{"id":"https://openalex.org/W4243976517","doi":"https://doi.org/10.1002/9780470048672.wecb258","title":"Intramembrane Proteolysis","display_name":"Intramembrane Proteolysis","publication_year":2008,"publication_date":"2008-03-10","ids":{"openalex":"https://openalex.org/W4243976517","doi":"https://doi.org/10.1002/9780470048672.wecb258"},"language":"en","primary_location":{"id":"doi:10.1002/9780470048672.wecb258","doi":"https://doi.org/10.1002/9780470048672.wecb258","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb258","pdf_url":null,"source":{"id":"https://openalex.org/S4306534805","display_name":"Wiley Encyclopedia of Chemical Biology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"},"volume":{"id":"https://openalex.org/W605885627","display_name":"Wiley Encyclopedia of Chemical Biology"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070207434","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-5721-9092","observed_orcids":["https://orcid.org/0000-0002-5721-9092"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070207434"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramembrane-proteolysis","display_name":"intramembrane proteolysis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intramembrane-proteases","display_name":"intramembrane proteases","score":0.9739999771118164},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.6740000247955322},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.8050000071525574},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.6449999809265137},{"id":"https://openalex.org/keywords/protease-substrate-identification","display_name":"protease substrate identification","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protease-structure","display_name":"protease structure","score":0.8209999799728394},{"id":"https://openalex.org/keywords/protease-regulation","display_name":"protease regulation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.9767459630966187},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.719599723815918},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5946063995361328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5668795108795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4893011748790741},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44155237078666687},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.43365564942359924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3741205334663391},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3736925721168518},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.27800023555755615},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08726024627685547}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470048672.wecb258","doi":"https://doi.org/10.1002/9780470048672.wecb258","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb258","pdf_url":null,"source":{"id":"https://openalex.org/S4306534805","display_name":"Wiley Encyclopedia of Chemical Biology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1480987708","https://openalex.org/W1483703465","https://openalex.org/W1491665105","https://openalex.org/W1495136850","https://openalex.org/W1534001036","https://openalex.org/W1544986395","https://openalex.org/W1545574570","https://openalex.org/W1560202903","https://openalex.org/W1591850964","https://openalex.org/W1626267121","https://openalex.org/W1655404681","https://openalex.org/W1660631781","https://openalex.org/W1675105744","https://openalex.org/W1925887942","https://openalex.org/W1970552333","https://openalex.org/W1970926641","https://openalex.org/W1972706019","https://openalex.org/W1981293839","https://openalex.org/W1983469573","https://openalex.org/W1986712359","https://openalex.org/W1988601980","https://openalex.org/W1988923764","https://openalex.org/W1990434926","https://openalex.org/W1993722622","https://openalex.org/W1996310770","https://openalex.org/W1998356763","https://openalex.org/W2003599613","https://openalex.org/W2004305803","https://openalex.org/W2010281538","https://openalex.org/W2013882590","https://openalex.org/W2019007505","https://openalex.org/W2022114463","https://openalex.org/W2026596383","https://openalex.org/W2028673763","https://openalex.org/W2029502542","https://openalex.org/W2030182984","https://openalex.org/W2033796514","https://openalex.org/W2034193841","https://openalex.org/W2039999119","https://openalex.org/W2048048305","https://openalex.org/W2050173314","https://openalex.org/W2057457553","https://openalex.org/W2057736065","https://openalex.org/W2057838273","https://openalex.org/W2057970714","https://openalex.org/W2062688749","https://openalex.org/W2073420511","https://openalex.org/W2074683943","https://openalex.org/W2075802971","https://openalex.org/W2075829521","https://openalex.org/W2077244062","https://openalex.org/W2077674018","https://openalex.org/W2079019962","https://openalex.org/W2079676584","https://openalex.org/W2082195162","https://openalex.org/W2087695783","https://openalex.org/W2089824266","https://openalex.org/W2092705523","https://openalex.org/W2096410114","https://openalex.org/W2097705657","https://openalex.org/W2098079636","https://openalex.org/W2098503611","https://openalex.org/W2108761645","https://openalex.org/W2113690827","https://openalex.org/W2122391469","https://openalex.org/W2124097986","https://openalex.org/W2126070767","https://openalex.org/W2127113850","https://openalex.org/W2127639686","https://openalex.org/W2130758099","https://openalex.org/W2132989968","https://openalex.org/W2134365974","https://openalex.org/W2140822113","https://openalex.org/W2149689268","https://openalex.org/W2150970420","https://openalex.org/W2152303883","https://openalex.org/W2154196079","https://openalex.org/W2154861644","https://openalex.org/W2157895955","https://openalex.org/W2158354144","https://openalex.org/W2161756980","https://openalex.org/W2162220128","https://openalex.org/W2167310720","https://openalex.org/W2169441980","https://openalex.org/W2169488167","https://openalex.org/W2171469414","https://openalex.org/W2775777157"],"related_works":["https://openalex.org/W2078528430","https://openalex.org/W1970473265","https://openalex.org/W2083955028","https://openalex.org/W2081974627","https://openalex.org/W2050780742","https://openalex.org/W2069742629","https://openalex.org/W2021775516","https://openalex.org/W7220404490","https://openalex.org/W2287325701","https://openalex.org/W3176761161"],"abstract_inverted_index":{"Abstract":[0],"Evolutionarily":[1],"conserved":[2],"membrane\u2010embedded":[3],"enzymes":[4],"somehow":[5],"use":[6,70],"water":[7],"to":[8,32,74,84,141],"hydrolyze":[9],"peptide":[10],"bonds":[11],"that":[12,49,54,66],"reside":[13,55],"within":[14,92],"the":[15,23,57,67,103,127],"lipid":[16],"bilayer.":[17],"These":[18],"proteases":[19,35,42,53,69,129],"are":[20],"stitched":[21],"into":[22],"membrane":[24],"and":[25,114,118,139],"bear":[26],"little":[27],"or":[28],"no":[29],"sequence":[30],"similarity":[31],"other":[33],"known":[34,40],"with":[36],"one":[37],"exception:":[38],"All":[39],"intramembrane":[41,68,128],"apparently":[43],"have":[44],"converged":[45],"on":[46,101],"catalytic":[47,71],"mechanisms":[48],"resemble":[50],"those":[51,75],"of":[52,62,105,108,120],"in":[56,77,82,137],"aqueous":[58],"milieu.":[59],"The":[60],"identities":[61],"these":[63,109],"residues":[64,87],"suggest":[65],"functionalities":[72],"similar":[73],"found":[76],"their":[78,112,116],"soluble":[79],"counterparts.":[80],"However,":[81],"contrast":[83],"classical":[85],"proteases,":[86,110],"essential":[88],"for":[89],"catalysis":[90],"lie":[91],"predicted":[93],"hydrophobic":[94],"transmembrane":[95],"domains.":[96],"Current":[97],"research":[98],"is":[99,124],"focused":[100],"elucidating":[102],"range":[104],"biologic":[106],"roles":[107,136],"identifying":[111],"substrates,":[113],"understanding":[115],"structure":[117],"mechanism":[119],"action.":[121],"Such":[122],"knowledge":[123],"important":[125],"because":[126],"discovered":[130],"thus":[131],"far":[132],"play":[133],"critical":[134],"regulatory":[135],"biology":[138],"contribute":[140],"human":[142],"disease.":[143]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
