{"id":"https://openalex.org/W4243537660","doi":"https://doi.org/10.3816/ccr.2009.n.003","title":"The Rationale and Development of Therapeutic Insulin-like Growth Factor Axis Inhibition for Lung and Other Cancers","display_name":"The Rationale and Development of Therapeutic Insulin-like Growth Factor Axis Inhibition for Lung and Other Cancers","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W4243537660","doi":"https://doi.org/10.3816/ccr.2009.n.003"},"language":"en","primary_location":{"id":"doi:10.3816/ccr.2009.n.003","doi":"https://doi.org/10.3816/ccr.2009.n.003","is_oa":false,"landing_page_url":"https://doi.org/10.3816/ccr.2009.n.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210168020","display_name":"Clinical Cancer Reviews","issn_l":"1946-1674","issn":["1946-1674","1946-1682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082517668","display_name":"D. Ross Camidge","orcid":"https://orcid.org/0000-0003-3430-3213","observed_orcids":["https://orcid.org/0000-0003-3430-3213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Ross Camidge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054931755","display_name":"Rafa\u0142 Dziadziuszko","orcid":"https://orcid.org/0000-0001-8080-9843","observed_orcids":["https://orcid.org/0000-0001-8080-9843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafal Dziadziuszko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071851332","display_name":"Fred R. Hirsch","orcid":"https://orcid.org/0000-0002-6885-1894","observed_orcids":["https://orcid.org/0000-0002-6885-1894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred R. Hirsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2413,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70476123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"1","first_page":"19","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5865378379821777},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5091239809989929},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5087302327156067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48357149958610535},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4767647385597229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42026659846305847},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4115105867385864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34646075963974},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34501153230667114},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07275956869125366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3816/ccr.2009.n.003","doi":"https://doi.org/10.3816/ccr.2009.n.003","is_oa":false,"landing_page_url":"https://doi.org/10.3816/ccr.2009.n.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210168020","display_name":"Clinical Cancer Reviews","issn_l":"1946-1674","issn":["1946-1674","1946-1682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W100503789","https://openalex.org/W1556680452","https://openalex.org/W1594793990","https://openalex.org/W1967269037","https://openalex.org/W1971186189","https://openalex.org/W1976468253","https://openalex.org/W1981207182","https://openalex.org/W1989891233","https://openalex.org/W1998177819","https://openalex.org/W2001296723","https://openalex.org/W2001447115","https://openalex.org/W2005631145","https://openalex.org/W2010187447","https://openalex.org/W2023084168","https://openalex.org/W2026216334","https://openalex.org/W2028311537","https://openalex.org/W2034387252","https://openalex.org/W2040104879","https://openalex.org/W2051839343","https://openalex.org/W2063530759","https://openalex.org/W2068272278","https://openalex.org/W2072201354","https://openalex.org/W2072514327","https://openalex.org/W2074111028","https://openalex.org/W2074647644","https://openalex.org/W2080703915","https://openalex.org/W2084361750","https://openalex.org/W2088906557","https://openalex.org/W2090178010","https://openalex.org/W2091874984","https://openalex.org/W2092624752","https://openalex.org/W2094503340","https://openalex.org/W2099793562","https://openalex.org/W2100189272","https://openalex.org/W2106749014","https://openalex.org/W2112474467","https://openalex.org/W2121520362","https://openalex.org/W2125652724","https://openalex.org/W2132299300","https://openalex.org/W2144105831","https://openalex.org/W2147909933","https://openalex.org/W2151444534","https://openalex.org/W2151808807","https://openalex.org/W2152772600","https://openalex.org/W2163035954","https://openalex.org/W2164118670","https://openalex.org/W2164569674","https://openalex.org/W2164817023","https://openalex.org/W2165136032","https://openalex.org/W2219193071","https://openalex.org/W2246578212","https://openalex.org/W2284071628","https://openalex.org/W2336115228","https://openalex.org/W2340451576","https://openalex.org/W2397261717","https://openalex.org/W2512096769","https://openalex.org/W2532022854","https://openalex.org/W2536191595","https://openalex.org/W2538590401","https://openalex.org/W3140002906"],"related_works":["https://openalex.org/W2118735537","https://openalex.org/W7047907884","https://openalex.org/W3140391588","https://openalex.org/W2032617792","https://openalex.org/W2421575058","https://openalex.org/W1971186189","https://openalex.org/W2077904124","https://openalex.org/W2377090943","https://openalex.org/W2418834489","https://openalex.org/W2093034620"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}