[98],"clinical":[100,406],"plus":[102],"absence":[104],"<150":[109],"normal":[112],"MRA).":[113],"From":[114],"each":[115,258,263,293,310],"subject,":[116],"sample":[118],"blood":[120],"outgrowth":[121],"cells":[123],"(BOEC)":[124],"was":[125,205],"prepared":[126],"used":[128,280],"to":[129,218,233,272,287,368,376,383,388],"obtain":[130],"RNA":[131],"gene":[133,252],"expression":[134,265],"profiling":[135],"(Affymetrix":[136],"U133A":[137],"platform).":[138],"BOEC":[139,172,395],"generic":[142],"reports":[146],"constitutive":[147],"phenotype.":[149],"Preliminary":[150],"studies":[151],"established":[152],"there":[154],"safe":[157],"\u2018window\u2019":[158],"culture":[160],"passage":[161],"number":[162],"after":[163],"any":[164],"acquired":[165],"phenotypes":[166],"washed":[168],"out":[169],"before":[171],"become":[173],"genetically":[174],"unstable;":[175],"all":[176,281],"samples":[177],"were":[178],"evaluated":[179],"at":[180],"same":[182,348],"time":[183],"point.":[184],"The":[185,364],"revealed":[187],"no":[188,357],"significant":[189],"single-gene":[190],"between":[192,318],"2":[194],"groups":[195],"(by":[196],"Welch":[197],"t":[198],"test,":[199,201],"Wilcoxon":[200],"SAM).":[203],"This":[204],"expected.":[206],"Rather,":[207],"we":[208,261],"expect":[209],"genesis":[211],"different":[216],"be":[219,389],"influenced":[220],"various":[222],"polymorphisms":[223],"impact":[225,305],"similarly":[226],"on":[227,283],"several":[229],"biological":[230,259,327,361,428],"systems":[231,362],"relevant":[232],"cerebral":[234],"vasculopathy":[235],"(potentially,":[236],"biologies":[238],"redox,":[240],"hypoxia,":[241],"shear":[242],"stress,":[243],"adhesion,":[244],"coagulation,":[245],"inflammation,":[246],"angiogenesis,":[247],"vasoregulation,":[248],"apoptosis).":[249],"Using":[250],"predetermined":[251],"sets":[253],"(having":[254],"79\u2013156":[255],"members)":[256],"system,":[260],"examined":[262],"gene\u2019s":[264],"terms":[267],"fold":[269,301],"change":[270],"relative":[271],"average":[274],"control":[277],"samples,":[278],"genes":[282],"given":[285],"list":[286],"establish":[288],"system\u2019s":[290],"\u2018score\u2019":[291],"subject":[294],"(generated":[295],"such":[296],"down-":[298],"up-ward":[300],"changes":[302],"equal":[304],"do":[307],"offset":[309],"other).":[311],"Significant":[312],"(Wald":[314],"test)":[315],"noted":[317],"not-at-risk":[322],"only":[325],"1":[326],"system:":[328],"inflammation":[329,370,384,423],"signaling":[330],"(P=.0216).":[331],"Multiple":[332],"statistical":[333],"approaches":[334],"confirm":[335],"this":[336],"conclusion.":[337],"Indirectly":[338],"supporting":[339],"veracity":[341],"our":[343],"findings,":[344],"separation":[345],"into":[351],"males":[352],"vs":[353],"females":[354],"resulted":[355],"group":[358],"scores.":[363],"contributor":[366],"transcripts":[367],"score":[371],"proximate":[373],"distal":[375],"NF\u03baB":[377],"component":[378],"RelA,":[379],"RelA":[381],"response":[382],"(IL1+TNF)":[385],"seen":[387],"greatly":[390],"exaggerated":[391],"samples.":[396],"Genetically":[397],"determined":[398],"probably":[403],"help":[404],"determine":[405],"phenotype":[407],"influencing":[413],"developing":[416],"Our":[419],"data":[420],"suggest":[421],"main":[427],"system":[429],"involved.":[430]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
