{"id":"https://openalex.org/W4243951344","doi":"https://doi.org/10.1201/9781482283495-9","title":"Nitric Oxide and Its Role in Hemostasis","display_name":"Nitric Oxide and Its Role in Hemostasis","publication_year":1999,"publication_date":"1999-06-23","ids":{"openalex":"https://openalex.org/W4243951344","doi":"https://doi.org/10.1201/9781482283495-9"},"language":"en","primary_location":{"id":"doi:10.1201/9781482283495-9","doi":"https://doi.org/10.1201/9781482283495-9","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482283495-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathophysiology and Clinical Applications of Nitric Oxide","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W599707662","display_name":"Pathophysiology and Clinical Applications of Nitric Oxide"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000418827","display_name":"Elisabeth M. Battinelli","orcid":"https://orcid.org/0000-0003-1916-047X","observed_orcids":["https://orcid.org/0000-0003-1916-047X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. M. Battinelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049891784","display_name":"Mar\u00eda Rosa Trolliet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. R. Trolliet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028396638","display_name":"Joseph Loscalzo","orcid":"https://orcid.org/0000-0002-1153-8047","observed_orcids":["https://orcid.org/0000-0002-1153-8047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Loscalzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59958071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"18","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.19709999859333038,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.9769999980926514},{"id":"https://openalex.org/keywords/platelet-disaggregation","display_name":"platelet disaggregation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.7120000123977661},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8510000109672546},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bleeding-disorders","display_name":"bleeding disorders","score":0.699999988079071},{"id":"https://openalex.org/keywords/organic-nitrates","display_name":"organic nitrates","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.7030794620513916},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6936500668525696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3496812880039215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19904863834381104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781482283495-9","doi":"https://doi.org/10.1201/9781482283495-9","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781482283495-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathophysiology and Clinical Applications of Nitric Oxide","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W20078152"],"related_works":["https://openalex.org/W5327829","https://openalex.org/W178858000","https://openalex.org/W1588013356","https://openalex.org/W2478798692","https://openalex.org/W98212133","https://openalex.org/W150631554","https://openalex.org/W1919507270","https://openalex.org/W4232189762","https://openalex.org/W1480716556","https://openalex.org/W2066256832"],"abstract_inverted_index":{"Hemostasis":[0],"depends,":[1],"in":[2,13,119,156,160,186,241],"part,":[3],"on":[4],"the":[5,14,52,75,127,171,237],"ability":[6],"to":[7,64,81,109,209],"form":[8],"a":[9,116,123,225],"protective":[10],"platelet":[11,56,87,134,173,180,220,243],"plug":[12],"event":[15],"of":[16,51,106,111,126,129,143,205,213,239],"vascular":[17],"injury":[18],"and":[19,49,89,92,136,138,148,224,245,247],"thereby":[20],"prevent":[21],"excessive":[22,29],"blood":[23],"loss.":[24],"A":[25],"poorly":[26],"controlled":[27],"or":[28,38,163,256],"hemostatic":[30,43,249],"response,":[31],"however,":[32],"can":[33,85,132,139],"be":[34,176,184,216],"manifested":[35],"as":[36,196,200],"hemorrhage":[37],"thrombosis,":[39,210],"respectively.":[40],"The":[41,104,179],"primary":[42],"response":[44,181],"is":[45,68,77,122,167,222,258],"dependent":[46],"upon":[47],"platelets":[48,146],"products":[50],"endothelium":[53,76],"that":[54,60,219,251],"modulate":[55],"function.":[57],"One":[58],"mediator":[59,125],"has":[61],"been":[62],"shown":[63],"have":[65],"antiplatelet":[66],"activity":[67],"nitric":[69,165],"oxide":[70,166],"(NO).":[71],"Under":[72],"resting":[73],"conditions":[74],"stimulated":[78],"by":[79,170],"flow":[80],"produce":[82],"NO,":[83],"which":[84,121,161,198],"regulate":[86],"adhesion":[88,135],"aggregation":[90,221],"(Pohl":[91],"Busse,":[93],"1989;":[94],"Cooke":[95],"et":[96,101,152],"al.,":[97,102,153],"1991;":[98],"de":[99],"Graaf":[100],"1992).":[103],"production":[105,255],"NO":[107,131,201,206,214,240,254],"leads":[108],"activation":[110],"soluble":[112],"guanylyl":[113],"cyclase":[114],"with":[115,188],"concomitant":[117],"increase":[118],"cGMP,":[120],"principal":[124],"effects":[128],"NO.":[130],"inhibit":[133],"aggregation,":[137],"also":[140,183],"induce":[141],"disaggregation":[142],"previously":[144],"aggregated":[145],"(Radomski":[147],"Moncada,":[149],"1991a,b;":[150],"Radomski":[151],"1987a,b,c).":[154],"Thus,":[155],"different":[157],"disease":[158,190],"states":[159],"less":[162],"more":[164],"being":[168],"produced":[169],"vasculature,":[172],"function":[174,244],"may":[175,182,207,215],"adversely":[177],"altered.":[178,259],"modulated":[185],"patients":[187],"cardiovascular":[189],"who":[191],"use":[192],"organic":[193],"nitrates,":[194],"such":[195,218],"nitroglycerin,":[197],"act":[199],"donors.":[202],"While":[203],"lack":[204],"lead":[208],"an":[211],"excess":[212],"detrimental":[217],"impaired":[223],"bleeding":[226],"diathesis":[227],"results.":[228],"In":[229],"this":[230],"chapter":[231],"we":[232],"will":[233],"provide":[234],"evidence":[235],"for":[236],"importance":[238],"regulating":[242],"hemostasis,":[246],"illustrate":[248],"disorders":[250],"arise":[252],"when":[253],"bioactivity":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
