{"id":"https://openalex.org/W4243604740","doi":"https://doi.org/10.1172/jci200215537","title":"Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus","display_name":"Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus","publication_year":2002,"publication_date":"2002-08-15","ids":{"openalex":"https://openalex.org/W4243604740","doi":"https://doi.org/10.1172/jci200215537"},"language":"en","primary_location":{"id":"doi:10.1172/jci200215537","doi":"https://doi.org/10.1172/jci200215537","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci200215537","pdf_url":"http://www.jci.org/articles/view/15537/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/15537/files/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014605629","display_name":"David M. Koelle","orcid":"https://orcid.org/0000-0003-1255-9023","observed_orcids":["https://orcid.org/0000-0003-1255-9023"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Koelle","raw_affiliation_strings":["Department of Laboratory Medicine, and","Department of Medicine,","Department of Pathobiology, University of Washington, Seattle, Washington, USA","Virginia Mason Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Department of Pathobiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Virginia Mason Research Center, Seattle, Washington, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382247","display_name":"Zhi Liu","orcid":"https://orcid.org/0000-0001-9785-9150","observed_orcids":["https://orcid.org/0000-0001-9785-9150"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Liu","raw_affiliation_strings":["Department of Laboratory Medicine, and","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011749933","display_name":"Christopher M. McClurkan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher M. McClurkan","raw_affiliation_strings":["Department of Laboratory Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091739351","display_name":"Max S. Topp","orcid":"https://orcid.org/0000-0002-1267-5289","observed_orcids":["https://orcid.org/0000-0002-1267-5289"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max S. Topp","raw_affiliation_strings":["Department of Medicine,","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087281332","display_name":"Stanley R. Riddell","orcid":"https://orcid.org/0000-0002-4688-9920","observed_orcids":["https://orcid.org/0000-0002-4688-9920"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley R. Riddell","raw_affiliation_strings":["Department of Medicine,","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025998259","display_name":"Eric G. Pamer","orcid":"https://orcid.org/0000-0002-6755-9904","observed_orcids":["https://orcid.org/0000-0002-6755-9904"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric G. Pamer","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew S. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew S. Johnson","raw_affiliation_strings":["Department of Laboratory Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052928140","display_name":"Anna Wald","orcid":"https://orcid.org/0000-0003-3486-6438","observed_orcids":["https://orcid.org/0000-0003-3486-6438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Wald","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, Washington, USA","Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061167455","display_name":"Lawrence Corey","orcid":"https://orcid.org/0000-0002-2179-2436","observed_orcids":["https://orcid.org/0000-0002-2179-2436"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Corey","raw_affiliation_strings":["Department of Laboratory Medicine, and","Department of Medicine,","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014605629"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.7544,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76238188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"110","issue":"4","first_page":"537","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-lymphocyte-associated-antigen","display_name":"cutaneous lymphocyte antigen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":0.968999981880188},{"id":"https://openalex.org/keywords/t-cell-homing","display_name":"T cell homing","score":0.7649999856948853},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.7820000052452087},{"id":"https://openalex.org/keywords/central-memory-t-cells","display_name":"central memory T cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mucosal-vaccines","display_name":"mucosal vaccines","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.613696277141571},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6037123203277588},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5993734002113342},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.525363564491272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5013480186462402},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4859410524368286},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42934876680374146},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.42482790350914},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07631200551986694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06641659140586853}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1172/jci200215537","doi":"https://doi.org/10.1172/jci200215537","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci200215537","pdf_url":"http://www.jci.org/articles/view/15537/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1172/jci200215537","doi":"https://doi.org/10.1172/jci200215537","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci200215537","pdf_url":"http://www.jci.org/articles/view/15537/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5899999737739563}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000057394","display_name":null,"funder_award_id":"AI30731","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4243604740.pdf","grobid_xml":"https://content.openalex.org/works/W4243604740.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W37119766","https://openalex.org/W1537188001","https://openalex.org/W1678352491","https://openalex.org/W1751493734","https://openalex.org/W1887482810","https://openalex.org/W1937781572","https://openalex.org/W1945834141","https://openalex.org/W1970168286","https://openalex.org/W1981480494","https://openalex.org/W1982854219","https://openalex.org/W1983509015","https://openalex.org/W1985692695","https://openalex.org/W1986795858","https://openalex.org/W1988479633","https://openalex.org/W1989550920","https://openalex.org/W1994048581","https://openalex.org/W2006551110","https://openalex.org/W2006807357","https://openalex.org/W2014730581","https://openalex.org/W2015931712","https://openalex.org/W2020617877","https://openalex.org/W2024909307","https://openalex.org/W2028146032","https://openalex.org/W2028214904","https://openalex.org/W2030716595","https://openalex.org/W2035209254","https://openalex.org/W2045312784","https://openalex.org/W2047628328","https://openalex.org/W2050730390","https://openalex.org/W2053083190","https://openalex.org/W2057177567","https://openalex.org/W2063805600","https://openalex.org/W2064653285","https://openalex.org/W2067069532","https://openalex.org/W2071505061","https://openalex.org/W2072424205","https://openalex.org/W2076744423","https://openalex.org/W2079732145","https://openalex.org/W2094128254","https://openalex.org/W2102107932","https://openalex.org/W2103384599","https://openalex.org/W2105558735","https://openalex.org/W2110933237","https://openalex.org/W2112494869","https://openalex.org/W2112647046","https://openalex.org/W2113168773","https://openalex.org/W2114962227","https://openalex.org/W2119232577","https://openalex.org/W2120313114","https://openalex.org/W2121333266","https://openalex.org/W2133997960","https://openalex.org/W2136341324","https://openalex.org/W2145164692","https://openalex.org/W2147389449","https://openalex.org/W2156555210","https://openalex.org/W2159703967","https://openalex.org/W2165869380","https://openalex.org/W2319146475"],"related_works":["https://openalex.org/W4235457408","https://openalex.org/W2128361337","https://openalex.org/W1996094402","https://openalex.org/W2735853125","https://openalex.org/W4313388408","https://openalex.org/W2141040237","https://openalex.org/W1963738773","https://openalex.org/W2096629325","https://openalex.org/W1970168286","https://openalex.org/W2141145025"],"abstract_inverted_index":{"Virus-specific":[0],"CD8":[1,27,48,65,77,131,168],"+":[2,28,49,66,78,132,169],"T":[3,29,50,67,79,119,133,170],"cells":[4,51,68,80,113,120,123,134],"traffic":[5],"to":[6,9,25,32,99,103,122],"infected":[7],"tissues":[8],"promote":[10],"clearance":[11],"of":[12,59,84,129,160,162,173,183,186],"infection.We":[13],"used":[14],"herpes":[15,137],"simplex":[16],"virus":[17],"type":[18],"2":[19],"(HSV-2)":[20],"as":[21],"a":[22,104,146],"model":[23],"system":[24],"investigate":[26],"cell":[30],"trafficking":[31],"the":[33,53,82,157,184],"skin":[34,151,176],"in":[35,52,97,116,150],"humans.Using":[36],"human":[37],"leukocyte":[38],"antigen":[39,62],"(HLA)":[40],"class":[41],"I":[42],"tetramers,":[43],"we":[44],"observed":[45],"that":[46],"HSV-specific":[47,130],"peripheral":[54],"blood":[55],"expressed":[56],"high":[57],"levels":[58],"cutaneous":[60],"lymphocyte-associated":[61],"(CLA).In":[63],"contrast,":[64],"specific":[69],"for":[70,148,175],"non-skin-tropic":[71],"herpesviruses":[72],"lacked":[73],"CLA":[74,140,149],"expression.CLA-positive":[75],"HSV-2-specific":[76],"had":[81],"characteristics":[83],"central":[85],"memory":[86],"cells,":[87],"expressing":[88],"CCR7,":[89],"CD62L,":[90],"and":[91,93,108,111,177],"CD28,":[92],"they":[94],"proliferated":[95],"briskly":[96],"response":[98],"antigen.CLA":[100],"is":[101,156],"related":[102],"functional":[105],"E-selectin":[106,110],"ligand,":[107],"both":[109],"CLA-positive":[112],"were":[114],"detected":[115],"HSV-2-infected":[117],"skin.HSV-2-specific":[118],"adhered":[121],"transfected":[124],"with":[125,142,145],"E-selectin.A":[126],"higher":[127],"proportion":[128],"recovered":[135],"from":[136],"lesions":[138],"express":[139],"compared":[141],"blood,":[143],"consistent":[144],"role":[147],"homing.To":[152],"our":[153],"knowledge,":[154],"this":[155],"first":[158],"report":[159],"expression":[161],"tissue-specific":[163,188],"adhesion-associated":[164],"molecules":[165],"by":[166],"virus-specific":[167],"cells.The":[171],"evaluation":[172],"vaccines":[174],"mucosal":[178],"pathogens":[179],"should":[180],"include":[181],"study":[182],"induction":[185],"appropriate":[187],"homing":[189],"molecules.":[190]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}